Protein Alignment vap and rasa1b

DIOPT Version :10

• Sequence 1: NP_523361.1
• Gene: vap / 32569
• FlyBaseID: FBgn0003969
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: XP_001921722.2
• Gene: rasa1b / 564822
• ZFINID: ZDB-GENE-090311-50
• Length: 1032
• Species: Danio rerio
• Alignment Length: 982
• Identity: 418/982 - (42%)
• Similarity: 605/982 - (61%)
• Gaps: 66/982 - (6%)

  Fly    13 VIQKD-KPGSPTGCSDDGNLAG----LGGMTGLG-GIMAP------GGIDLGDLAQEL------- 58
            :..|| :||:....|....::.    ||..:|:| |:..|      |.:....|:.|:
Zfish    65 IFGKDPRPGTVMFASKGAGVSAGHVILGSFSGVGRGMSDPQHEGAVGWVPSASLSPEMCLAAPSF 129

  Fly    59 -------DHDEFDGPHMLNGERPAII----APPESEWYHGRLDRYSAESRLRGSSKLGSYLVRES 112
                   :.|..|...:  ||...|:    |||.::||||:|||..||.||......||||:|||
Zfish   130 RPLSIVEEGDTLDVQEI--GEDEEIVLTLTAPPPNQWYHGKLDRMIAEERLLQVRAAGSYLIRES 192

  Fly   113 DRKPGSYVLSYYGRTG-INHFRITAVCGDFYIGGRQFISLSDLVGYYTSCSDLLKRERLAIPVAP 176
            ||:|||:|||:...|. ::||||.|:|||:|||||:|.|||||:|||:..|.|||.|:|..||||
Zfish   193 DRRPGSFVLSFLSMTNTVSHFRIIAMCGDYYIGGRRFSSLSDLIGYYSYVSCLLKGEKLISPVAP 257

  Fly   177 PEPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMIFRELVDDL 241
            ||||.|::||.|||||||:|||||:||.|||.|.|||::.|||||||..||.|||:|..:||.::
Zfish   258 PEPVEDRRRVRAILPYTKVPETDEISFFKGDTFIVHNELEDGWLWVTNVRTDEQGLIVEDLVKEV 322

  Fly   242 DVSIDPNTVFPWFHPNCTKNEAVDMLVKAGP-GSFLVRPSDNSPGDYSLFFHINNQIQRFRIE-K 304
            ....||:....|||...:|.||.::|:..|. |||||||||::||||||:|.....||||:|. .
Zfish   323 GREEDPHEGKAWFHGKISKQEAYNLLMTVGQVGSFLVRPSDSTPGDYSLYFRTTETIQRFKISPT 387

  Fly   305 KGVRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPVVNGIQPEFNQQYVVEKAAE--KIYATL- 366
            ...:::||||.:..:|.:|..||:|||||||||...:  .:|   :|:.|:....|  :||.|:
Zfish   388 PSNQFMMGGRYYNSIDDIIEHYRREQIVEGHSLKDAL--SVQ---HQEQVLTDIVEGKEIYNTIR 447

  Fly   367 RECRDQIGLKKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCFYDNPKK-TKPKGLIDL 430
            |:.:|..    .|.|...|::.....|..:||.|||.|  :|:::||.::::.|: |||||||||
Zfish   448 RKTKDAF----YKNIVKKGYILFNKGKGKRWKNLYFIL--EGNDSQLIYFESEKRATKPKGLIDL 506

  Fly   431 SCAYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQK-K 494
            |...:|:.|||::.||.|||||.:.......:.|....:.|...:|:..|:..|::.....|. .
Zfish   507 SVCSVYEVHDSMFGRPNCFQIVVQHFSEEQCIFYFAGETPEQAEDWMKCLQTFCNNLRKPVQPCS 571

  Fly   495 VSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPVWEEEFVLDDVPPDV 559
            ..|||::..|.|:|.|||:||.|...:.||:|.||.::|.||..:....|||.|||:.||:..::
Zfish   572 NKRLRQVSSLFLNVEEAHKLPSKHFTNAYCNIYLNSIQVAKTHPREGQNPVWTEEFIFDDLSSEI 636

  Fly   560 VSLTITLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEW--GSLRLRMRYLDDL 622
            ....|:|.::.|:.|::::..:...|..|:.||..:.|:.|:...|:...  .|||||:||..:.
Zfish   637 NRFEISLSNKTKKSKENDILFMCCPLCRLQRGQIIDEWFPLSSHVPLKNVMPSSLRLRVRYSVEK 701

  Fly   623 IMPCEEYSPLQQLLLESELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRMLCQAEVTRE 687
            |||.|.||.|::|::..:|:.|.|||.:|...|..||:.|||:||.:.:|.:|:|.|...|:..|
Zfish   702 IMPVEVYSELKELVVLRDLHVVSALAHVCGQKRTLLASVLLRIFRHQNQEAQLLRELNDREICAE 766

  Fly   688 NETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDACTNAE 752
            :|.|||||..:||:|||:.||:...:.|:..|:.:::.:|::|:||.||||:|::.|:|...|..
Zfish   767 DEATTLFRATTLASTLMEQYMKATATPFVHHALKDSILKIMDSRQSCELNPSKLEKNEDVNVNLA 831

  Fly   753 FLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVRTRVVSGFIFLRLLCPALLN 817
            .||.|:..:.:.||.:.:..|..:|||..||||||..|||....:||||||||:||||:|||::|
Zfish   832 HLLSIVSELLEKIFMAAEILPPTLRFIYGCLQKAVEQKWPRNTTMRTRVVSGFVFLRLICPAIVN 896

  Fly   818 PRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLSS 882
            ||.|.::::.|...|:|:|.:|||.:||||||:|||.||.|||.|||||..||.|||:|||:|..
Zfish   897 PRIFNIIADPPSPVASRTLTLVAKAVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMILFLDELGK 961

  Fly   883 VNDPNQPLGMFVEQSTNLNSQDTGRELATLHHICVSHSQELHELSNILS-----IKKLVTVTDML 942
            |::..:|...|        :.|..|:||.||.:||:|..||..|||...     :|||:.|:::|
Zfish   962 VSELPEPTEHF--------NTDVARDLAALHQLCVTHLDELRTLSNDRGAQQHVLKKLLAVSELL 1018

  Fly   943 TKHKLKY 949
            .:.:.:|
Zfish  1019 QQTQGQY 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_523361.1	SH2_Nterm_RasGAP	64..166	CDD:198216	58/106 (55%)
		SH3_RasGAP	183..241	CDD:212722	38/57 (67%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	35/75 (47%)
		PH_RASA1	379..484	CDD:270080	39/105 (37%)
		C2_Ras_p21A1	499..622	CDD:176045	44/124 (35%)
		RasGAP	620..954	CDD:470620	150/335 (45%)
rasa1b	XP_001921722.2	SH2	148..247	CDD:472789	56/98 (57%)
		SH3_RasGAP	264..322	CDD:212722	38/57 (67%)
		SH2_Cterm_RasGAP	334..409	CDD:198217	35/74 (47%)
		PH_RASA1	456..560	CDD:270080	39/105 (37%)
		C2_Ras_p21A1	576..701	CDD:176045	44/124 (35%)
		RasGAP_p120GAP	700..1029	CDD:213340	150/334 (45%)