DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vap and dab2ipa

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_017212908.1	Gene:	dab2ipa / 100002454	ZFINID:	ZDB-GENE-081104-516	Length:	1256	Species:	Danio rerio

Alignment Length:	544	Identity:	138/544 - (25%)
Similarity:	246/544 - (45%)	Gaps:	81/544 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   428 IDLSC---AYLYQCHDSLWERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLS 489
            :|||.   ..:...|.|:..:.:||::....    .:..:.|..:.|. .:|:.:|:........
Zfish   210 LDLSMEEEVLIKPVHSSILGQDFCFEVTTST----GSKCFSCRSAAER-DKWMENLRRAVHPNKD 269

  Fly   490 RAQKKVSRLRELRCLNLHVLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPV-WEEEFVLD 553
            .. ::|..:  |:|   .::||..||.|  ...:|.:.|:.....:|..|:..:.| |.|.|..:
Zfish   270 NT-RRVENM--LKC---WIIEAKDLPAK--KKYFCELCLDDTLYARTTCKLKTDNVFWGEHFEFN 326

  Fly   554 DVPPDVVSLTITLI----SRGKRGKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMGEWGS--- 611
            :: |.|.|:|:.|.    .:.|:.|::.|..:.|.::::...|..|.||.::  ||....|.
Zfish   327 NL-PSVKSITVHLYKETDKKKKKDKNNYVGLVNIPIATVTGRQFVEKWYSVS--TPNPNKGKSPG 388

  Fly   612 --LRLRMRYLDDLIMPCEEYSPLQQLLLESELYAVKAL-AELCHNDRVPLATALLRVFRQEKRET 673
              :|::.||....|:|.|.|....:.:..:.:.....| ..|...::..:|.||:.:.:...:..
Zfish   389 PMVRMKSRYQSMSILPMELYKEFAEYITNNYMLMCSVLEPALSVKNKEEMACALVHILQSTGKAK 453

  Fly   674 ELIRMLCQAEVTR--ENETTTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQSAEL 736
            :.:..|..:||.|  :|| ..:||..:|||..::.|::.....:||.|:.|.::.:.||.::.|:
Zfish   454 DFLTDLMMSEVDRCGDNE-HLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEV 517

  Fly   737 NPTKMDVNDDACTNAEF------LLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMAKWPTER 795
            :|:|       |::::.      |....:|....|..|....||.:        |.|.|.|..|.
Zfish   518 DPSK-------CSSSDLHEHQSNLKMCCELAFCKIINSYCVFPREL--------KEVFASWRQEC 567

  Fly   796 LVR------TRVVSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVMVAKCLQNLANLIEFGG 854
            ..|      .|::|..:|||.||||:::|..|.|:.|.|.....|:|.::||..|||||..:||.
Zfish   568 SSRGRPDISERLISASLFLRFLCPAIMSPSLFSLMQEYPDDRTARTLTLIAKVTQNLANFTKFGS 632

  Fly   855 KEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGM--FVEQSTNLNSQDTGRELATLHHICV 917
            ||:||..:|.|:......|..||.::|:....:...|.  :|         |.||||::||.:
Zfish   633 KEEYMSFMNQFLEHEWTNMQRFLLEISNPETISNTAGFEGYV---------DLGRELSSLHSL-- 686

  Fly   918 SHSQELHELSNILSIKKLVTVTDM 941
                    ||..:|.....|:|.:
Zfish   687 --------LSEAVSQLDQTTITKL 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216
		SH3_RasGAP	183..241	CDD:212722
		SH2_Cterm_RasGAP	252..326	CDD:198217
		PH_RASA1	379..484	CDD:270080	11/58 (19%)
		C2_Ras_p21A1	499..622	CDD:176045	34/132 (26%)
		RasGAP	620..954	CDD:413381	92/339 (27%)
dab2ipa	XP_017212908.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920