DRSC/TRiP Functional Genomics Resources

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Protein Alignment vap and Rasal1

DIOPT Version :10

Sequence 1:NP_523361.1 Gene:vap / 32569 FlyBaseID:FBgn0003969 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001101805.1 Gene:Rasal1 / 360814 RGDID:1311820 Length:801 Species:Rattus norvegicus


Alignment Length:476 Identity:141/476 - (29%)
Similarity:218/476 - (45%) Gaps:67/476 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   476 WINSLKAQCDSQLSRAQKKVSRLREL------RCLNLHVLEAHRL----------PFKLVPHPYC 524
            |||..:...|.::   |.:|....:|      |||..||.:|..|          ||..|  .:.
  Rat   104 WINLSRVDPDEEV---QGEVCLAVKLLEDARGRCLRCHVRQARDLAPRDISGTSDPFARV--FWG 163

  Fly   525 SISLNQVKVGKTRVKIAPEPVWEEEFVLDDVPPDVVSLTITLISRGKRGKDSEVAELTIDLSSLK 589
            |.||....:.|||.     |.|:|...|.:.|.....|.:.|......||:..:..:.....:|:
  Rat   164 SRSLETSTIKKTRF-----PHWDEVLELREAPGTTSPLRVELWDWDMVGKNDFLGMVEFTPQTLQ 223

  Fly   590 NGQETEGWYQLTGMTPM-------GEWGSLRLRMRYLDDLIMPCEEYSPLQQLLLES-------- 639
            . :...||::|   .|.       |..|:|||::|..:|.::|.:.|.||.:|||||        
  Rat   224 Q-KPPNGWFRL---LPFPRAEDSGGSLGALRLKVRLTEDRVLPSQYYQPLMELLLESVQGPAEED 284

  Fly   640 ELYAVKALAELCHND-RVPLATALLRVFRQEKRETELIRMLCQAEVTRENETTTLFRGASLATTL 703
            ....:..|.||...| |..|||.|:::|.........:..|.:.||.|.|:..||||..|||:..
  Rat   285 TTSPLALLEELASGDCRQDLATKLVKLFLGRGLAGPFLDYLTRREVARTNDPNTLFRSNSLASKS 349

  Fly   704 MDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDAC--------------TNAEFL 754
            |:.:|:.....:|...:...:.|:.|.|:..||:|:|||:|....              |:...|
  Rat   350 MEQFMKLVGMRYLHEVLRPVISRVFEEKKYMELDPSKMDLNRSRRISFKGTPTEEQVRETSLGLL 414

  Fly   755 LQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWP--TERLVRTRVVSGFIFLRLLCPALLN 817
            ...|..|..:|.:|...||..:|.....||:.|..::|  ..:.|:....|||:|||...||:|.
  Rat   415 TGYLGSVVDAIVSSAGRCPLALRLAFKQLQQCVEKRFPGMEHQDVKYLATSGFLFLRFFAPAILT 479

  Fly   818 PRQFGLVSETPPMAATRSLVMVAKCLQNLANL-IEFG-GKEQYMEVVNPFILKNKERMIVFLDQL 880
            |:.|.|.........:|||:::||.:|::.|| .:.| ||||::..::||:|::..|:..|||||
  Rat   480 PKLFDLRDHHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKEQWLAPLHPFLLQSISRVRDFLDQL 544

  Fly   881 SSVNDPNQPLG---MFVEQST 898
            ..|:...:..|   ..|:.||
  Rat   545 VDVDGDEEAGGSTCALVQPST 565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vapNP_523361.1 SH2_Nterm_RasGAP 64..166 CDD:198216
SH3_RasGAP 183..241 CDD:212722
SH2_Cterm_RasGAP 252..326 CDD:198217
PH_RASA1 379..484 CDD:270080 3/7 (43%)
C2_Ras_p21A1 499..622 CDD:176045 37/145 (26%)
RasGAP 620..954 CDD:470620 98/309 (32%)
Rasal1NP_001101805.1 C2 6..126 CDD:472691 6/24 (25%)
C2 134..254 CDD:472691 34/130 (26%)
RasGAP_RASAL 262..548 CDD:213337 92/285 (32%)
PH-like 552..689 CDD:473070 4/14 (29%)
BTK 681..709 CDD:459937
Blue background indicates that the domain is not in the aligned region.

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