Protein Alignment vap and IRA2

DIOPT Version :10

• Sequence 1: NP_523361.1
• Gene: vap / 32569
• FlyBaseID: FBgn0003969
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: NP_014560.1
• Gene: IRA2 / 854073
• SGDID: S000005441
• Length: 3079
• Species: Saccharomyces cerevisiae
• Alignment Length: 865
• Identity: 162/865 - (18%)
• Similarity: 313/865 - (36%)
• Gaps: 230/865 - (26%)

  Fly    92 YSAESRLRGSSKLG--SYL---------VRESDRKPGSYVLSYYGRTGINHFR-ITAVCGDFYIG 144
            ||::.::..:.|:.  .||         :.::|            :|.:::.. :.|:|.|
Yeast  1212 YSSQQKIEKTLKIAYTEYLSAINFHERNIDDAD------------KTWVHNIEFVEAMCHD---- 1260

  Fly   145 GRQFISLSDLVGYYTSCSDLLKRER----LAIPVAPPEPVNDKKRVVAILPYTKM-PETDELSFQ 204
                       .|.||.|...:|..    |.....|...:.|..|::    |.|. ..|...|.:
Yeast  1261 -----------NYTTSGSIAFQRRTRNNILRFATIPNAILLDSMRMI----YKKWHTYTHSKSLE 1310

  Fly   205 KGDIFFVHNDMG-----DGWLWVTAHRTGEQGMIFRELVDDLDVSIDP--NTVFPWF-HPN-CTK 260
            |.:.....|..|     .|.|::......|......:.|.:|..:||.  :....|. :|: .|:
Yeast  1311 KQERNDFRNFAGILASLSGILFINKKILQEMYPYLLDTVSELKKNIDSFISKQCQWLNYPDLLTR 1375

  Fly   261 NEAVDML-VKAGPGSF------------------LVRPSDNSPGDYSLFFHINNQIQRF--RIEK 304
            ..:.|:| |:..|.||                  |..|.:.|  .|.|...|...::..  |.:.
Yeast  1376 ENSRDILSVELHPLSFNLLFNNLRLKLKELACSDLSIPENES--SYVLLEQIIKMLRTILGRDDD 1438

  Fly   305 KGVRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPVVNGIQPEFNQQYVVEKA---AEKIYATL 366
            ..|..|......:.:|.:.:..:|                 .|.:..:|:  ||   ..|:::.|
Yeast  1439 NYVMMLFSTEIVDLIDLLTDEIKK-----------------IPAYCPKYL--KAIIQMTKMFSAL 1484

  Fly   367 RECRDQIGLKKIKGIKHHGHL-NKKSDKTTKWKQLYFALINDGSETQLCFYDNPKKTKPKGLIDL 430
            :  ..::.|    |:|:|.|: ||...:.|.|.|:..|...|       |.:..|..|...|:..
Yeast  1485 Q--HSEVNL----GVKNHFHVKNKWLRQITDWFQVSIAREYD-------FENLSKPLKEMDLVKR 1536

  Fly   431 SCAYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQKKV 495
            ....||               ::.|:.....:.||   ::.:::|   ...|..|.:|||::..:
Yeast  1537 DMDILY---------------IDTAIEASTAIAYL---TRHTFLE---IPPAASDPELSRSRSVI 1580

  Fly   496 SRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPVW--EEEFVLDDVPPD 558
            ...                        |.:|.:..::....|...   ||:  .:..||:|
Yeast  1581 FGF------------------------YFNILMKGLEKSSDRDNY---PVFLRHKMSVLND---- 1614

  Fly   559 VVSLTITLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEWGSLRLRMRYLDDLI 623
                                 .:.:.|::|.| ...:...|.|  .|||..|:..:|..:|:..|
Yeast  1615 ---------------------NVILSLTNLSN-TNVDASLQFT--LPMGYSGNRNIRNAFLEVFI 1655

  Fly   624 MPCEEYSPLQQLLLESELYAVKAL-----------------AELC-HNDRVPLATALLRVFRQEK 670
            .....|   :....:::|..::|.                 |.:| .:|....|..|:..|....
Yeast  1656 NIVTNY---RTYTAKTDLGKLEAADKFLRYTIEHPQLSSFGAAVCPASDIDAYAAGLINAFETRN 1717

  Fly   671 RETELIRMLCQAEVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAE 735
            ....::..|.:.|:.:.:..|.:.|..|.||..:.:..|::.:.:|...:...:::|::::...|
Yeast  1718 ATHIVVAQLIKNEIEKSSRPTDILRRNSCATRSLSMLARSKGNEYLIRTLQPLLKKIIQNRDFFE 1782

  Fly   736 LNPTKMDVNDDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVRTR 800
            :...|.: :.||....|..::.::.:.:||..|....|..:.:||..:.|....|:|...::
Yeast  1783 IEKLKPE-DSDAERQIELFVKYMNELLESISNSVSYFPPPLFYICQNIYKVACEKFPDHAII--- 1843

  Fly   801 VVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQYME----- 860
            ....|:|||..||||::|....:: :...::..|:.:.:||.:||:||     |.|.:..
Yeast  1844 AAGSFVFLRFFCPALVSPDSENII-DISHLSEKRTFISLAKVIQNIAN-----GSENFSRWPALC 1902

  Fly   861 VVNPFILKNKERMIVFLDQL 880
            ....|:.:..:|:..||.:|
Yeast  1903 SQKDFLKECSDRIFRFLAEL 1922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_523361.1	SH2_Nterm_RasGAP	64..166	CDD:198216	14/85 (16%)
		SH3_RasGAP	183..241	CDD:212722	12/63 (19%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	19/96 (20%)
		PH_RASA1	379..484	CDD:270080	22/105 (21%)
		C2_Ras_p21A1	499..622	CDD:176045	19/124 (15%)
		RasGAP	620..954	CDD:470620	57/284 (20%)
IRA2	NP_014560.1	RasGAP_Neurofibromin_like	1672..1990	CDD:213341	54/261 (21%)