DRSC/TRiP Functional Genomics Resources

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Protein Alignment vap and RASA2

DIOPT Version :10

Sequence 1:NP_523361.1 Gene:vap / 32569 FlyBaseID:FBgn0003969 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001290175.1 Gene:RASA2 / 5922 HGNCID:9872 Length:853 Species:Homo sapiens


Alignment Length:630 Identity:152/630 - (24%)
Similarity:261/630 - (41%) Gaps:171/630 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   444 ERPYCFQIVERAL-PCLATVTYLCAPSQESYVEWI----NSLKAQ-------------C------ 484
            |..|..|:||::| |..:...|...|....|:.:.    |.|:..             |      
Human    71 EEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE 135

  Fly   485 --------DSQLSRAQKKVS---RLREL--------RCLNLHVLEAHRLPFKLVP----HPYCSI 526
                    ||. |..|.||.   :|.||        :.|.:|:...|.||  |:.    .||.::
Human   136 TWFSLQPVDSN-SEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLP--LINGQSCDPYATV 197

  Fly   527 SL-----NQVKVGKTRV-KIAPEPVWEE----------------EFVLDDVPPDVVSLTITLISR 569
            ||     |..|  ||:| |....|.:.|                :|.:::...:.:.:.|.|.:.
Human   198 SLVGPSRNDQK--KTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNN 260

  Fly   570 GKRGKDSEVAELTIDLSSLKNGQETEGWYQL------TGMTPMGEWGSLRLRMRYLDDLIMPCEE 628
            |...:|..:.|:.:.::.|:.....:.||.|      ...:...:.|||||.:.|.:|.::|.|.
Human   261 GNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEY 325

  Fly   629 YSPLQQLLLES-ELYAVKA-----LAELC---------------HNDR-VPLATALLRVFRQEKR 671
            |.||:.|||:| ::..:.|     |:|:|               |:|: ||.|||:..:   :.:
Human   326 YGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAEL---DLK 387

  Fly   672 ETELIRMLCQAEVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAEL 736
            :|:              :..|:|||.||||..:|..|:.....:|:..:...:..|.:|.:|.|:
Human   388 DTQ--------------DANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEI 438

  Fly   737 NPTKMDVNDDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVRTRV 801
            :|.|:...|:...|.|.|...:|.:..:|..|..:||..:..|...|::....::|.:..|:...
Human   439 DPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSA 503

  Fly   802 VSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGG--------KEQY 858
            ||.|:|||....|:::|..|.|....|.....|:|.:::|.:|.|.:   :|.        ||.:
Human   504 VSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGS---WGSLSKSKSSFKETF 565

  Fly   859 MEVVNPFILKNKERMIV----FLDQLSSV-----NDPNQPL----GMFVEQS---TNLNSQD--- 904
            |  ...|.:..:|..|:    |||::||.     :..::|:    |...:::   |.:..::   
Human   566 M--CEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNFKK 628

  Fly   905 -----TGRELATLHHICVSHSQELHE---------LSNILSIKKL 935
                 |.||| |.|     ...|..|         :.|||:::||
Human   629 RWFCLTSREL-TYH-----KQPEFIERKDAIYTIPVKNILAVEKL 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vapNP_523361.1 SH2_Nterm_RasGAP 64..166 CDD:198216
SH3_RasGAP 183..241 CDD:212722
SH2_Cterm_RasGAP 252..326 CDD:198217
PH_RASA1 379..484 CDD:270080 12/57 (21%)
C2_Ras_p21A1 499..622 CDD:176045 36/162 (22%)
RasGAP 620..954 CDD:470620 96/379 (25%)
RASA2NP_001290175.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
C2A_RasA2_RasA3 39..159 CDD:176046 19/88 (22%)
C2B_RasA3 172..314 CDD:175977 33/145 (23%)
RasGAP_RASA2 323..593 CDD:213342 78/291 (27%)
PH_GAP1m_mammal-like 590..726 CDD:241521 18/84 (21%)
BTK 711..746 CDD:128417
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 828..853
Blue background indicates that the domain is not in the aligned region.

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