Protein Alignment vap and RASAL2

DIOPT Version :9

• Sequence 1: NP_001285314.1
• Gene: vap / 32569
• FlyBaseID: FBgn0003969
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: XP_016858338.1
• Gene: RASAL2 / 9462
• HGNCID: 9874
• Length: 1419
• Species: Homo sapiens
• Alignment Length: 594
• Identity: 145/594 - (24%)
• Similarity: 252/594 - (42%)
• Gaps: 113/594 - (19%)

  Fly   376 KKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGS-------------------ETQLCF---YDN 418
            |::||.........|.|:.|.::.......:|.|                   .|..|.   ...
Human   322 KRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGE 386

  Fly   419 PKKTKPKGLIDLSCAYLYQCHDSLWERPYCFQIVERALPCLATVTYL-------CAPSQESYVEW 476
            |...||             .|.|:..:.:||:           ||||       |..:.|. .:|
Human   387 PVSVKP-------------LHSSILGQDFCFE-----------VTYLSGSKCFSCNSASER-DKW 426

  Fly   477 INSLKAQCDSQLSRAQKKVSRLRELRCLNLHVLEAHRL-PFKLVPHPYCSISLNQVKVGKTRVKI 540
            :.:|:..........::..:.||      |.::||..| |.|..   :|.:.|:.....:|..|.
Human   427 MENLRRTVQPNKDNCRRAENVLR------LWIIEAKDLAPKKKY---FCELCLDDTLFARTTSKT 482

  Fly   541 APEPV-WEEEFVLDDVPPDVVSLTITLI----SRGKRGKDSEVAELTIDLSSLKNGQETEGWYQL 600
            ..:.: |.|.|....:|| :.|:|:.:.    .:.|:.|::.|..:.|..:|:...|..|.||.:
Human   483 KADNIFWGEHFEFFSLPP-LHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPV 546

  Fly   601 TGMTP-MGEWG--SLRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKALAELCH-NDRVPLATA 661
            :..|| .|:.|  |:|::.|:....|:|.|:|....:.:..:.......|..:.. .::..||.|
Human   547 STPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACA 611

  Fly   662 LLRVFRQEKRETELIRMLCQAEVTRENETTTL-FRGASLATTLMDLYMRTECSGFLQSAVSETVQ 725
            |:.:.:...|..:.:..|..:||.|..|...| ||..::||..::.|::.....:|..|:.|.::
Human   612 LVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIK 676

  Fly   726 RILESKQSAELNPTKMDVNDDACTNAEF------LLQILDLVTQSIFTSPDACPRNVRFICSCLQ 784
            .:.||.::.|::|:|       |:::|.      |....:|....|..|....||.:
Human   677 ALYESDENCEVDPSK-------CSSSELIDHQSNLKMCCELAFCKIINSYCVFPREL-------- 726

  Fly   785 KAVMAKWPTERL------VRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCL 843
            |.|.|.|..:.|      :..|::|..:|||.||||:::|..|.|:.|.|....:|:|.::||.:
Human   727 KEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVI 791

  Fly   844 QNLANLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGM--FVEQSTNLNSQDTG 906
            |||||..:||.||:||..:|.|:......|..||.::|:.:..:...|.  ::         |.|
Human   792 QNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYI---------DLG 847

  Fly   907 RELATLHHI 915
            |||:.||.:
Human   848 RELSVLHSL 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722
		SH2_Cterm_RasGAP	252..326	CDD:198217
		PH_RASA1	379..484	CDD:270080	24/133 (18%)
		C2_Ras_p21A1	499..622	CDD:176045	34/131 (26%)
		RasGAP	620..954	CDD:413381	85/312 (27%)
RASAL2	XP_016858338.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820