DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vap and Dab2ip

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001107596.1	Gene:	Dab2ip / 69601	MGIID:	1916851	Length:	1189	Species:	Mus musculus

Alignment Length:	517	Identity:	140/517 - (27%)
Similarity:	239/517 - (46%)	Gaps:	69/517 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 IDLSC---AYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLS 489
            :|||.   ..:...|.|:..:.|||::...:    .:..:.|..:.|. .:|:.:|:     :..
Mouse   147 LDLSMEEEVIIKPVHSSILGQDYCFEVTTSS----GSKCFSCRSAAER-DKWMENLR-----RAV 201

  Fly   490 RAQKKVSRLRELRCLNLHVLEAHRLPFKLVPHPY-CSISLNQVKVGKTRVKIAPEPV-WEEEFVL 552
            ...|..|| |....|.|.|:||..||.|   ..| |.:.|:.|...:|..|:..:.| |.|.|..
Mouse   202 HPNKDNSR-RVEHILKLWVIEAKDLPAK---KKYLCELCLDDVLYARTTSKLKTDNVFWGEHFEF 262

  Fly   553 DDVPPDVVSLTITLI----SRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEWG--- 610
            .::|| :.::|:.|.    .:.|:.::|.:..:::..:|:...|..|.||.:....|.|..|
Mouse   263 HNLPP-LRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGP 326

  Fly   611 SLRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKALAE-LCHNDRVPLATALLRVFRQEKRETE 674
            .:|::.||....|:|.|.|....:.:....|....||.. |....:..:|:||:.:.:...:..:
Mouse   327 MIRIKARYQTVSILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKD 391

  Fly   675 LIRMLCQAEVTR--ENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELN 737
            .:..|..:||.|  :|| ..:||..:|||..::.|::.....:||.|:.|.::.:.||.::.|::
Mouse   392 FLTDLMMSEVDRCGDNE-HLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVD 455

  Fly   738 PTKMDVNDDACTNAEF------LLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERL 796
            |:|       |::|:.      |....:|....|..|....||.:        |.|.|.|..|..
Mouse   456 PSK-------CSSADLPEHQGNLKMCCELAFCKIINSYCVFPREL--------KEVFASWRQECS 505

  Fly   797 VR------TRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGK 855
            .|      .|::|..:|||.||||:::|..|.|:.|.|.....|:|.::||..|||||..:||.|
Mouse   506 SRGRPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSK 570

  Fly   856 EQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGM--FVEQSTNLNSQDTGRELATLHHI 915
            |:||..:|.|:......|..||.::|:....:...|.  ::         |.||||::||.:
Mouse   571 EEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYI---------DLGRELSSLHSL 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722
		SH2_Cterm_RasGAP	252..326	CDD:198217
		PH_RASA1	379..484	CDD:270080	12/58 (21%)
		C2_Ras_p21A1	499..622	CDD:176045	36/131 (27%)
		RasGAP	620..954	CDD:413381	89/313 (28%)
Dab2ip	NP_001107596.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75
		PH-like	75..261	CDD:302622	33/127 (26%)
		C2_SynGAP_like	203..342	CDD:175980	40/143 (28%)
		RasGAP	328..646	CDD:214617	92/321 (29%)
		RasGAP_DAB2IP	333..656	CDD:213338	91/316 (29%)
		DUF3498	646..1150	CDD:288827
		Necessary for interaction with AKT1. /evidence=ECO:0000250	646..943
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..679
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	804..823
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	843..865
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..998
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1034
		TBPIP	<1028..1116	CDD:284512
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1163..1189
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820