DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment vap and Syngap1

DIOPT Version :9

Sequence 1:NP_001285314.1 Gene:vap / 32569 FlyBaseID:FBgn0003969 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_851606.3 Gene:Syngap1 / 192117 RGDID:621090 Length:1308 Species:Rattus norvegicus


Alignment Length:658 Identity:163/658 - (24%)
Similarity:272/658 - (41%) Gaps:145/658 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   334 GHSLNHPVVNGIQPEFNQQYVVEKAAEKIYATLRECRDQIGLKKIKGIKHHGHLNKKSDKTTKWK 398
            |.|....|..|      :||.:|.|..   |..|..:..:. :::|..........|.|:|:.::
  Rat   103 GRSRRKSVPGG------KQYSMEAAPA---APFRPSQGFLS-RRLKSSIKRTKSQPKLDRTSSFR 157

  Fly   399 QL---YFALINDGSETQLCFYDNPKKTKPKGLIDLSCA------------YLYQCHDSLWERPYC 448
            |:   :.:..:|.:.....|.::...   :.|:..|.|            .:...|.|:..:.:|
  Rat   158 QILPRFRSADHDRARLMQSFKESHSH---ESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFC 219

  Fly   449 FQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQK--KVSRLRELRCLNLHVLEA 511
            |::...:    .|..:.|..:.|. .:||.:|:        ||.|  |.:..|....|.|.::||
  Rat   220 FEVTTSS----GTKCFACRSAAER-DKWIENLQ--------RAVKPNKDNSRRVDNVLKLWIIEA 271

  Fly   512 HRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPV------WEEEFVLDDVPPDVVSLTITLI--S 568
            ..||.|  ...||.:.|:.:...:|..|  |...      |.|.|..:::|. |.:|.:.|.  |
  Rat   272 RELPPK--KRYYCELCLDDMLYARTTSK--PRSASGDTVFWGEHFEFNNLPA-VRALRLHLYRDS 331

  Fly   569 RGKRGKDSE--VAELTIDLSSLKNGQETEGWYQLT------GMTPMGEWG--------------- 610
            ..||.||..  |..:|:.:::|.....||.||.:|      |...||..|               
  Rat   332 DKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGG 396

  Fly   611 --SLRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKALAELCH--------NDRVPLATALLRV 665
              ::||:.||....|:|.|.|....:       |.......||.        ..:..:|:||:.:
  Rat   397 CPAVRLKARYQTMSILPMELYKEFAE-------YVTNHYRMLCAVLEPALNVKGKEEVASALVHI 454

  Fly   666 FRQEKRETELIRMLCQAEVTRENETTTL-FRGASLATTLMDLYMRTECSGFLQSAVSETVQRILE 729
            .:...:..:.:..:..:||.|..|...| ||..:|||..::.|||.....:|:.|:.|.::.:.|
  Rat   455 LQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYE 519

  Fly   730 SKQSAELNPTKMDVNDDACTNAEF------LLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVM 788
            |:::.|::|.|       ||.:..      |....:|....:..|....|..:        |.|.
  Rat   520 SEENCEVDPIK-------CTASSLAEHQANLRMCCELALCKVVNSHCVFPGEL--------KEVF 569

  Fly   789 AKWPTERL---------VRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQ 844
            |.|   ||         :..|::|..:|||.||||:::|..|||:.|.|....:|:|.::||.:|
  Rat   570 ASW---RLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQ 631

  Fly   845 NLANLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNS----QDT 905
            ||||..:|..||.::..:|.|:......|..||.::|:           ::..||.:|    .|.
  Rat   632 NLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISN-----------LDTLTNSSSFEGYIDL 685

  Fly   906 GRELATLH 913
            ||||:|||
  Rat   686 GRELSTLH 693

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vapNP_001285314.1 SH2_Nterm_RasGAP 64..166 CDD:198216
SH3_RasGAP 183..241 CDD:212722
SH2_Cterm_RasGAP 252..326 CDD:198217
PH_RASA1 379..484 CDD:270080 20/119 (17%)
C2_Ras_p21A1 499..622 CDD:176045 42/155 (27%)
RasGAP 620..954 CDD:413381 87/322 (27%)
Syngap1NP_851606.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 92..113 3/9 (33%)
PH_SynGAP 122..313 CDD:270178 42/214 (20%)
PH <188..251 CDD:278594 14/75 (19%)
C2_SynGAP_like 252..414 CDD:175980 44/166 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 373..394 4/20 (20%)
RasGAP 401..720 CDD:214617 91/329 (28%)
RasGAP_DAB2IP 405..728 CDD:213338 89/325 (27%)
DUF3498 718..1295 CDD:288827
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 725..751
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 781..809
SH3-binding. /evidence=ECO:0000255 785..815
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 932..1017
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1033..1153
Rho_Binding 1196..1255 CDD:286056
Interaction with MPDZ. /evidence=ECO:0000269|PubMed:15312654 1197..1308
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1276..1308
PDZ-binding. /evidence=ECO:0000255 1305..1308
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3508
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D44624at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.