DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vap and rasa1

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001107303.1	Gene:	rasa1 / 100135092	XenbaseID:	XB-GENE-6085075	Length:	946	Species:	Xenopus tropicalis

Alignment Length:	925	Identity:	434/925 - (46%)
Similarity:	596/925 - (64%)	Gaps:	45/925 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LGGIMAPGGIDLGDLAQELDHDEFDGPHMLNGE-RPAIIAPPESEWYHGRLDRYSAESRLRGSSK 103
            :.||:.|  :|        :.|..|||.....| ...:.|||.::||||:|||..||.||..:|:
Frog    45 MSGILGP--VD--------EADSVDGPEYEEEEVEIPLSAPPTNQWYHGKLDRTIAEERLYQASR 99

  Fly   104 LGSYLVRESDRKPGSYVLSYYGRTG-INHFRITAVCGDFYIGGRQFISLSDLVGYYTSCSDLLKR 167
            .||||:|||||:|||:|||:..:|. :.||||.|:|||||||||:|.|||||:|||:..|.|||.
Frog   100 TGSYLIRESDRRPGSFVLSFLSKTNVVTHFRIIAMCGDFYIGGRRFSSLSDLIGYYSHVSCLLKE 164

  Fly   168 ERLAIPVAPPEPVNDKKRVVAILPYTKMPETDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGM 232
            |:|..||||||||.|::||.|||||||:|:|||:||.|||:|.|||::.|||||||..||.|||:
Frog   165 EKLLFPVAPPEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWLWVTNLRTNEQGL 229

  Fly   233 IFRELVDDLDVSIDPNTVFPWFHPNCTKNEAVDMLVKAGP-GSFLVRPSDNSPGDYSLFFHINNQ 296
            |..:||.::....||:....|||...:|.||.::|:..|. .|||||||||:||||||:|..|..
Frog   230 IVEDLVKEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGGISSFLVRPSDNTPGDYSLYFRTNEN 294

  Fly   297 IQRFRI-EKKGVRYLMGGRTFECLDAVINRYRKEQIVEGHSLNHPVVNGIQPEFNQQYVVEK--A 358
            ||||:| .....:::||||.:..:|.:|:.|||||||||:.|..||     |..:|:.|:..  .
Frog   295 IQRFKICPTANNQFMMGGRYYNSIDDIIDHYRKEQIVEGYYLKQPV-----PVQHQEQVLNDFLD 354

  Fly   359 AEKIYATL-RECRDQIGLKKIKGIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCFYDNPKK- 421
            .::||.|: |..:|..    .|.|...|:|.||| |..:||.|||.|  :|::.||.|:::.|:
Frog   355 GKEIYNTIKRRTKDAF----YKNIVKKGYLLKKS-KGKRWKNLYFIL--EGNDAQLIFFESEKRA 412

  Fly   422 TKPKGLIDLSCAYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDS 486
            ||||||.|||...:|..||||:.||.|||||.:.......:.|....:.|...:|:.:|:|.|..
Frog   413 TKPKGLFDLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFACDTPEQAEDWMRTLQAFCCL 477

  Fly   487 QLSRAQKKVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPVWEEEFV 551
            :.........|||::..|||||.|||:||.|....|||:|.||.|:|.||..:....|||.|||.
Frog   478 RKITQSPSNKRLRQVSSLNLHVEEAHKLPMKHFTSPYCNIQLNSVQVAKTHAREGQNPVWSEEFF 542

  Fly   552 LDDVPPDVVSLTITLISRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMG--EWGSLRL 614
            .||:.||:....|.|.::.|:.||.::..:...||.|:.||.|:.|:||:...|:.  |.||||:
Frog   543 FDDLSPDINRFEIILSNKTKKSKDPDILFMRCQLSRLQKGQTTDEWFQLSSHIPLKGIEPGSLRV 607

  Fly   615 RMRYLDDLIMPCEEYSPLQQLLLESELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRML 679
            |.||..:.|||.|||:..::|:|:.||:.|.||:.:|..||..||:.|||:|..||.|:.|:|.|
Frog   608 RARYSMEKIMPEEEYTEFKELILQKELHVVNALSHVCGQDRTLLASILLRIFLHEKMESLLLRTL 672

  Fly   680 CQAEVTRENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVN 744
            ...|:..|:|.|||||..:||:|||:.||:...:.|:..|:.:|:.:|||||||.||||:|::.|
Frog   673 NDREIGMEDEATTLFRATTLASTLMEQYMKATATPFVHHALKDTILKILESKQSCELNPSKLEKN 737

  Fly   745 DDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTERLVRTRVVSGFIFLR 809
            :|...|.:.||.:|..:.:.||.:.:..|..:|:|..||||:|..|||:...:||||||||:|||
Frog   738 EDVNANLQHLLILLSELVEKIFMAAEILPPTLRYIYGCLQKSVQQKWPSNATMRTRVVSGFVFLR 802

  Fly   810 LLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGGKEQYMEVVNPFILKNKERMI 874
            |:|||:||||.|.::|::|...|.|:|.:|||.|||||||:|||.||.|||.|||||..||:|||
Frog   803 LICPAILNPRMFNIISDSPSPTAARTLTLVAKSLQNLANLVEFGAKEPYMEGVNPFIKDNKQRMI 867

  Fly   875 VFLDQLSSVNDPNQPLGMFVEQSTNLNSQDTGRELATLHHICVSHSQELHELSNILS-----IKK 934
            :|||:|.:|  |..|      .:|..:..|..|.||.||.:||:||.||..:||...     :||
Frog   868 MFLDELGNV--PELP------DTTEHSRTDLSRNLAALHEMCVAHSDELRTISNERGAQQHVLKK 924

  Fly   935 LVTVTDMLTKHKLKY 949
            |:.:|::|.:.:.:|
Frog   925 LLAITELLQQKQNQY 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216	60/103 (58%)
		SH3_RasGAP	183..241	CDD:212722	37/57 (65%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	36/75 (48%)
		PH_RASA1	379..484	CDD:270080	45/105 (43%)
		C2_Ras_p21A1	499..622	CDD:176045	55/124 (44%)
		RasGAP	620..954	CDD:413381	158/335 (47%)
rasa1	NP_001107303.1	SH2_Nterm_RasGAP	60..163	CDD:198216	59/102 (58%)
		SH3_RasGAP	180..238	CDD:212722	37/57 (65%)
		SH2_Cterm_RasGAP	249..325	CDD:198217	36/75 (48%)
		PH_RASA1	372..475	CDD:270080	45/105 (43%)
		PH	374..475	CDD:278594	44/103 (43%)
		C2_Ras_p21A1	490..615	CDD:176045	55/124 (44%)
		RasGAP	597..939	CDD:214617	165/349 (47%)
		RasGAP_p120GAP	613..944	CDD:213340	158/335 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5120
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2168
Inparanoid	1	1.050	772	1.000	Inparanoid score	I527
OMA	1	1.010	-	-		QHG48483
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0006956
OrthoInspector	1	1.000	-	-		oto103591
Panther	1	1.100	-	-	LDO	PTHR10194
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5047
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080