DRSC/TRiP Functional Genomics Resources

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Protein Alignment vap and RASAL3

DIOPT Version :10

Sequence 1:NP_523361.1 Gene:vap / 32569 FlyBaseID:FBgn0003969 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001387306.1 Gene:RASAL3 / 64926 HGNCID:26129 Length:1014 Species:Homo sapiens


Alignment Length:514 Identity:146/514 - (28%)
Similarity:222/514 - (43%) Gaps:78/514 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   435 LYQCHDSLWERPYCFQIV----ERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQKKV 495
            ::..|.||...|:|||:.    .|...|.:      |..::   .||..|:    .|....|..|
Human   248 IWPLHPSLLGEPHCFQVTWTGGSRCFSCRS------AAERD---RWIEDLR----RQFQPTQDNV 299

  Fly   496 SRLRELRCLNLHVLEAHRLPFKL--VPHPYCSISLNQVKVGKTRVKIAP-EPVWEEEFVLDDVPP 557
            .  ||...|::.|.||..||...  .|.....:.|:...:.:|..:..| :..|.|.|..:.:||
Human   300 E--REETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFHFEALPP 362

  Fly   558 DVVSLTITLISRGKRGKDSEVAELTIDLSSLKNGQE----TEGWYQLTGMTPMGEWGSLRLRMRY 618
               :..::|..||.....:.:..:.:.|..|...:.    .|.|:.|.| .|.|  .:||.|:|.
Human   363 ---ARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWFPLLG-APAG--AALRARIRA 421

  Fly   619 LDDLIMPCEEYSPLQQLL----------LESELYAVKALAELCHNDRVPLATALLRVFRQEKRET 673
            ....::|.|.|..|.:.|          ||..|.| :|..|        ||.|::||.|...|..
Human   422 RRLRVLPSERYKELAEFLTFHYARLCGALEPALPA-QAKEE--------LAAAMVRVLRATGRAQ 477

  Fly   674 ELIRMLCQAEVTR-ENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELN 737
            .|:..|..||:.| ......|||..:|||..:|.||:.....:||..:.:.|:|:..|.:..|::
Human   478 ALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVD 542

  Fly   738 PTKMDVND---------DACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPT 793
            |:|...::         ::|.... .|.|..|...|.|      |..:..:.|..::|  .|...
Human   543 PSKCPASELPEHQARLRNSCEEPP-RLTIHCLFCTSWF------PAELGIVFSSWREA--CKERG 598

  Fly   794 ERLVRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQY 858
            ..::..|:|...:||||||||:|.|..|||..:.|.....|:|.::||.:|||||...||.||.|
Human   599 SEVLGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAY 663

  Fly   859 MEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLH-HIC 916
            |..:|.|:.::...|..||||::.|:....|.|.       ..|.|...:||.|| .:|
Human   664 MGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGY-------QGSGDLALQLAVLHAQLC 715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vapNP_523361.1 SH2_Nterm_RasGAP 64..166 CDD:198216
SH3_RasGAP 183..241 CDD:212722
SH2_Cterm_RasGAP 252..326 CDD:198217
PH_RASA1 379..484 CDD:270080 13/52 (25%)
C2_Ras_p21A1 499..622 CDD:176045 32/129 (25%)
RasGAP 620..954 CDD:470620 98/318 (31%)
RASAL3NP_001387306.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 52..136
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 151..197
PH_RASAL3 180..321 CDD:270177 24/87 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 209..230
C2 294..>406 CDD:472691 26/116 (22%)
RasGAP_DAB2IP 426..746 CDD:213338 98/315 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 759..888
COG4372 893..>989 CDD:443500
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 990..1014
Blue background indicates that the domain is not in the aligned region.

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