DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment vap and RASA4

DIOPT Version :10

Sequence 1:NP_523361.1 Gene:vap / 32569 FlyBaseID:FBgn0003969 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_008920.5 Gene:RASA4 / 10156 HGNCID:23181 Length:803 Species:Homo sapiens


Alignment Length:577 Identity:144/577 - (24%)
Similarity:241/577 - (41%) Gaps:109/577 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   396 KWKQLYFALIN---------DGSETQLCF--YDNPKKTKPKGLIDLSCAYL---YQCHDSLWERP 446
            |...||..::.         .||....|.  .||....:...:....|.:.   ||.|     .|
Human     3 KRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVH-----LP 62

  Fly   447 YCFQIV------ERALP--------CLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQKKV-- 495
            ..|..|      |.||.        ||...|....|  :.:..|.:..:...|.::   |.::  
Human    63 PTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHP--KGFSGWAHLTEVDPDEEV---QGEIHL 122

  Fly   496 -------SRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKV---GKTR----VKIAPEPVW 546
                   :|...|||   .||||.    .|.|......|...|:|   |:||    ||.:..|.|
Human   123 RLEVWPGARACRLRC---SVLEAR----DLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRW 180

  Fly   547 EE--EFVLDDVPPDVVSLTI---TLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQL------ 600
            .|  ||.|.:...:.:.:..   .|:||     :..:.::.||:..|:..|:.|||::|      
Human   181 NETFEFELQEGAMEALCVEAWDWDLVSR-----NDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSK 240

  Fly   601 TGMTPMGEWGSLRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKALAEL-----------CHND 654
            :.....|..|||:|.:|..|:.::|...|.||..||.......::...:|           |..|
Human   241 SRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD 305

  Fly   655 RVPLATALLRVFRQEKRETELIRMLCQAEVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSA 719
               :||.||::|..:....:.:.:|.|.|::|.:||.||||..|||:..|:.:::.....:|...
Human   306 ---VATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGV 367

  Fly   720 VSETVQRILESKQSAELNPTKMDVNDDAC-------TNAEFLLQI-------LDLVTQSIFTSPD 770
            :...:.::.|.|:..||:|:|::|.|..|       |.||.|.|.       |..:..::..|..
Human   368 LGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVR 432

  Fly   771 ACPRNVRFICSCLQKAVMAKWP--TERLVRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAAT 833
            |||..||.....|.:.|..::|  ....|....|:.|:.||...||:::|:.|.|.........:
Human   433 ACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTS 497

  Fly   834 RSLVMVAKCLQNLANL--IEFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQ 888
            |:|:::||.:||:.|:  .....||.:||.:.|.:.:...::..|:.:|..:.:.::
Human   498 RTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEKDE 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vapNP_523361.1 SH2_Nterm_RasGAP 64..166 CDD:198216
SH3_RasGAP 183..241 CDD:212722
SH2_Cterm_RasGAP 252..326 CDD:198217
PH_RASA1 379..484 CDD:270080 23/115 (20%)
C2_Ras_p21A1 499..622 CDD:176045 41/140 (29%)
RasGAP 620..954 CDD:470620 78/298 (26%)
RASA4NP_008920.5 C2A_Rasal1_RasA4 6..126 CDD:176018 24/129 (19%)
C2B_RasA1_RasA4 134..257 CDD:175991 39/134 (29%)
RasGAP_RASA4 265..550 CDD:213343 77/287 (27%)
PH_CAPRI 542..681 CDD:241523 2/13 (15%)
BTK 681..710 CDD:459937
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 781..803
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.