Protein Alignment vap and Rasal2

DIOPT Version :9

• Sequence 1: NP_001285314.1
• Gene: vap / 32569
• FlyBaseID: FBgn0003969
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: XP_006496813.1
• Gene: Rasal2 / 226525
• MGIID: 2443881
• Length: 1289
• Species: Mus musculus
• Alignment Length: 587
• Identity: 146/587 - (24%)
• Similarity: 256/587 - (43%)
• Gaps: 113/587 - (19%)

  Fly   365 TLRECRDQI-GLKKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCF---YDNPKKTKPK 425
            :||...|:. ||.|:|..:.|.                 :|::..|..: |.   ...|...||
Mouse   217 SLRNADDRSRGLPKLKESRSHE-----------------SLLSPCSAVE-CLDLGRGEPVSVKP- 262

  Fly   426 GLIDLSCAYLYQCHDSLWERPYCFQIVERALPCLATVTYL-------CAPSQESYVEWINSLKAQ 483
                        .|.|:..:.:||:           ||||       |:.:.|. .:|:.:|:..
Mouse   263 ------------LHSSILGQDFCFE-----------VTYLSGSKCFSCSSASER-DKWMENLRRT 303

  Fly   484 CDSQLSRAQKKVSRLRELRCLNLHVLEAHRL-PFKLVPHPYCSISLNQVKVGKTRVKIAPEPV-W 546
            ........::..:.||      |.::||..| |.|..   :|.:.|:.....:|..|...:.: |
Mouse   304 VQPNKDNCRRAENVLR------LWIIEAKDLAPKKKY---FCELCLDDTLFARTTSKTKADNIFW 359

  Fly   547 EEEFVLDDVPPDVVSLTITLI----SRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTP-M 606
            .|.|....:|| :.|:|:.:.    .:.|:.|::.|..:.|..:|:...|..|.||.::..|| .
Mouse   360 GEHFEFYSLPP-LHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNK 423

  Fly   607 GEWG--SLRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKALAELCH-NDRVPLATALLRVFRQ 668
            |:.|  |:|::.|:....|:|.|:|....:.:..:.......|..:.. .::..||.||:.:.:.
Mouse   424 GKTGGPSIRIKSRFQTITILPMEQYKEFAEFITSNYTMLCSVLEPVISVRNKEELACALVHILQS 488

  Fly   669 EKRETELIRMLCQAEVTRENETTTL-FRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQ 732
            ..|..:.:..|..:||.|..|...| ||..::||..::.|::.....:|..|:.|.::.:.||.:
Mouse   489 TGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDE 553

  Fly   733 SAELNPTKMDVNDDACTNAEF------LLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKW 791
            :.|::|:|       |:::|.      |....:|....|..|....||.:        |.|.|.|
Mouse   554 NCEVDPSK-------CSSSELMDHQSNLKMCCELAFCKIINSYCVFPREL--------KEVFASW 603

  Fly   792 PTERL------VRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLI 850
            ..:.|      :..|::|..:|||.||||:::|..|.|:.|.|....:|:|.::||.:|||||..
Mouse   604 KQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFA 668

  Fly   851 EFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGM--FVEQSTNLNSQDTGRELATLH 913
            :||.||:||..:|.|:......|..||.::|:.:..:...|.  ::         |.||||:.||
Mouse   669 KFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYI---------DLGRELSVLH 724

  Fly   914 HI 915
            .:
Mouse   725 SL 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722
		SH2_Cterm_RasGAP	252..326	CDD:198217
		PH_RASA1	379..484	CDD:270080	20/114 (18%)
		C2_Ras_p21A1	499..622	CDD:176045	34/131 (26%)
		RasGAP	620..954	CDD:413381	85/312 (27%)
Rasal2	XP_006496813.1	PH-like	181..364	CDD:388408	40/198 (20%)
		C2_SynGAP_like	306..445	CDD:175980	36/148 (24%)
		RasGAP_DAB2IP	436..766	CDD:213338	86/315 (27%)
		DUF3498	756..1232	CDD:371844

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810