DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vap and SYNGAP1

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_006763.2	Gene:	SYNGAP1 / 8831	HGNCID:	11497	Length:	1343	Species:	Homo sapiens

Alignment Length:	658	Identity:	164/658 - (24%)
Similarity:	273/658 - (41%)	Gaps:	145/658 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 GHSLNHPVVNGIQPEFNQQYVVEKAAEKIYATLRECRDQIGLKKIKGIKHHGHLNKKSDKTTKWK 398
            |.|....|..|      :||.:|.|..   |..|..:..:. :::|..........|.|:|:.::
Human   103 GRSRRKSVPGG------KQYSMEGAPA---APFRPSQGFLS-RRLKSSIKRTKSQPKLDRTSSFR 157

  Fly   399 QL---YFALINDGSETQLCFYDNPKKTKPKGLIDLSCA------------YLYQCHDSLWERPYC 448
            |:   :.:..:|.:.....|.::...   :.|:..|.|            .:...|.|:..:.:|
Human   158 QILPRFRSADHDRARLMQSFKESHSH---ESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFC 219

  Fly   449 FQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQK--KVSRLRELRCLNLHVLEA 511
            |::...:    .|..:.|..:.|. .:||.:|:        ||.|  |.:..|....|.|.::||
Human   220 FEVTTSS----GTKCFACRSAAER-DKWIENLQ--------RAVKPNKDNSRRVDNVLKLWIIEA 271

  Fly   512 HRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPV------WEEEFVLDDVPPDVVSLTITLI--S 568
            ..||.|  ...||.:.|:.:...:|..|  |...      |.|.|..:::|. |.:|.:.|.  |
Human   272 RELPPK--KRYYCELCLDDMLYARTTSK--PRSASGDTVFWGEHFEFNNLPA-VRALRLHLYRDS 331

  Fly   569 RGKRGKDSE--VAELTIDLSSLKNGQETEGWYQLT------GMTPMGEWG--------------- 610
            ..||.||..  |..:|:.:::|.....||.||.:|      |...||..|
Human   332 DKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGG 396

  Fly   611 --SLRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKALAELCH--------NDRVPLATALLRV 665
              ::||:.||....|:|.|.|....:       |.......||.        ..:..:|:||:.:
Human   397 CPAVRLKARYQTMSILPMELYKEFAE-------YVTNHYRMLCAVLEPALNVKGKEEVASALVHI 454

  Fly   666 FRQEKRETELIRMLCQAEVTRENETTTL-FRGASLATTLMDLYMRTECSGFLQSAVSETVQRILE 729
            .:...:..:.:..:..:||.|..|...| ||..:|||..::.|||.....:|:.|:.|.::.:.|
Human   455 LQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYE 519

  Fly   730 SKQSAELNPTKMDVNDDACTNAEF------LLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVM 788
            |:::.|::|.|       ||.:..      |....:|....:..|....||.:        |.|.
Human   520 SEENCEVDPIK-------CTASSLAEHQANLRMCCELALCKVVNSHCVFPREL--------KEVF 569

  Fly   789 AKWPTERL---------VRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQ 844
            |.|   ||         :..|::|..:|||.||||:::|..|||:.|.|....:|:|.::||.:|
Human   570 ASW---RLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQ 631

  Fly   845 NLANLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNS----QDT 905
            ||||..:|..||.::..:|.|:......|..||.::|:           ::..||.:|    .|.
Human   632 NLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISN-----------LDTLTNSSSFEGYIDL 685

  Fly   906 GRELATLH 913
            ||||:|||
Human   686 GRELSTLH 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722
		SH2_Cterm_RasGAP	252..326	CDD:198217
		PH_RASA1	379..484	CDD:270080	20/119 (17%)
		C2_Ras_p21A1	499..622	CDD:176045	42/155 (27%)
		RasGAP	620..954	CDD:413381	88/322 (27%)
SYNGAP1	NP_006763.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	92..129		10/34 (29%)
		PH_SynGAP	122..313	CDD:270178	42/214 (20%)
		C2_SynGAP_like	252..414	CDD:175980	44/166 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..394		4/20 (20%)
		RasGAP_DAB2IP	405..728	CDD:213338	90/325 (28%)
		DUF3498	718..1310	CDD:403279
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..753
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..805
		SH3-binding. /evidence=ECO:0000255	785..815
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	933..1017
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1033..1154
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920