DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr18 and Ncam2

DIOPT Version :9

Sequence 1:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	286	Identity:	65/286 - (22%)
Similarity:	104/286 - (36%)	Gaps:	102/286 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 EAVLNCRVGMLKDKTVMWVRRTAEKVSLLTVGNVTYSGDPRIRVKFQYPNNWRLL-INPTQTEDA 304
            :|.:.|||.......|.|:....|         ||...|.|..|...  ||.::| ||.:   |.
Mouse   131 DAEVVCRVSSSPAPAVSWLYHNEE---------VTTIPDNRFAVLAN--NNLQILNINKS---DE 181

  Fly   305 GVYMCQ----------------VSTHPPRVF----TTNLTV---------------LEPPL---- 330
            |:|.|:                :...||.:.    :.|.|.               .:|.:
Mouse   182 GIYRCEGRVEARGEIDFRDIIVIVNVPPAIMMPQKSFNATAERGEEMTLTCKASGSPDPTISWFR 246

  Fly   331 --RIIDEHERDVGDRYYKSGSTVDLQCQISRSFFQKERQT-ILKSTDSAND-------------A 379
              ::|:|:|     :|...||..:|..   |:...|:..: :.|:|:.|.:             .
Mouse   247 NGKLIEENE-----KYILKGSNTELTV---RNIINKDGGSYVCKATNKAGEDQKQAFLQVFVQPH 303

  Fly   380 VQKLINETTSELNLIGNVNQTQHKFSGQDLEKYFTKFITWAK----------DEEPLQGMTNRRL 434
            :.:|.||||||...:..|.:.:    |:.:.:     |||.:          |:.|     :.|:
Mouse   304 ILQLKNETTSENGHVTLVCEAE----GEPVPE-----ITWKRAIDGVMFSEGDKSP-----DGRI 354

  Fly   435 SVSDVWLTSRISIGDAKLSDSGNYSC 460
            .|......|.:.|.|.||||||.|.|
Mouse   355 EVKGQHGRSSLHIRDVKLSDSGRYDC 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	24/103 (23%)
		Ig	<258..326	CDD:299845	20/103 (19%)
		IGc2	<417..461	CDD:197706	18/54 (33%)
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274
		I-set	22..111	CDD:254352
		I-set	117..193	CDD:254352	21/75 (28%)
		IGc2	128..189	CDD:197706	21/71 (30%)
		Ig	208..301	CDD:299845	17/100 (17%)
		I-set	215..298	CDD:254352	15/90 (17%)
		Ig	300..397	CDD:299845	27/95 (28%)
		IG_like	308..395	CDD:214653	26/87 (30%)
		IG_like	413..491	CDD:214653
		IGc2	414..482	CDD:197706
		FN3	496..588	CDD:238020
		fn3	594..678	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900