DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vap and RASA1

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_002881.1	Gene:	RASA1 / 5921	HGNCID:	9871	Length:	1047	Species:	Homo sapiens

Alignment Length:	982	Identity:	446/982 - (45%)
Similarity:	611/982 - (62%)	Gaps:	81/982 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GSPTGCSDDGNLAGLGG--MTGLGGIMA--------------PGG-------------------- 48
            |..|.....|..||:.|  :.|..|.||              |||
Human    88 GGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLPPPPYLPPLGAGLGT 152

  Fly    49 IDLGDLAQELDHDEFDGPHMLNGERPAI--IAPPESEWYHGRLDRYSAESRLRGSSKLGSYLVRE 111
            :|.|        |..|||. ...|..||  .|||.::||||:|||..||.|||.:.|.||||:||
Human   153 VDEG--------DSLDGPE-YEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRE 208

  Fly   112 SDRKPGSYVLSYYGRTG-INHFRITAVCGDFYIGGRQFISLSDLVGYYTSCSDLLKRERLAIPVA 175
            |||:|||:|||:..:.. :|||||.|:|||:|||||:|.|||||:|||:..|.|||.|:|..|||
Human   209 SDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVA 273

  Fly   176 PPEPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMIFRELVDD 240
            |||||.|::||.|||||||:|:|||:||.|||:|.|||::.|||:|||..||.|||:|..:||::
Human   274 PPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEE 338

  Fly   241 LDVSIDPNTVFPWFHPNCTKNEAVDMLVKAGP-GSFLVRPSDNSPGDYSLFFHINNQIQRFRI-E 303
            :....||:....|||...:|.||.::|:..|. .|||||||||:||||||:|..|..||||:| .
Human   339 VGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICP 403

  Fly   304 KKGVRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPVVNGIQPEFNQQYVVEKAAE--KIYATL 366
            ....:::||||.:..:..:|:.|||||||||:.|..||     |..:|:.|:....:  :||.|:
Human   404 TPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPV-----PMQDQEQVLNDTVDGKEIYNTI 463

  Fly   367 -RECRDQIGLKKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCFYDNPKK-TKPKGLID 429
             |:.:|..    .|.|...|:|.||. |..:||.|||.|  :||:.||.::::.|: ||||||||
Human   464 RRKTKDAF----YKNIVKKGYLLKKG-KGKRWKNLYFIL--EGSDAQLIYFESEKRATKPKGLID 521

  Fly   430 LSCAYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQKK 494
            ||...:|..||||:.||.|||||.:.......:.|....:.|...:|:..|:|.|:.:.|.....
Human   522 LSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTS 586

  Fly   495 VSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPVWEEEFVLDDVPPDV 559
            ..|||::..|.||:.|||:||.|...:|||:|.||.|:|.||..:....|||.||||.||:|||:
Human   587 NKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDI 651

  Fly   560 VSLTITLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMG--EWGSLRLRMRYLDDL 622
            ....|||.::.|:.||.::..:...||.|:.|..|:.|:.|:...|:.  |.||||:|.||..:.
Human   652 NRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEK 716

  Fly   623 IMPCEEYSPLQQLLLESELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRMLCQAEVTRE 687
            |||.||||..::|:|:.||:.|.||:.:|..||..||:.|||:|..||.|:.|:..|...|::.|
Human   717 IMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISME 781

  Fly   688 NETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDACTNAE 752
            :|.|||||..:||:|||:.||:...:.|:..|:.:::.:|:|||||.||:|:|::.|:|..||..
Human   782 DEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLT 846

  Fly   753 FLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVRTRVVSGFIFLRLLCPALLN 817
            .||.||..:.:.||.:.:..|..:|:|..||||:|..||||...:||||||||:||||:|||:||
Human   847 HLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILN 911

  Fly   818 PRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLSS 882
            ||.|.::|::|...|.|:|::|||.:||||||:|||.||.|||.|||||..||.|||:|||:|.:
Human   912 PRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGN 976

  Fly   883 VNDPNQPLGMFVEQSTNLNSQDTGRELATLHHICVSHSQELHELSNILS-----IKKLVTVTDML 942
            |  |..|      .:|..:..|..|:||.||.|||:||.||..|||...     :|||:.:|::|
Human   977 V--PELP------DTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELL 1033

  Fly   943 TKHKLKY 949
            .:.:.:|
Human  1034 QQKQNQY 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216	62/104 (60%)
		SH3_RasGAP	183..241	CDD:212722	36/57 (63%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	35/75 (47%)
		PH_RASA1	379..484	CDD:270080	45/105 (43%)
		C2_Ras_p21A1	499..622	CDD:176045	54/124 (44%)
		RasGAP	620..954	CDD:413381	159/335 (47%)
RASA1	NP_002881.1	SH2_Nterm_RasGAP	161..264	CDD:198216	61/103 (59%)
		SH3_RasGAP	281..339	CDD:212722	36/57 (63%)
		SH2_Cterm_RasGAP	350..426	CDD:198217	35/75 (47%)
		PH_RASA1	489..576	CDD:270080	38/88 (43%)
		C2_Ras_p21A1	591..716	CDD:176045	54/124 (44%)
		RasGAP_p120GAP	714..1045	CDD:213340	159/335 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152774
Domainoid	1	1.000	124	1.000	Domainoid score	I5563
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2168
Inparanoid	1	1.050	796	1.000	Inparanoid score	I514
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48483
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0006956
OrthoInspector	1	1.000	-	-		oto89782
orthoMCL	1	0.900	-	-		OOG6_105831
Panther	1	1.100	-	-	LDO	PTHR10194
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5047
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770