DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vap and rasal3

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_005165804.1	Gene:	rasal3 / 798492	ZFINID:	ZDB-GENE-101130-3	Length:	1124	Species:	Danio rerio

Alignment Length:	803	Identity:	186/803 - (23%)
Similarity:	306/803 - (38%)	Gaps:	199/803 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 VTAHRTGEQGMIFRELVDDLDVSIDPNTVFP-WFHPNCTKNEAVDMLVKAGPGSFLVRPSDNSPG 285
            ||.|...|...:   |.|.:.:|..|....| |...||...:          |..|: |.:..|
Zfish   175 VTEHEKCEPDYV---LQDPVRLSWAPPQEVPVWDISNCFLQD----------GQILI-PREEEP- 224

  Fly   286 DYSLFFHINNQIQRFRIEKKGVRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPVVNGIQPEFN 350
                ...:.|                  |...||.:|             ||.:  ::|...|.|
Zfish   225 ----MMTVRN------------------RASSCLFSV-------------SLQN--ISGSHAELN 252

  Fly   351 QQYVVEKAAEKIYATLRECRDQIGLKKIKGIKHHGHLNKK---SDKTTKWKQLYFALIN----DG 408
            ...||..:..|:       :.|.|     |:|  |.:.::   .||.....||..|.::    .|
Zfish   253 PDPVVPSSGTKL-------KGQDG-----GVK--GLIKRRLQGDDKRKSSTQLNTAGLSVAARYG 303

  Fly   409 SETQLCFYDNPKKTKPKGLIDLSC---AYLYQCHDSLWERPYCFQIV-ERALPCLATVTYLCAPS 469
            |:..|....:..|:     ::||.   ..:...|.|:....||||:: .....|..     |..:
Zfish   304 SKESLSIPVSAAKS-----LNLSADQTTVIRPVHSSILGEKYCFQVINSENNHCFG-----CTSA 358

  Fly   470 QESYVEWINSLKAQCDSQLSRAQKKVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVG 534
            .|. ..||..|:..........::..:.|    ||.::  ||..||.|  ...||.:.|:.....
Zfish   359 AER-DRWIEDLRRTAHPNKDNCERTENSL----CLWIN--EAKDLPPK--KRYYCEVHLDGTLFA 414

  Fly   535 KTRVKIAPEPV--------------------------WEEEFVLDDVPPDVVSLTITLISRGKRG 573
            :|..:...:.|                          |.|.|.||::|| |..:|:.|.    :|
Zfish   415 RTSSRAVGKSVQRSSQAVDGGSGAFGSGGTSGGCQLFWGEFFELDNLPP-VTQITLHLF----KG 474

  Fly   574 KDSE-------------VAELTIDLSSLKNGQETEGWYQLTGMTPMGE---------WGSLRLRM 616
            :|.:             :..:.:.|:.:|.....|.||::....|.|.         ..|:|::.
Zfish   475 EDPKKKRHSRDDATLHPLGSVALPLADIKGRAYQEKWYRIVAYKPPGTSTAKDSVELQASIRVKA 539

  Fly   617 RYLDDLIMPCEEYSPLQQLLLESELYAVKALAELCH-NDRVPLATALLRVFRQEKRETELIRMLC 680
            ::.:..|:|.|.|....:.:..:.:....:|..|.: .::..||.||:.|.:...:..|.:..|.
Zfish   540 KFKNLKILPIERYKEFAEYVTVNYVDMCSSLEPLLNVREKEELAGALVHVLQSIGKAKEFLIDLG 604

  Fly   681 QAEVTR--ENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDV 743
            .|||.|  ||| ..:||..:|||..:|.||:.....:|...:.:.:.|:....::.|::|.|...
Zfish   605 SAEVQRLGENE-ALIFRENTLATKAIDEYMKLVGQKYLIDTLGDFIARLYNGGENCEVDPLKCSP 668

  Fly   744 NDDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPT------ERLVRTRVV 802
            : |...|...|.:..:.|.:.|....::.|..:..|.|        .|.:      ::.:..|::
Zfish   669 S-DLPINQRHLKETCEDVVKRITDMQESFPAELNDIFS--------SWVSDCEDRGQQDIGQRLI 724

  Fly   803 SGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQYMEVVNPFIL 867
            |..:|||.||||:|:|..|||....|.....|:|.:.||.:|||||...||.||:||..:|.|:.
Zfish   725 SASLFLRFLCPAILSPSLFGLTQPYPETNTLRTLTLTAKVIQNLANFTLFGEKEEYMFFMNDFLT 789

  Fly   868 KNKERMIVFLDQLSSVNDPNQPLGM-----FVEQSTNLNSQDTGRELATLHHICV--------SH 919
            ::.|.|   .|.|..|::|...:.|     :|         |....||.||::.|        ..
Zfish   790 QHWEPM---RDFLQKVSNPESEITMSRFDGYV---------DLPLRLAVLHNLLVDIISVMKQDQ 842

  Fly   920 SQELHELSNILSIKKLVTVTDML 942
            ...||.|..||:     .:|:.|
Zfish   843 IDNLHPLPRILN-----QITEFL 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722	6/18 (33%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	13/74 (18%)
		PH_RASA1	379..484	CDD:270080	26/115 (23%)
		C2_Ras_p21A1	499..622	CDD:176045	33/170 (19%)
		RasGAP	620..954	CDD:413381	95/345 (28%)
rasal3	XP_005165804.1	PH_RasSynGAP-like	256..382	CDD:270082	31/150 (21%)
		C2_SynGAP_like	374..549	CDD:175980	35/187 (19%)
		RasGAP	532..859	CDD:214617	96/353 (27%)
		RasGAP_DAB2IP	540..862	CDD:213338	95/348 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820