DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vap and Rasal3

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_006524475.1	Gene:	Rasal3 / 320484	MGIID:	2444128	Length:	1065	Species:	Mus musculus

Alignment Length:	921	Identity:	229/921 - (24%)
Similarity:	341/921 - (37%)	Gaps:	238/921 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 SRLRGSSKLGSYLVRESD--RKPG--SYVLSYYGRTG------INHFRITAVCGDFYIGGRQFIS 150
            ||.|.||.:...|..|.|  .:|.  |.:.||...||      ...||    .|.|...||....
Mouse    15 SRSRDSSAMDPPLQSEEDSQTQPSLPSPLTSYRWHTGGSGEKAAGGFR----WGRFAGWGRALSH 75

  Fly   151 LSDLVGYYTSCSDLLKRERLAIP--------------------VAPPEPVNDKKRVVAILPYTKM 195
            ...:|....:...|.:|...|.|                    |||.||          .|..|.
Mouse    76 QEPMVNSQPAPRSLFRRVLSAPPKESRSNRLRFSKTLWGRHKNVAPLEP----------KPNPKA 130

  Fly   196 PETDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMIFRELVDDLDVSIDPNTVFPWFHPNCTK 260
            ||..:.:...|               |....:|...::  :|..:|::..||
Mouse   131 PERSKQAMVPG---------------VKGQLSGVSSLL--QLQPELELVADP------------- 165

  Fly   261 NEAVDMLVKAGPGSFLVRPSDNSPGDYSLFFHINNQIQRFRI---------EKKGVRYL-MGGRT 315
                |:.|...|..    |:.:.|        :.| |..|.:         |::|.|.: :|..:
Mouse   166 ----DLPVAQIPEP----PTPDMP--------VWN-IDGFTLLEGKLVMLGEEEGPRQIRVGSAS 213

  Fly   316 FE-CLDAVINRYRKEQIVEGHSLNHPVVNGIQPE---FNQQYVVEKAAEKIYATLRECRDQIGLK 376
            .| .:.|.:...:......|.:         :||   .||.:.|.|.                ||
Mouse   214 SENSMQAALGNLKDAVRTPGKT---------EPEAAGSNQVHNVRKL----------------LK 253

  Fly   377 KIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCFYDNPKKTKPKGL-----------IDL 430
            ::|        .||..|                 ::|..| .|:...|..|           :||
Mouse   254 RLK--------EKKRAK-----------------SELGAY-TPRDGPPSALGSRESLATLSELDL 292

  Fly   431 SC---AYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQ 492
            ..   ..::..|.||...|||||:....    .::.:.|..|.|. ..||..|:    .|...:|
Mouse   293 GAERDVRVWPLHPSLLGEPYCFQVTWAG----GSLCFSCRSSAER-DRWIEDLR----RQFQPSQ 348

  Fly   493 KKVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAP-EPVWEEEFVLDDVP 556
            ..|.| :|: .|.:.|.||..||...||.....:.|:...:.:|..:..| :..|.|.|..:.:|
Mouse   349 DNVER-QEM-WLTVWVHEAKGLPRATVPGVRAELWLDGALLARTAPRAGPGQLFWAERFHFEALP 411

  Fly   557 PDVVSLTITLISRGKRGKDSEVAELTIDLSSLKNGQET--EGWYQLTGMTPMGEWGSLRLRMRYL 619
            | ...|::.|.|.|..|.......|.:|..|:......  |.|:.:.| .|.|.....|:|:|.|
Mouse   412 P-ARRLSLRLRSAGPAGATVGRVVLELDEVSIPRAPAAGLERWFPVLG-APAGAVLRARIRVRCL 474

  Fly   620 DDLIMPCEEYSPLQQLL----------LESELYAVKALAELCHNDRVPLATALLRVFRQEKRETE 674
              .::|.|.|..|.:.|          ||..|.| :|..|        ||.|::||.|...|...
Mouse   475 --RVLPSERYKELAEFLTFHYARLCGALEPALSA-QAKEE--------LAAAMVRVLRATGRAQA 528

  Fly   675 LIRMLCQAEVTR-ENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNP 738
            |:..|..||:.| ......|||..:|||..:|.||:.....:||..:.:.|:.:..|.:..|::|
Mouse   529 LVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQEYLQDTLGQVVRCLCASTEDCEVDP 593

  Fly   739 TKMDVNDDACTNAEF------LLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLV 797
            :|       |...|.      |....:.|.::|..|.:..|..:..:.|..::|..|:  ....:
Mouse   594 SK-------CPTPELPKHQARLRDSCEEVFENIIHSYNCFPAELGSVFSSWREACKAR--GSEAL 649

  Fly   798 RTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQYMEVV 862
            ..|:|...:||||||||:|.|..|||..|.|.....|:|.::||.:|||||...||.||.||..:
Mouse   650 GPRLVCASLFLRLLCPAILAPSLFGLAPEHPAPGPARTLTLIAKVIQNLANCAPFGEKEAYMAFM 714

  Fly   863 NPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLH-HICVSHSQ----- 921
            |.|:..:...|..||||:::|:....|.|.       ..|.|...:||.|| .:|...::
Mouse   715 NSFLEDHGPAMQHFLDQVATVDADTTPSGY-------QGSGDLALQLAVLHVQLCTIFAELDQKT 772

  Fly   922 --ELHELSNIL 930
              .|..|..||
Mouse   773 QDSLEPLPTIL 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216	22/79 (28%)
		SH3_RasGAP	183..241	CDD:212722	8/57 (14%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	14/84 (17%)
		PH_RASA1	379..484	CDD:270080	25/118 (21%)
		C2_Ras_p21A1	499..622	CDD:176045	34/125 (27%)
		RasGAP	620..954	CDD:413381	102/336 (30%)
Rasal3	XP_006524475.1	PH-like	227..372	CDD:388408	45/206 (22%)
		C2	346..478	CDD:387358	37/137 (27%)
		RasGAP_DAB2IP	470..793	CDD:213338	105/341 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820