Protein Alignment vap and rasa4

DIOPT Version :10

• Sequence 1: NP_523361.1
• Gene: vap / 32569
• FlyBaseID: FBgn0003969
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: XP_005172052.2
• Gene: rasa4 / 567599
• ZFINID: ZDB-GENE-060526-349
• Length: 806
• Species: Danio rerio
• Alignment Length: 552
• Identity: 132/552 - (23%)
• Similarity: 242/552 - (43%)
• Gaps: 118/552 - (21%)

  Fly   476 WINSLKAQCDSQL-SRAQKKVSRL------RELRCLNLHVLEAHRLPFK---LVPHPYCSISLNQ 530
            |:|..:...|.:: .....::|.|      |:|.|   .||||..|..|   ....|:..:..|
Zfish   104 WMNLTEIDPDEEVQGEIHLQISVLGDGDIPRKLCC---QVLEARDLAKKDRNGASDPFVRVRYN- 164

  Fly   531 VKVGKTR----VKIAPEPVWEE--EFVLDDVPPD-VVSLTI---TLISRGKRGKDSEVAELTIDL 585
               |||.    ||.:..|.|.|  ||.||:...| ::|:.:   .|:||     :..:.::..::
Zfish   165 ---GKTYESSVVKKSCYPRWNESFEFELDEALTDSLLSVEVWDWDLVSR-----NDFLGKVLFNI 221

  Fly   586 SSLKNGQETEGWYQLTGMTP--------MGEWGSLRLRMRYLDDLIMPCEEYSPLQQLLLES--- 639
            :.|::..:.|||::|   .|        .|..|||||.:|..|::::|...|.||.:||.:|
Zfish   222 NKLQSALQEEGWFRL---GPDKSKHSEYEGTLGSLRLHLRLRDEVVLPSSHYKPLTELLSQSVGS 283

  Fly   640 --------------ELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRMLCQAEVTRENET 690
                          |....::..|:.:|        |:::|..:....|.:.:|.:.|:.:..|.
Zfish   284 QLNGNWPDFIMLIDETTTAESRQEVANN--------LVKLFLGQGLVKEFLDVLFKLELDKTTEP 340

  Fly   691 TTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDACT------ 749
            .||||..|||:..|:.:::.....:|...:...:.||.|.|:..||:|:|:::.:..|.
Zfish   341 NTLFRSNSLASKSMESFLKVAGMQYLHRLLGPIINRIFEEKKYVELDPSKVELKEAGCAGLHRQQ 405

  Fly   750 -------NAEFLLQ--ILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTE--RLVRTRVVS 803
                   .:..|||  :.:|:| ||..|...||..:..:...|...|..::|..  |.|:...|:
Zfish   406 TESDVIQQSSSLLQSYLSELLT-SILQSASYCPLLICQVFHQLYLRVQERFPDPEYRKVKFIAVT 469

  Fly   804 GFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANL--IEFGGKEQYMEVVNPFI 866
            .|:.||.:.||:::|:.|.|..:......:|:|:::||.:|.:.|:  :....||.:|..:.|.|
Zfish   470 SFLCLRFISPAIMSPKLFHLREKHADARTSRTLLLLAKAVQTIGNMDTLACCSKEPWMVRLQPAI 534

  Fly   867 LKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNSQDTGRE----------------------- 908
            .:...::..|:.:|.:.::...     :|..|.::.|....|
Zfish   535 QQGITQLKDFITRLVNCHESED-----LELQTRMSLQCGTMEKEGFLFLHRTKDKCMPMTSPFKK 594

  Fly   909 -LATLHHICVSHSQELH-ELSNILSIKKLVTV 938
             ..||....:|:|:.|| :.|:.:|:.|:..|
Zfish   595 YYVTLSKDTLSYSRTLHSKKSSSISLPKIRAV 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_523361.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722
		SH2_Cterm_RasGAP	252..326	CDD:198217
		PH_RASA1	379..484	CDD:270080	2/7 (29%)
		C2_Ras_p21A1	499..622	CDD:176045	42/143 (29%)
		RasGAP	620..954	CDD:470620	86/380 (23%)
rasa4	XP_005172052.2	None