DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vap and Rasa1

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_663427.2	Gene:	Rasa1 / 218397	MGIID:	97860	Length:	1038	Species:	Mus musculus

Alignment Length:	922	Identity:	435/922 - (47%)
Similarity:	598/922 - (64%)	Gaps:	40/922 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 MAPGGIDLGDLAQELDHDEFDGPHMLNGERPAI--IAPPESEWYHGRLDRYSAESRLRGSSKLGS 106
            :.|.|..||.:.   :.|..|||. ...|..||  .|||.::||||:|||..||.|||.:.|.||
Mouse   134 LPPLGSGLGTVD---EGDSLDGPE-YEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGKSGS 194

  Fly   107 YLVRESDRKPGSYVLSYYGRTG-INHFRITAVCGDFYIGGRQFISLSDLVGYYTSCSDLLKRERL 170
            ||:|||||:|||:|||:..:|. :|||||.|:|||:|||||:|.|||||:|||:..|.|||.|:|
Mouse   195 YLIRESDRRPGSFVLSFLSQTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKL 259

  Fly   171 AIPVAPPEPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMIFR 235
            ..||||||||.|::||.|||||||:|:|||:||.|||:|.|||::.|||:|||..||.|||:|..
Mouse   260 LYPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVE 324

  Fly   236 ELVDDLDVSIDPNTVFPWFHPNCTKNEAVDMLVKAGP-GSFLVRPSDNSPGDYSLFFHINNQIQR 299
            :||:::....||:....|||...:|.||.::|:..|. .|||||||||:||||||:|..|..|||
Mouse   325 DLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQR 389

  Fly   300 FRI-EKKGVRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPVVNGIQPEFNQQYVVEKAAE--K 361
            |:| .....:::||||.:..:..:|:.|||||||||:.|..||     |..:|..|:....:  :
Mouse   390 FKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPV-----PMQDQGQVLNDTVDGKE 449

  Fly   362 IYATL-RECRDQIGLKKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCFYDNPKK-TKP 424
            ||.|: |:.:|..    .|.|...|:|.||. |..:||.|||.|  :||:.||.::::.|: |||
Mouse   450 IYNTIRRKTKDAF----YKNIVKKGYLLKKG-KGKRWKNLYFIL--EGSDAQLIYFESEKRATKP 507

  Fly   425 KGLIDLSCAYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLS 489
            |||||||...:|..||||:.||.|||||.:.......:.|....:.|...:|:..|:|.|..:.|
Mouse   508 KGLIDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCSLRKS 572

  Fly   490 RAQKKVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPVWEEEFVLDD 554
            .......|||::..|.||:.|||:||.|...:|||:|.||.|:|.||..:....|||.||||.||
Mouse   573 SPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDD 637

  Fly   555 VPPDVVSLTITLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMG--EWGSLRLRMR 617
            :|||:....|||.::.|:.||.::..:...||.|:.|..|:.|:.|:...|:.  |.||||:|.|
Mouse   638 LPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRAR 702

  Fly   618 YLDDLIMPCEEYSPLQQLLLESELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRMLCQA 682
            |..:.|||.||||..::|:|:.||:.|.||:.:|..||..||:.||::|..||.|:.|:..|...
Mouse   703 YSMEKIMPEEEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLKIFLHEKLESLLLCTLNDR 767

  Fly   683 EVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDA 747
            |::.|:|.|||||..:||:|||:.||:...:.|:..|:.:::.:|:|||||.||:|:|::.|:|.
Mouse   768 EISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDV 832

  Fly   748 CTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVRTRVVSGFIFLRLLC 812
            .||...||.||..:.:.||.:.:..|..:|:|..||||:|..||||...:||||||||:||||:|
Mouse   833 NTNLAHLLSILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNNTMRTRVVSGFVFLRLIC 897

  Fly   813 PALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQYMEVVNPFILKNKERMIVFL 877
            ||:||||.|.::|::|...|.|:|.:|||.:||||||:|||.||.|||.|||||..||.|||:||
Mouse   898 PAILNPRMFNIISDSPSPIAARTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFL 962

  Fly   878 DQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLHHICVSHSQELHELSNILSI-----KKLVT 937
            |:|.:|  |..|      .:|..:..|..|:||.||.|||:||.||..|||...:     |||:.
Mouse   963 DELGNV--PELP------DTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGVQQHVLKKLLA 1019

  Fly   938 VTDMLTKHKLKY 949
            :|::|.:.:.:|
Mouse  1020 ITELLQQKQNQY 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216	63/104 (61%)
		SH3_RasGAP	183..241	CDD:212722	36/57 (63%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	35/75 (47%)
		PH_RASA1	379..484	CDD:270080	45/105 (43%)
		C2_Ras_p21A1	499..622	CDD:176045	54/124 (44%)
		RasGAP	620..954	CDD:413381	158/335 (47%)
Rasa1	NP_663427.2	SH2_Nterm_RasGAP	152..255	CDD:198216	62/103 (60%)
		SH3_RasGAP	272..330	CDD:212722	36/57 (63%)
		SH2_Cterm_RasGAP	341..417	CDD:198217	35/75 (47%)
		PH	480..568	CDD:278594	38/89 (43%)
		PH_RASA1	480..567	CDD:270080	38/88 (43%)
		C2_Ras_p21A1	582..707	CDD:176045	54/124 (44%)
		RasGAP	689..1035	CDD:214617	166/351 (47%)
		RasGAP_p120GAP	705..1036	CDD:213340	158/335 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842826
Domainoid	1	1.000	123	1.000	Domainoid score	I5583
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2168
Inparanoid	1	1.050	794	1.000	Inparanoid score	I505
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48483
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0006956
OrthoInspector	1	1.000	-	-		oto93354
orthoMCL	1	0.900	-	-		OOG6_105831
Panther	1	1.100	-	-	LDO	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5207
SonicParanoid	1	1.000	-	-		X5047
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800