DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vap and rasal3

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_002935455.2	Gene:	rasal3 / 100488943	XenbaseID:	XB-GENE-6048180	Length:	1009	Species:	Xenopus tropicalis

Alignment Length:	857	Identity:	207/857 - (24%)
Similarity:	340/857 - (39%)	Gaps:	206/857 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 VAPPEPVNDKKRVVAILPYTKMPETDEL-SFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMIFREL 237
            |.|.|...|     :::..:.:|||.:| |:|                |.|||  |::|.::..|
Frog     2 VEPCEDAGD-----SVVQDSNLPETSDLGSYQ----------------WNTAH--GQKGGVWGRL 43

  Fly   238 VDDLDVSIDPNTVFPWFH--------PNCTKNEAVDMLVKAGPG--------SFL---------- 276
            ..             |.|        ...:|.:...:..|..|.        .:|
Frog    44 QG-------------WRHTLMLQAKETQGSKKKHRSLFRKKSPSEPPSRGLTKYLHSVSQRLGRK 95

  Fly   277 --VRPS-DNSPG----------------DYSLFFHINNQIQRFRIEKKGVRYLMGGRTFECLDAV 322
              :||| |...|                |.|.|..|:..:...:.:::|..::. .||..|
Frog    96 KDIRPSLDGIEGPVPLPVPVSAPEIPVWDISNFSLIDGCLLLTKGDEQGACHIR-SRTGSC---- 155

  Fly   323 INRYRKEQIVEGHSLNHPVV--NGIQPEFNQQYVVEKAAEKIYATLRECRDQIGLKKIKGIKHHG 385
            :::...||..:...:..|.|  ..:.|:...|:                      ..:||:
Frog   156 VSKSLTEQTDQTDGVVDPPVPEGNVDPDTKNQF----------------------NNVKGL---- 194

  Fly   386 HLNKKSDKTTKWKQLYFALIND-----GSETQLCFYD-----NPKKTKPKGLIDLSCAYLYQCHD 440
             :.|:..|.|:.|....:|..:     ||...|...:     |.|....|.|           |.
Frog   195 -IQKRKKKKTRKKGSASSLQQEERSLHGSRESLGGVEILDLVNEKDVTIKAL-----------HS 247

  Fly   441 SLWERPYCFQIV-ERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQKKVSRLRELRCL 504
            |:....|||:|: ..:..|.|     |:..||. ..||.:|:..........:::.|      .|
Frog   248 SILGERYCFEIITAESSRCFA-----CSSLQER-DRWIENLRRIVQPDKDNFERQES------SL 300

  Fly   505 NLHVLEAHRLPFKLVPHP------YCSISLNQVKVGKTRVKIAPEP---VWEEEFVLDDVPPDVV 560
            :|.:.||..||   |..|      :|.:.|:....|:|..| |||.   .|.|.|.|.|:.....
Frog   301 SLWIHEAKGLP---VSGPGSRSCYFCEVQLDGCLYGRTSSK-APEAGVVFWGESFNLRDLSSVQG 361

  Fly   561 SLTITLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEWGSLRLRMRYLDDLIMP 625
            .:.:.|:..||  :.:.|..:|:.|..:|:|  .|.|      .|:|...:||:|.||....::|
Frog   362 HMALHLLQEGK--ETTGVGTVTLALEGMKDG--AEKW------VPLGGEMALRVRGRYRKLSVLP 416

  Fly   626 CEEYSPLQQLLLESELYAVKALAE-LCHNDRVPLATALLRVFRQEKRETELIRMLCQAEVTR-EN 688
            ..:|....:.|....:...:|:.. |...::..|..:|:.|.:...:..|.:..|..||::| :.
Frog   417 VMQYKEFAEYLTWRYMELSRAMEPILSAREKEELGRSLVYVLQSTGKAKEFLVDLGVAEISRHDG 481

  Fly   689 ETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDACTNAEF 753
            :.:.:||..::.|..::.||:.....:||..:...|.||..|:.|.|::|.:.. .:|...|...
Frog   482 QDSLIFRENTIVTKAIEEYMKMVGQTYLQETLGPFVNRIYTSEDSHEVDPLRCS-PEDLGENRGQ 545

  Fly   754 LLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVR------TRVVSGFIFLRLLC 812
            |.:..:...|||..|.::.|.::        ..:.:.|..|..:|      :|:||..:|||.||
Frog   546 LWRSCEDAVQSILQSQESFPPDL--------LEIFSSWQVEVALRGRPALGSRLVSASLFLRFLC 602

  Fly   813 PALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQYMEVVNPFILKNKERMIVFL 877
            ||:|:|..|.|.:|.|...|.|:|.:|||.||||||...||.||:||..:|.|:.:..:.|.||
Frog   603 PAILSPGLFNLSAEHPQPLAARALTLVAKVLQNLANFTRFGEKEEYMGFMNGFLEQYGDGMSVF- 666

  Fly   878 DQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLHHICVS-----HSQELHELSNILSIKKLVT 937
              |.:|.||...    |..:...:|.|...|||.||.:...     |.|...:|..:.:|.|.:|
Frog   667 --LQAVADPESE----VSPTRYESSADLAYELAVLHSMLSGIFTGVHQQTKDQLEPLPTILKALT 725

  Fly   938 ----VTDMLTKH 945
                |...:|:|
Frog   726 EGQPVPASITEH 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722	13/58 (22%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	19/118 (16%)
		PH_RASA1	379..484	CDD:270080	28/115 (24%)
		C2_Ras_p21A1	499..622	CDD:176045	38/131 (29%)
		RasGAP	620..954	CDD:413381	98/343 (29%)
rasal3	XP_002935455.2	PH-like	172..311	CDD:388408	37/188 (20%)
		C2	288..417	CDD:387358	39/148 (26%)
		RasGAP_DAB2IP	408..731	CDD:213338	97/338 (29%)
		BexC_CtrB_KpsE	<863..968	CDD:130083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920