DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vap and syngap1b

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001313396.1	Gene:	syngap1b / 100151149	ZFINID:	ZDB-GENE-100921-2	Length:	1507	Species:	Danio rerio

Alignment Length:	588	Identity:	145/588 - (24%)
Similarity:	258/588 - (43%)	Gaps:	90/588 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 KKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCFYDNPKKT-------KPKG---LIDL 430
            :::||.........|.|:|:.::.:.........:.:.....:.|::       .|..   .:||
Zfish   219 RRLKGSIKRAKSQPKLDRTSSFRHMILPRFRSADQERTRLMQSFKESHSHESLLSPSSAAEALDL 283

  Fly   431 SC---AYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQ 492
            :.   |.:...|.|:..:.|||:::..:    .|..:.|..:.|. .:||.:|:        ||.
Zfish   284 TLDEDAIIKPVHSSILGQEYCFEVITAS----GTKCFACRSAAER-DKWIENLQ--------RAV 335

  Fly   493 K--KVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPV-WEEEFVLDD 554
            |  |.:..|....|.|.::||..||.|  ...||.:.|:.:...:|..|...:.| |.|.|..::
Zfish   336 KPNKDNSRRVDNVLKLWIIEARELPPK--KRYYCELCLDDMLYARTTSKPRTDTVFWGEHFEFNN 398

  Fly   555 VPPDVVSLTITLI----SRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEWG----- 610
            :|. |.:|.:.|.    .:.::.|.:.:..::|.:||:...|..|.||.:...:.:.:.|
Zfish   399 LPA-VRNLRLHLYKETDKKRRKEKSTYLGLVSIPISSITGRQFVEQWYPVIQPSVLAKGGGVGGG 462

  Fly   611 -----SLRLRMRYLDDLIMPCEEYSPLQQLLLES---------ELYAVKALAELCHNDRVPLATA 661
                 ||||:.|:....|:|.|.|....:.:..:         .|.:||:..|        :|.|
Zfish   463 KIINASLRLKSRFQTMSILPMELYKEFAEYVTNNYRTLCAVLEPLLSVKSKEE--------VACA 519

  Fly   662 LLRVFRQEKRETELIRMLCQAEVTR-ENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQ 725
            |:.:.:...:..:.:..:...||.| .:....:||..:|||..::.|::.....:|:..:.:.::
Zfish   520 LVHILQSTGKAKDFLSDMAMCEVDRFIDREHLIFRENTLATKAIEEYLKLIGHKYLKDVLGDFIR 584

  Fly   726 RILESKQSAELNP--TKMDVNDDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVM 788
            .:.||:::.|::|  |...:..:...|   |....:|....|..|..|.||.:        |.|.
Zfish   585 ALYESEENCEVDPMRTPPSILPEHQAN---LRMCCELALCKIINSYCAFPREL--------KEVF 638

  Fly   789 AKWPTERLVR------TRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLA 847
            |.|......|      .|::||.:|||.||||:::|..|.|..|.|....:|:|.::||.:||||
Zfish   639 ASWRVRCAERGREDIADRLISGSLFLRFLCPAIMSPSLFNLTQEYPDEQTSRTLTLIAKVVQNLA 703

  Fly   848 NLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATL 912
            |..:||.||:||..:|.|:......|..||.::|:: |.....|.|.      ...|.||||:.|
Zfish   704 NFSKFGSKEEYMCFMNEFLEMEWGSMQQFLYEISNL-DSVSNAGAFE------GYIDLGRELSIL 761

  Fly   913 HHI 915
            |.:
Zfish   762 HSL 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722
		SH2_Cterm_RasGAP	252..326	CDD:198217
		PH_RASA1	379..484	CDD:270080	21/117 (18%)
		C2_Ras_p21A1	499..622	CDD:176045	35/137 (26%)
		RasGAP	620..954	CDD:413381	85/314 (27%)
syngap1b	NP_001313396.1	PH-like	208..395	CDD:302622	41/190 (22%)
		C2_SynGAP_like	337..483	CDD:175980	37/148 (25%)
		RasGAP	463..809	CDD:214617	90/328 (27%)
		RasGAP_DAB2IP	474..808	CDD:213338	86/317 (27%)
		DUF3498	798..1430	CDD:288827
		Muted	<1298..1389	CDD:291603
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820