DRSC/TRiP Functional Genomics Resources

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Protein Alignment vap and syngap1b

DIOPT Version :10

Sequence 1:NP_523361.1 Gene:vap / 32569 FlyBaseID:FBgn0003969 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001313396.1 Gene:syngap1b / 100151149 ZFINID:ZDB-GENE-100921-2 Length:1507 Species:Danio rerio


Alignment Length:588 Identity:145/588 - (24%)
Similarity:258/588 - (43%) Gaps:90/588 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   376 KKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCFYDNPKKT-------KPKG---LIDL 430
            :::||.........|.|:|:.::.:.........:.:.....:.|::       .|..   .:||
Zfish   219 RRLKGSIKRAKSQPKLDRTSSFRHMILPRFRSADQERTRLMQSFKESHSHESLLSPSSAAEALDL 283

  Fly   431 SC---AYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQ 492
            :.   |.:...|.|:..:.|||:::..:    .|..:.|..:.|. .:||.:|:        ||.
Zfish   284 TLDEDAIIKPVHSSILGQEYCFEVITAS----GTKCFACRSAAER-DKWIENLQ--------RAV 335

  Fly   493 K--KVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPV-WEEEFVLDD 554
            |  |.:..|....|.|.::||..||.|  ...||.:.|:.:...:|..|...:.| |.|.|..::
Zfish   336 KPNKDNSRRVDNVLKLWIIEARELPPK--KRYYCELCLDDMLYARTTSKPRTDTVFWGEHFEFNN 398

  Fly   555 VPPDVVSLTITLI----SRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEWG----- 610
            :|. |.:|.:.|.    .:.::.|.:.:..::|.:||:...|..|.||.:...:.:.:.|     
Zfish   399 LPA-VRNLRLHLYKETDKKRRKEKSTYLGLVSIPISSITGRQFVEQWYPVIQPSVLAKGGGVGGG 462

  Fly   611 -----SLRLRMRYLDDLIMPCEEYSPLQQLLLES---------ELYAVKALAELCHNDRVPLATA 661
                 ||||:.|:....|:|.|.|....:.:..:         .|.:||:..|        :|.|
Zfish   463 KIINASLRLKSRFQTMSILPMELYKEFAEYVTNNYRTLCAVLEPLLSVKSKEE--------VACA 519

  Fly   662 LLRVFRQEKRETELIRMLCQAEVTR-ENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQ 725
            |:.:.:...:..:.:..:...||.| .:....:||..:|||..::.|::.....:|:..:.:.::
Zfish   520 LVHILQSTGKAKDFLSDMAMCEVDRFIDREHLIFRENTLATKAIEEYLKLIGHKYLKDVLGDFIR 584

  Fly   726 RILESKQSAELNP--TKMDVNDDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVM 788
            .:.||:::.|::|  |...:..:...|   |....:|....|..|..|.||.:        |.|.
Zfish   585 ALYESEENCEVDPMRTPPSILPEHQAN---LRMCCELALCKIINSYCAFPREL--------KEVF 638

  Fly   789 AKWPTERLVR------TRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLA 847
            |.|......|      .|::||.:|||.||||:::|..|.|..|.|....:|:|.::||.:||||
Zfish   639 ASWRVRCAERGREDIADRLISGSLFLRFLCPAIMSPSLFNLTQEYPDEQTSRTLTLIAKVVQNLA 703

  Fly   848 NLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATL 912
            |..:||.||:||..:|.|:......|..||.::|:: |.....|.|.      ...|.||||:.|
Zfish   704 NFSKFGSKEEYMCFMNEFLEMEWGSMQQFLYEISNL-DSVSNAGAFE------GYIDLGRELSIL 761

  Fly   913 HHI 915
            |.:
Zfish   762 HSL 764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
vapNP_523361.1 SH2_Nterm_RasGAP 64..166 CDD:198216
SH3_RasGAP 183..241 CDD:212722
SH2_Cterm_RasGAP 252..326 CDD:198217
PH_RASA1 379..484 CDD:270080 21/117 (18%)
C2_Ras_p21A1 499..622 CDD:176045 35/137 (26%)
RasGAP 620..954 CDD:470620 85/314 (27%)
syngap1bNP_001313396.1 PH-like 208..395 CDD:473070 41/190 (22%)
C2_SynGAP_like 337..483 CDD:175980 37/148 (25%)
RasGAP_DAB2IP 474..808 CDD:213338 86/317 (27%)
DUF3498 798..1430 CDD:463427
Blue background indicates that the domain is not in the aligned region.

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