Protein Alignment vap and IRA1

DIOPT Version :10

• Sequence 1: NP_523361.1
• Gene: vap / 32569
• FlyBaseID: FBgn0003969
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: NP_009698.3
• Gene: IRA1 / 852437
• SGDID: S000000344
• Length: 3092
• Species: Saccharomyces cerevisiae
• Alignment Length: 939
• Identity: 188/939 - (20%)
• Similarity: 326/939 - (34%)
• Gaps: 254/939 - (27%)

  Fly    85 YHGRLDRYSAESRLRGSSKLGSY-------LVRESDRKPGSYVLSYYGRTGINHFRITAVCGDFY 142
            |.|.||:||.            |       :.:::....||..|....|..|    :|      |
Yeast  1229 YVGALDQYSI------------YNIDFIDAMAQDNFTASGSVALQRRLRNNI----LT------Y 1271

  Fly   143 IGGRQFISLS--DLV---GYYTSCSDLLKRERLAIPVAPPEPVNDKKRVVAILP-----YTKMPE 197
            |.|...|.|.  |::   .:|.|||..:.:|.|.          |.:.:..||.     .:.|.|
Yeast  1272 IKGSDSILLDSMDVIYKKWFYFSCSKSVTQEELV----------DFRSLAGILASMSGILSDMQE 1326

  Fly   198 T-----------DELSFQ-KGDIFFVHNDM--------------GDGWLWVTAHRTGEQGMIFRE 236
            .           |.|||: :...:.||..:              ...||       ....::.||
Yeast  1327 LEKSKSAPDNEGDSLSFESRNPAYEVHKSLKLELTKKMNFFISKQCQWL-------NNPNLLTRE 1384

  Fly   237 LVDD-LDVSIDP---NTVFPWFHPNCTKNEAVDMLVKAGPGSFLVRPSDNSPGDYSLFFHINNQI 297
            ...| |.:.:.|   |.:|........:..::|:.......||::..        .:...|...:
Yeast  1385 NSRDILSIELHPLSFNLLFNNLGLKIDELMSIDLSKSHEDSSFVLLE--------QIIIIIRTIL 1441

  Fly   298 QRFRIEKKGVRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPVVNGIQPEFNQQYVVEKAAEKI 362
            :|...||     :|...:.:.||||      ::::|       :|..|..:.::.|.......|:
Yeast  1442 KRDDDEK-----IMLLFSTDLLDAV------DKLIE-------IVEKISIKSSKYYKGIIQMSKM 1488

  Fly   363 YATLRECRDQIGLKKIKGIKHHGHLNKKSDKTTKWKQL---YFAL-INDGSETQLCFYDNPKKTK 423
            :......      :|..||.:|.||.      .||.:|   :|.| ||..       ||....::
Yeast  1489 FRAFEHS------EKNLGISNHFHLK------NKWLKLVIGWFKLSINKD-------YDFENLSR 1534

  Fly   424 PKGLIDLSCAYLYQCHDSLWERPYCFQIVERALPCLATVTYLC------APSQESYVEWINSLKA 482
            |...:||.            :|...|..::.::.....:.||.      .|...|..:|..|...
Yeast  1535 PLREMDLQ------------KRDEDFLYIDTSIESAKALAYLTHNVPLEIPPSSSKEDWNRSSTV 1587

  Fly   483 QCDSQLSRAQKKVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVG-KTRVKIAPEPVW 546
            ...:..:...|.:.:                           |..|||..|. :.::.|..|.|.
Yeast  1588 SFGNHFTILLKGLEK---------------------------SADLNQFPVSLRHKISILNENVI 1625

  Fly   547 EEEFVLDDVPPDVVSLTITLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEWGS 611
            .....|.:...: |||..||.......||..:|.|.:.:..:.|.......:::.
Yeast  1626 IALTNLSNANVN-VSLKFTLPMGYSPNKDIRIAFLRVFIDIVTNYPVNPEKHEMD---------- 1679

  Fly   612 LRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKALAELCHNDRVPL-ATALLRVFRQEKRETEL 675
               :|..:||.         |:.::....|....:||  |....|.| |...|..|........|
Yeast  1680 ---KMLAIDDF---------LKYIIKNPILAFFGSLA--CSPADVDLYAGGFLNAFDTRNASHIL 1730

  Fly   676 IRMLCQAEVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTK 740
            :..|.:.|:.|...:..:.|..|.||..:.||.|:..:.:|...:...:|.|:::|:|.|::..|
Yeast  1731 VTELLKQEIKRAARSDDILRRNSCATRALSLYTRSRGNKYLIKTLRPVLQGIVDNKESFEIDKMK 1795

  Fly   741 MDVNDDACTNAE--------FLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLV 797
                 ....|:|        ::.:::|.:|.||    |..|..:..||..:..|....:|....:
Yeast  1796 -----PGSENSEKMLDLFEKYMTRLIDAITSSI----DDFPIELVDICKTIYNAASVNFPEYAYI 1851

  Fly   798 RTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRS-LVMVAKCLQNLANLIEFGGKEQYMEV 861
               .|..|:|||.:.|||::|....::..|  .|..|. .:.:||.:|:|||..|...|:..:..
Yeast  1852 ---AVGSFVFLRFIGPALVSPDSENIIIVT--HAHDRKPFITLAKVIQSLANGRENIFKKDILVS 1911

  Fly   862 VNPFILKNKERMIVFLDQLSSV----------NDPNQPLGM---FVEQSTNLNSQDTGRELATLH 913
            ...|:....:::..||.:|..:          .||. |:..   |:.:...||.....:|:
Yeast  1912 KEEFLKTCSDKIFNFLSELCKIPTNNFTVNVREDPT-PISFDYSFLHKFFYLNEFTIRKEI---- 1971

  Fly   914 HICVSHSQELHELSNILSIKKLVTVTDML 942
               ::.|:...|.|   .:|..|.:.|.:
Yeast  1972 ---INESKLPGEFS---FLKNTVMLNDKI 1994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_523361.1	SH2_Nterm_RasGAP	64..166	CDD:198216	23/92 (25%)
		SH3_RasGAP	183..241	CDD:212722	15/89 (17%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	12/73 (16%)
		PH_RASA1	379..484	CDD:270080	25/114 (22%)
		C2_Ras_p21A1	499..622	CDD:176045	21/123 (17%)
		RasGAP	620..954	CDD:470620	79/346 (23%)
IRA1	NP_009698.3	RasGAP_Neurofibromin_like	1679..1995	CDD:213341	80/365 (22%)