DRSC/TRiP Functional Genomics Resources

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Protein Alignment vap and Rasa3

DIOPT Version :10

Sequence 1:NP_523361.1 Gene:vap / 32569 FlyBaseID:FBgn0003969 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_033051.2 Gene:Rasa3 / 19414 MGIID:1197013 Length:834 Species:Mus musculus


Alignment Length:542 Identity:149/542 - (27%)
Similarity:228/542 - (42%) Gaps:99/542 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   476 WINSLKAQCDSQLSRAQKKVS---RLREL--------RCLNLHVLEAHRLPFKLVP---HPYCSI 526
            |........||::   |.||.   ||.|:        ..|...:.|...||  :|.   .||.::
Mouse   111 WFQLQHVDADSEV---QGKVHLELRLSEVITDTGVVCHKLAARIFECQGLP--IVNGQCDPYATV 170

  Fly   527 SL-----NQVKVGKTRV-KIAPEPVWEEEFVLDDVPP--------------DVVSLTITL----I 567
            :|     ::.|  ||:| |....|.::|.|..:...|              ||..|.|.:    .
Mouse   171 TLAGPFRSEAK--KTKVKKKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNA 233

  Fly   568 SRGKRGKDSEVAELTIDLSSLKNGQETEGWYQL-------TGMTPMGEWGSLRLRMRYLDDLIMP 625
            |..|.| |..:.||.:.|..|::....|.||.|       ..:.| .:.|||||.:.|.:|.:..
Mouse   234 SNLKFG-DEFLGELRLPLKILRHSSSYEAWYFLQPRDNGNKSLKP-DDLGSLRLNVVYTEDHVFS 296

  Fly   626 CEEYSPLQQLLLES------ELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRMLCQAEV 684
            .|.||||:.|||:|      ...|...|.|:| .|:...|..|:|:.....|....|..:..|||
Mouse   297 SEYYSPLRDLLLKSADVEPVSASAAHILGEVC-RDKQEAAIPLVRLLLHYGRVVPFISAIASAEV 360

  Fly   685 TRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDACT 749
            .|..:..|:|||.||.:..:|..|:.....:|...:..|::.|.:|.:|.|::|.|:...::...
Mouse   361 KRTQDPNTIFRGNSLTSKCIDETMKLAGMHYLHVTLKPTIEEICQSHKSCEIDPVKLKDGENLEN 425

  Fly   750 NAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVRTRVVSGFIFLRLLCPA 814
            |.|.|.|.:|.:...|..|..:||..:..|...|::|...::..:..||...||.|||||...||
Mouse   426 NMESLRQYVDRIFTVITKSGVSCPTVMCDIFFSLREAAAKRFQDDLDVRYTAVSSFIFLRFFAPA 490

  Fly   815 LLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGG---KEQYMEVVNPFILKNKERMIV- 875
            :|:|..|.|.........:|:|.:::|.:|.|.:|.:...   ||.||.....|..:.|....| 
Mouse   491 ILSPNLFQLTPHHTDPQTSRTLTLISKTIQTLGSLSKSKSASFKESYMATFYEFFNEQKYADAVK 555

  Fly   876 -FLDQLSSV--NDP---NQPL----GMFVEQSTNLNSQDTGRE------------LATLHHICVS 918
             |||.:||.  .||   .||:    |..::::       .||:            ..|.|.....
Mouse   556 NFLDLISSSGRRDPKSIEQPILLKEGFMIKRA-------QGRKRFGMKNFKKRWFRLTNHEFTYQ 613

  Fly   919 HSQELHEL-----SNILSIKKL 935
            .|:....|     .|||::::|
Mouse   614 KSKGDQPLCNIPIENILAVERL 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vapNP_523361.1 SH2_Nterm_RasGAP 64..166 CDD:198216
SH3_RasGAP 183..241 CDD:212722
SH2_Cterm_RasGAP 252..326 CDD:198217
PH_RASA1 379..484 CDD:270080 1/7 (14%)
C2_Ras_p21A1 499..622 CDD:176045 41/164 (25%)
RasGAP 620..954 CDD:470620 100/353 (28%)
Rasa3NP_033051.2 C2A_RasA2_RasA3 13..133 CDD:176046 6/24 (25%)
C2B_RasA3 146..288 CDD:175977 39/147 (27%)
RasGAP_RASA3 297..565 CDD:213336 84/268 (31%)
PH_GAP1_mammal-like 562..686 CDD:241522 17/81 (21%)
BTK 679..714 CDD:128417
Blue background indicates that the domain is not in the aligned region.

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