DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vap and Rasal3

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_006241121.1	Gene:	Rasal3 / 314596	RGDID:	1309019	Length:	1038	Species:	Rattus norvegicus

Alignment Length:	665	Identity:	176/665 - (26%)
Similarity:	270/665 - (40%)	Gaps:	118/665 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 EKKGVRYL-MGGRTFE-CLDAVINRYRKEQIVEGHSLNHPV--VNGIQPE---FNQQYVVEKAAE 360
            |::|.|.: ||..:.| .:.|.:.           :|..||  ...|:||   .||.:.|.|.
  Rat   173 EEEGPRQIRMGSASSESSMQAALG-----------NLKDPVRTPGKIEPEATGSNQVHNVRKL-- 224

  Fly   361 KIYATLRECRDQIGLKKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCFYDNPKKTKPK 425
                          ||::|        .||..|:    :|......||..:.|   .:.:.....
  Rat   225 --------------LKRLK--------EKKRAKS----ELGAHTPRDGPSSAL---GSRESLATL 260

  Fly   426 GLIDLSC---AYLYQCHDSLWERPYCFQIV----ERALPCLATVTYLCAPSQESYVEWINSLKAQ 483
            ..:||..   ..::..|.||...|||||:.    .|...|         .|......||..|:
  Rat   261 SELDLGVERDVRVWPLHPSLLGEPYCFQVTWAGGSRCFSC---------RSSAERDRWIEDLR-- 314

  Fly   484 CDSQLSRAQKKVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPV-WE 547
              .|...:|..|.  |:...|.:.|.||..||....|.....:.|:...:.:|..:..|:.: |.
  Rat   315 --RQFQPSQDNVE--RQETWLTVWVHEAKGLPRAAAPGVRAELWLDGALLARTAPRAGPDQLFWA 375

  Fly   548 EEFVLDDVPPDVVSLTITLISRGKRGKDSEVAELTIDLSSLK----NGQETEGWYQLTGMTPMGE 608
            |.|..:.:||   :..::|..||.....:.|..:.::|..:.    .....|.|:.:.| .|.|.
  Rat   376 ERFHFEALPP---ARRLSLRLRGAGPAGATVGRVVLELDEVSIPRAPAAGLERWFPVLG-APAGA 436

  Fly   609 WGSLRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKALA---ELCHNDRVPLATALLRVFRQEK 670
            ....|:|:|.|  .::|.|.|..|.:.|  :..||...:|   .|....:..||.|::||.|...
  Rat   437 VLRARIRVRCL--RVLPSERYKELAEFL--TFHYARLCMALEPALSAQAKEELAAAMVRVLRATG 497

  Fly   671 RETELIRMLCQAEVTR-ENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSA 734
            |...|:..|..||:.| ......|||..:|||..:|.||:.....:||..:.:.|:.:..|.:..
  Rat   498 RAQALVTDLGTAELERCGGREALLFRENTLATKAIDEYMKLVAQEYLQETLGQVVRSLCASTEDC 562

  Fly   735 ELNPTKMDVNDDACTNAEF------LLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPT 793
            |::|:|       |...|.      |....:.|.::|..|.:..|..:..:.|..::|..|:  .
  Rat   563 EVDPSK-------CPTPELPKCQARLRSSCEEVFENIIHSYNYFPAELGTVFSNWREACKAR--G 618

  Fly   794 ERLVRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQY 858
            ...:..|:|...:||||||||:|.|..|||..|.|.....|:|.::||.:|||||...||.||.|
  Rat   619 SEALGPRLVCASLFLRLLCPAILAPSLFGLAPEHPAPGPARTLTLIAKVIQNLANCAPFGEKEAY 683

  Fly   859 MEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLH-HICVSHSQ- 921
            |..:|.|:..:...|..||||::.|:....|.|.       ..|.|...:||.|| .:|...::
  Rat   684 MVFMNSFLEDHGPAMRHFLDQVAMVDTDTTPSGY-------QGSGDLALQLAVLHVQLCTIFAEL 741

  Fly   922 ------ELHELSNIL 930
                  .|..|..||
  Rat   742 DQKTRDSLEPLPTIL 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722
		SH2_Cterm_RasGAP	252..326	CDD:198217	7/24 (29%)
		PH_RASA1	379..484	CDD:270080	24/111 (22%)
		C2_Ras_p21A1	499..622	CDD:176045	30/127 (24%)
		RasGAP	620..954	CDD:413381	100/329 (30%)
Rasal3	XP_006241121.1	PH-like	200..346	CDD:302622	45/191 (24%)
		C2	319..451	CDD:301316	32/139 (23%)
		RasGAP_DAB2IP	443..766	CDD:213338	103/334 (31%)
		Rep_3	<775..882	CDD:302843
		TMF_DNA_bd	913..973	CDD:289127
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820