DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr18 and lrit3b

DIOPT Version :9

Sequence 1:	NP_573102.1	Gene:	dpr18 / 32572	FlyBaseID:	FBgn0030723	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_009305418.1	Gene:	lrit3b / 100144406	ZFINID:	ZDB-GENE-070424-130	Length:	487	Species:	Danio rerio

Alignment Length:	280	Identity:	58/280 - (20%)
Similarity:	91/280 - (32%)	Gaps:	112/280 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 NLVSAVHLFTEA----------------VLNCRVGMLKDKTVMWVRRTAEKVSLLTVGNVTYSGD 279
            |.::|:.||:::                |.:||:..|.|     :.|..|. ||:.:.......:
Zfish   201 NDLTALWLFSDSNQTQRSFVLGLQDNPWVCDCRLSTLLD-----ISRGPES-SLVLLDRFLTCSE 259

  Fly   280 PRIRVKFQYPNNWRLLINPTQTEDAGVYMCQVS---THPPRVFT--TNLTVLEPPLRIIDEHERD 339
            |                    .:.|||....|.   ...|.|.|  |.:|.|
Zfish   260 P--------------------LDLAGVPFQSVELSRCRRPYVVTSATKITAL------------- 291

  Fly   340 VGDRYYKSGSTVDLQCQISRSFFQKERQTILKSTDSANDAVQKLINETTSELNLI--GNVNQTQH 402
                   .||||.|:|:               :|.....|:..:   .:::.||.  |...|||
Zfish   292 -------LGSTVLLRCE---------------ATGHPTPALMWI---KSAKRNLYNQGCCKQTQ- 330

  Fly   403 KFSGQDLEKYFTKFITWAKDEEPLQGMTNRRLSVSDVWLTSRISIGDAKLSDSGNYSCSLGRLFT 467
              |..|.|::..|...:.: |.|..|:.         |  |.:|:.....||:|.|.|
Zfish   331 --SSLDTERFPKKLFGYVQ-ESPRVGVR---------W--SVVSLNGISYSDAGEYRC------- 374

  Fly   468 VIVQVQVLTGELPAAVQHNI 487
               :.|.:.|...|.|..|:
Zfish   375 ---RAQNMAGISEAVVSLNV 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr18	NP_573102.1	IG_like	242..325	CDD:214653	18/103 (17%)
		Ig	<258..326	CDD:299845	14/72 (19%)
		IGc2	<417..461	CDD:197706	10/43 (23%)
lrit3b	XP_009305418.1	LRRNT	51..92	CDD:214470
		leucine-rich repeat	69..89	CDD:275380
		LRR_8	112..172	CDD:290566
		leucine-rich repeat	114..137	CDD:275378
		leucine-rich repeat	138..161	CDD:275378
		LRR_8	160..214	CDD:290566	4/12 (33%)
		LRR_4	160..201	CDD:289563	58/280 (21%)
		leucine-rich repeat	162..185	CDD:275378
		leucine-rich repeat	186..199	CDD:275378
		leucine-rich repeat	215..230	CDD:275378	0/14 (0%)
		Ig	278..391	CDD:299845	39/175 (22%)
		I-set	279..391	CDD:254352	39/174 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900