Protein Alignment vap and rasal3

DIOPT Version :10

• Sequence 1: NP_523361.1
• Gene: vap / 32569
• FlyBaseID: FBgn0003969
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: XP_002935455.2
• Gene: rasal3 / 100488943
• XenbaseID: XB-GENE-6048180
• Length: 1009
• Species: Xenopus tropicalis
• Alignment Length: 857
• Identity: 207/857 - (24%)
• Similarity: 340/857 - (39%)
• Gaps: 206/857 - (24%)

  Fly   174 VAPPEPVNDKKRVVAILPYTKMPETDEL-SFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMIFREL 237
            |.|.|...|     :::..:.:|||.:| |:|                |.|||  |::|.::..|
 Frog     2 VEPCEDAGD-----SVVQDSNLPETSDLGSYQ----------------WNTAH--GQKGGVWGRL 43

  Fly   238 VDDLDVSIDPNTVFPWFH--------PNCTKNEAVDMLVKAGPG--------SFL---------- 276
            ..             |.|        ...:|.:...:..|..|.        .:|
 Frog    44 QG-------------WRHTLMLQAKETQGSKKKHRSLFRKKSPSEPPSRGLTKYLHSVSQRLGRK 95

  Fly   277 --VRPS-DNSPG----------------DYSLFFHINNQIQRFRIEKKGVRYLMGGRTFECLDAV 322
              :||| |...|                |.|.|..|:..:...:.:::|..::. .||..|
 Frog    96 KDIRPSLDGIEGPVPLPVPVSAPEIPVWDISNFSLIDGCLLLTKGDEQGACHIR-SRTGSC---- 155

  Fly   323 INRYRKEQIVEGHSLNHPVV--NGIQPEFNQQYVVEKAAEKIYATLRECRDQIGLKKIKGIKHHG 385
            :::...||..:...:..|.|  ..:.|:...|:                      ..:||:
 Frog   156 VSKSLTEQTDQTDGVVDPPVPEGNVDPDTKNQF----------------------NNVKGL---- 194

  Fly   386 HLNKKSDKTTKWKQLYFALIND-----GSETQLCFYD-----NPKKTKPKGLIDLSCAYLYQCHD 440
             :.|:..|.|:.|....:|..:     ||...|...:     |.|....|.|           |.
 Frog   195 -IQKRKKKKTRKKGSASSLQQEERSLHGSRESLGGVEILDLVNEKDVTIKAL-----------HS 247

  Fly   441 SLWERPYCFQIV-ERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQKKVSRLRELRCL 504
            |:....|||:|: ..:..|.|     |:..||. ..||.:|:..........:::.|      .|
 Frog   248 SILGERYCFEIITAESSRCFA-----CSSLQER-DRWIENLRRIVQPDKDNFERQES------SL 300

  Fly   505 NLHVLEAHRLPFKLVPHP------YCSISLNQVKVGKTRVKIAPEP---VWEEEFVLDDVPPDVV 560
            :|.:.||..||   |..|      :|.:.|:....|:|..| |||.   .|.|.|.|.|:.....
 Frog   301 SLWIHEAKGLP---VSGPGSRSCYFCEVQLDGCLYGRTSSK-APEAGVVFWGESFNLRDLSSVQG 361

  Fly   561 SLTITLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEWGSLRLRMRYLDDLIMP 625
            .:.:.|:..||  :.:.|..:|:.|..:|:|  .|.|      .|:|...:||:|.||....::|
 Frog   362 HMALHLLQEGK--ETTGVGTVTLALEGMKDG--AEKW------VPLGGEMALRVRGRYRKLSVLP 416

  Fly   626 CEEYSPLQQLLLESELYAVKALAE-LCHNDRVPLATALLRVFRQEKRETELIRMLCQAEVTR-EN 688
            ..:|....:.|....:...:|:.. |...::..|..:|:.|.:...:..|.:..|..||::| :.
 Frog   417 VMQYKEFAEYLTWRYMELSRAMEPILSAREKEELGRSLVYVLQSTGKAKEFLVDLGVAEISRHDG 481

  Fly   689 ETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDACTNAEF 753
            :.:.:||..::.|..::.||:.....:||..:...|.||..|:.|.|::|.:.. .:|...|...
 Frog   482 QDSLIFRENTIVTKAIEEYMKMVGQTYLQETLGPFVNRIYTSEDSHEVDPLRCS-PEDLGENRGQ 545

  Fly   754 LLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVR------TRVVSGFIFLRLLC 812
            |.:..:...|||..|.::.|.::        ..:.:.|..|..:|      :|:||..:|||.||
 Frog   546 LWRSCEDAVQSILQSQESFPPDL--------LEIFSSWQVEVALRGRPALGSRLVSASLFLRFLC 602

  Fly   813 PALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQYMEVVNPFILKNKERMIVFL 877
            ||:|:|..|.|.:|.|...|.|:|.:|||.||||||...||.||:||..:|.|:.:..:.|.||
 Frog   603 PAILSPGLFNLSAEHPQPLAARALTLVAKVLQNLANFTRFGEKEEYMGFMNGFLEQYGDGMSVF- 666

  Fly   878 DQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLHHICVS-----HSQELHELSNILSIKKLVT 937
              |.:|.||...    |..:...:|.|...|||.||.:...     |.|...:|..:.:|.|.:|
 Frog   667 --LQAVADPESE----VSPTRYESSADLAYELAVLHSMLSGIFTGVHQQTKDQLEPLPTILKALT 725

  Fly   938 ----VTDMLTKH 945
                |...:|:|
 Frog   726 EGQPVPASITEH 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_523361.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722	13/58 (22%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	19/118 (16%)
		PH_RASA1	379..484	CDD:270080	28/115 (24%)
		C2_Ras_p21A1	499..622	CDD:176045	38/131 (29%)
		RasGAP	620..954	CDD:470620	98/343 (29%)
rasal3	XP_002935455.2	PH-like	172..311	CDD:473070	37/188 (20%)
		C2	288..417	CDD:472691	39/148 (26%)
		RasGAP_DAB2IP	408..731	CDD:213338	97/338 (29%)