Protein Alignment vap and Rasa1

DIOPT Version :10

• Sequence 1: NP_523361.1
• Gene: vap / 32569
• FlyBaseID: FBgn0003969
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: NP_663427.2
• Gene: Rasa1 / 218397
• MGIID: 97860
• Length: 1038
• Species: Mus musculus
• Alignment Length: 922
• Identity: 435/922 - (47%)
• Similarity: 598/922 - (64%)
• Gaps: 40/922 - (4%)

  Fly    44 MAPGGIDLGDLAQELDHDEFDGPHMLNGERPAI--IAPPESEWYHGRLDRYSAESRLRGSSKLGS 106
            :.|.|..||.:.   :.|..|||. ...|..||  .|||.::||||:|||..||.|||.:.|.||
Mouse   134 LPPLGSGLGTVD---EGDSLDGPE-YEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGS 194

  Fly   107 YLVRESDRKPGSYVLSYYGRTG-INHFRITAVCGDFYIGGRQFISLSDLVGYYTSCSDLLKRERL 170
            ||:|||||:|||:|||:..:|. :|||||.|:|||:|||||:|.|||||:|||:..|.|||.|:|
Mouse   195 YLIRESDRRPGSFVLSFLSQTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKL 259

  Fly   171 AIPVAPPEPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMIFR 235
            ..||||||||.|::||.|||||||:|:|||:||.|||:|.|||::.|||:|||..||.|||:|..
Mouse   260 LYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVE 324

  Fly   236 ELVDDLDVSIDPNTVFPWFHPNCTKNEAVDMLVKAGP-GSFLVRPSDNSPGDYSLFFHINNQIQR 299
            :||:::....||:....|||...:|.||.::|:..|. .|||||||||:||||||:|..|..|||
Mouse   325 DLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQR 389

  Fly   300 FRI-EKKGVRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPVVNGIQPEFNQQYVVEKAAE--K 361
            |:| .....:::||||.:..:..:|:.|||||||||:.|..||     |..:|..|:....:  :
Mouse   390 FKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPV-----PMQDQGQVLNDTVDGKE 449

  Fly   362 IYATL-RECRDQIGLKKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCFYDNPKK-TKP 424
            ||.|: |:.:|..    .|.|...|:|.||. |..:||.|||.|  :||:.||.::::.|: |||
Mouse   450 IYNTIRRKTKDAF----YKNIVKKGYLLKKG-KGKRWKNLYFIL--EGSDAQLIYFESEKRATKP 507

  Fly   425 KGLIDLSCAYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLS 489
            |||||||...:|..||||:.||.|||||.:.......:.|....:.|...:|:..|:|.|..:.|
Mouse   508 KGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCSLRKS 572

  Fly   490 RAQKKVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPVWEEEFVLDD 554
            .......|||::..|.||:.|||:||.|...:|||:|.||.|:|.||..:....|||.||||.||
Mouse   573 SPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDD 637

  Fly   555 VPPDVVSLTITLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMG--EWGSLRLRMR 617
            :|||:....|||.::.|:.||.::..:...||.|:.|..|:.|:.|:...|:.  |.||||:|.|
Mouse   638 LPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRAR 702

  Fly   618 YLDDLIMPCEEYSPLQQLLLESELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRMLCQA 682
            |..:.|||.||||..::|:|:.||:.|.||:.:|..||..||:.||::|..||.|:.|:..|...
Mouse   703 YSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLKIFLHEKLESLLLCTLNDR 767

  Fly   683 EVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDA 747
            |::.|:|.|||||..:||:|||:.||:...:.|:..|:.:::.:|:|||||.||:|:|::.|:|.
Mouse   768 EISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDV 832

  Fly   748 CTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVRTRVVSGFIFLRLLC 812
            .||...||.||..:.:.||.:.:..|..:|:|..||||:|..||||...:||||||||:||||:|
Mouse   833 NTNLAHLLSILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNNTMRTRVVSGFVFLRLIC 897

  Fly   813 PALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQYMEVVNPFILKNKERMIVFL 877
            ||:||||.|.::|::|...|.|:|.:|||.:||||||:|||.||.|||.|||||..||.|||:||
Mouse   898 PAILNPRMFNIISDSPSPIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFL 962

  Fly   878 DQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLHHICVSHSQELHELSNILSI-----KKLVT 937
            |:|.:|  |..|      .:|..:..|..|:||.||.|||:||.||..|||...:     |||:.
Mouse   963 DELGNV--PELP------DTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGVQQHVLKKLLA 1019

  Fly   938 VTDMLTKHKLKY 949
            :|::|.:.:.:|
Mouse  1020 ITELLQQKQNQY 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_523361.1	SH2_Nterm_RasGAP	64..166	CDD:198216	63/104 (61%)
		SH3_RasGAP	183..241	CDD:212722	36/57 (63%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	35/75 (47%)
		PH_RASA1	379..484	CDD:270080	45/105 (43%)
		C2_Ras_p21A1	499..622	CDD:176045	54/124 (44%)
		RasGAP	620..954	CDD:470620	158/335 (47%)
Rasa1	NP_663427.2	SH2_Nterm_RasGAP	152..255	CDD:198216	62/103 (60%)
		SH3_RasGAP	272..330	CDD:212722	36/57 (63%)
		SH2_Cterm_RasGAP	341..417	CDD:198217	35/75 (47%)
		PH_RASA1	480..567	CDD:270080	38/88 (43%)
		C2_Ras_p21A1	582..707	CDD:176045	54/124 (44%)
		RasGAP_p120GAP	705..1036	CDD:213340	158/335 (47%)