Protein Alignment vap and Rasal2

DIOPT Version :10

• Sequence 1: NP_523361.1
• Gene: vap / 32569
• FlyBaseID: FBgn0003969
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: XP_008767860.2
• Gene: Rasal2 / 304893
• RGDID: 1307566
• Length: 1289
• Species: Rattus norvegicus
• Alignment Length: 587
• Identity: 147/587 - (25%)
• Similarity: 255/587 - (43%)
• Gaps: 113/587 - (19%)

  Fly   365 TLRECRDQI-GLKKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCF---YDNPKKTKPK 425
            :||...|:. ||.|:|..:.|.                 :|::..|..: |.   ...|...||
  Rat   217 SLRNADDRSRGLPKLKESRSHE-----------------SLLSPCSAVE-CLDLGRGEPVSVKP- 262

  Fly   426 GLIDLSCAYLYQCHDSLWERPYCFQIVERALPCLATVTYL-------CAPSQESYVEWINSLKAQ 483
                        .|.|:..:.:||:           ||||       |..:.|. .:|:.:|:..
  Rat   263 ------------LHSSILGQDFCFE-----------VTYLSGSKCFSCNSASER-DKWMENLRRT 303

  Fly   484 CDSQLSRAQKKVSRLRELRCLNLHVLEAHRL-PFKLVPHPYCSISLNQVKVGKTRVKIAPEPV-W 546
            ........::..:.||      |.::||..| |.|..   :|.:.|:.....:|..|...:.: |
  Rat   304 VQPNKDNCRRAENVLR------LWIIEAKDLAPKKKY---FCELCLDDTLFARTTSKTKADNIFW 359

  Fly   547 EEEFVLDDVPPDVVSLTITLI----SRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTP-M 606
            .|.|....:|| :.|:|:.:.    .:.|:.|::.|..:.|..:|:...|..|.||.::..|| .
  Rat   360 GEHFEFYSLPP-LHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNK 423

  Fly   607 GEWG--SLRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKALAELCH-NDRVPLATALLRVFRQ 668
            |:.|  |:|::.|:....|:|.|:|....:.:..:.......|..:.. .::..||.||:.:.:.
  Rat   424 GKTGGPSIRIKSRFQTITILPMEQYKEFAEFITSNYTMLCSVLEPVISVRNKEELACALVHILQS 488

  Fly   669 EKRETELIRMLCQAEVTRENETTTL-FRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQ 732
            ..|..:.:..|..:||.|..|...| ||..::||..::.|::.....:|..|:.|.::.:.||.:
  Rat   489 TGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDE 553

  Fly   733 SAELNPTKMDVNDDACTNAEF------LLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKW 791
            :.|::|:|       |:::|.      |....:|....|..|....||.:        |.|.|.|
  Rat   554 NCEVDPSK-------CSSSELTDHQSNLRMCCELAFCKIINSYCVFPREL--------KEVFASW 603

  Fly   792 PTERLVR------TRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLI 850
            ..:.|.|      .|::|..:|||.||||:::|..|.|:.|.|....:|:|.::||.:|||||..
  Rat   604 KQQCLNRGKQDLSERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFA 668

  Fly   851 EFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGM--FVEQSTNLNSQDTGRELATLH 913
            :||.||:||..:|.|:......|..||.::|:.:..:...|.  ::         |.||||:.||
  Rat   669 KFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYI---------DLGRELSVLH 724

  Fly   914 HI 915
            .:
  Rat   725 SL 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_523361.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722
		SH2_Cterm_RasGAP	252..326	CDD:198217
		PH_RASA1	379..484	CDD:270080	20/114 (18%)
		C2_Ras_p21A1	499..622	CDD:176045	34/131 (26%)
		RasGAP	620..954	CDD:470620	86/312 (28%)
Rasal2	XP_008767860.2	PH-like	181..364	CDD:473070	40/198 (20%)
		C2_SynGAP_like	306..445	CDD:175980	36/148 (24%)
		RasGAP_DAB2IP	436..766	CDD:213338	87/315 (28%)
		DUF3498	756..1232	CDD:463427