DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vap and Rasa1

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_037267.1	Gene:	Rasa1 / 25676	RGDID:	3537	Length:	1038	Species:	Rattus norvegicus

Alignment Length:	936	Identity:	438/936 - (46%)
Similarity:	602/936 - (64%)	Gaps:	49/936 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GLGG---------IMAPGGIDLGDLAQELDHDEFDGPHMLNGERPAI--IAPPESEWYHGRLDRY 92
            |.||         ::.|.|..||.:.   :.|..|||. ...|..||  .|||.::||||:|||.
  Rat   120 GPGGGFPPLPPPPLLPPLGSGLGTVD---EGDSLDGPE-YEEEEVAIPLTAPPTNQWYHGKLDRT 180

  Fly    93 SAESRLRGSSKLGSYLVRESDRKPGSYVLSYYGRTG-INHFRITAVCGDFYIGGRQFISLSDLVG 156
            .||.|||.:.|.||||:|||||:|||:|||:..:|. :|||||.|:|||:|||||:|.|||||:|
  Rat   181 IAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIG 245

  Fly   157 YYTSCSDLLKRERLAIPVAPPEPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDGWLW 221
            ||:..|.|||.|:|..||||||||.|::||.|||||||:|:|||:||.|||:|.|||::.|||:|
  Rat   246 YYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMW 310

  Fly   222 VTAHRTGEQGMIFRELVDDLDVSIDPNTVFPWFHPNCTKNEAVDMLVKAGP-GSFLVRPSDNSPG 285
            ||..||.|||:|..:||:::....||:....|||...:|.||.::|:..|. .|||||||||:||
  Rat   311 VTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPG 375

  Fly   286 DYSLFFHINNQIQRFRI-EKKGVRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPVVNGIQPEF 349
            ||||:|..|..||||:| .....:::||||.:..:..:|:.|||||||||:.|..||     |..
  Rat   376 DYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPV-----PMQ 435

  Fly   350 NQQYVVEKAAE--KIYATL-RECRDQIGLKKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSET 411
            :|..|:....:  :||.|: |:.:|..    .|.|...|:|.||. |..:||.|||.|  :||:.
  Rat   436 DQGQVLNDTVDGKEIYNTIRRKTKDAF----YKNIVKKGYLLKKG-KGKRWKNLYFIL--EGSDA 493

  Fly   412 QLCFYDNPKK-TKPKGLIDLSCAYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVE 475
            ||.::::.|: ||||||||||...:|..||||:.||.|||||.:.......:.|....:.|...:
  Rat   494 QLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAED 558

  Fly   476 WINSLKAQCDSQLSRAQKKVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKI 540
            |:..|:|.|..:.|.......|||::..|.||:.|||:||.|...:|||:|.||.|:|.||..:.
  Rat   559 WMKGLQAFCSLRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHARE 623

  Fly   541 APEPVWEEEFVLDDVPPDVVSLTITLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTP 605
            ...|||.||||.||:|||:....|||.::.|:.||.::..:...||.|:.|..|:.|:.|:...|
  Rat   624 GQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIP 688

  Fly   606 MG--EWGSLRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKALAELCHNDRVPLATALLRVFRQ 668
            :.  |.||||:|.||..:.|||.||||..::|:|:.||:.|.||:.:|..||..||:.||::|..
  Rat   689 LKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLKIFLH 753

  Fly   669 EKRETELIRMLCQAEVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQS 733
            ||.|:.|:..|...|::.|:|.|||||..:||:|||:.||:...:.|:..|:.:::.:|:|||||
  Rat   754 EKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQS 818

  Fly   734 AELNPTKMDVNDDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVR 798
            .||:|:|::.|:|..||...||.||..:.:.||.:.:..|..:|:|..||||:|..||||...:|
  Rat   819 CELSPSKLEKNEDVNTNLAHLLSILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNNTMR 883

  Fly   799 TRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQYMEVVN 863
            |||||||:||||:|||:||||.|.::|::|...|.|:|.:|||.:||||||:|||.||.|||.||
  Rat   884 TRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVN 948

  Fly   864 PFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLHHICVSHSQELHELSN 928
            |||..||.|||:|||:|.:|  |..|      .:|..:..|..|:||.||.|||:||.||..|||
  Rat   949 PFIKSNKHRMIMFLDELGNV--PELP------DTTEHSRTDLSRDLAALHEICVAHSDELRTLSN 1005

  Fly   929 ILSI-----KKLVTVTDMLTKHKLKY 949
            ...:     |||:.:|::|.:.:.:|
  Rat  1006 ERGVQQHVLKKLLAITELLQQKQNQY 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216	63/104 (61%)
		SH3_RasGAP	183..241	CDD:212722	36/57 (63%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	35/75 (47%)
		PH_RASA1	379..484	CDD:270080	45/105 (43%)
		C2_Ras_p21A1	499..622	CDD:176045	54/124 (44%)
		RasGAP	620..954	CDD:413381	158/335 (47%)
Rasa1	NP_037267.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..152		8/34 (24%)
		SH2_Nterm_RasGAP	152..255	CDD:198216	62/103 (60%)
		SH3_RasGAP	272..330	CDD:212722	36/57 (63%)
		SH2_Cterm_RasGAP	341..417	CDD:198217	35/75 (47%)
		PH	480..568	CDD:278594	38/89 (43%)
		PH_RASA1	480..567	CDD:270080	38/88 (43%)
		C2_Ras_p21A1	582..707	CDD:176045	54/124 (44%)
		RasGAP	689..1035	CDD:214617	166/351 (47%)
		RasGAP_p120GAP	705..1036	CDD:213340	158/335 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346295
Domainoid	1	1.000	123	1.000	Domainoid score	I5470
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2168
Inparanoid	1	1.050	798	1.000	Inparanoid score	I481
OMA	1	1.010	-	-		QHG48483
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0006956
OrthoInspector	1	1.000	-	-		oto96897
orthoMCL	1	0.900	-	-		OOG6_105831
Panther	1	1.100	-	-	LDO	PTHR10194
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5047
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770