DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vap and rasa1a

DIOPT Version :9

Sequence 1:	NP_001285314.1	Gene:	vap / 32569	FlyBaseID:	FBgn0003969	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_009300041.2	Gene:	rasa1a / 100002155	ZFINID:	ZDB-GENE-030131-4694	Length:	1010	Species:	Danio rerio

Alignment Length:	969	Identity:	433/969 - (44%)
Similarity:	608/969 - (62%)	Gaps:	70/969 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KPGSPTGC---SDDG----NLAGLGGMT-----------GLGGIMAPGGIDLGDLAQELDHDEFD 64
            :..:.|||   |.||    .::...|.|           ||||   .|.:|        :.|:.|
Zfish    53 RAAAATGCESPSSDGPGSSRMSPTDGPTVFPPLPPPPPSGLGG---QGSVD--------ESDQQD 106

  Fly    65 GPHMLNGERPAII----APPESEWYHGRLDRYSAESRLRGSSKLGSYLVRESDRKPGSYVLSYYG 125
            ||..   |...::    |||.::||||.|||..||.|||.:...||||:|||||:|||:|||:..
Zfish   107 GPEY---EEEEVVFPLSAPPTNQWYHGMLDRTIAEERLRQARTPGSYLIRESDRRPGSFVLSFLS 168

  Fly   126 RTG-INHFRITAVCGDFYIGGRQFISLSDLVGYYTSCSDLLKRERLAIPVAPPEPVNDKKRVVAI 189
            .|. :|||||.|:|||:|||||:|.|||||:|||:..|.|||.|:|:.||||||||.|::||.||
Zfish   169 VTSVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSYVSCLLKGEKLSSPVAPPEPVEDRRRVRAI 233

  Fly   190 LPYTKMPETDELSFQKGDIFFVHNDMGDGWLWVTAHRTGEQGMIFRELVDDLDVSIDPNTVFPWF 254
            |||||:|||||:||.|||:|.|||::.|||:|||..||.|||:|..:||:::....||:....|:
Zfish   234 LPYTKVPETDEISFLKGDMFIVHNELEDGWMWVTNVRTEEQGLIVDDLVEEVGREEDPHEGKIWY 298

  Fly   255 HPNCTKNEAVDMLVKAGP-GSFLVRPSDNSPGDYSLFFHINNQIQRFRIE-KKGVRYLMGGRTFE 317
            |...:|.||.::|:..|. .|||||||||:||||||||..|..||||:|. ....:|:||||.:.
Zfish   299 HRKISKQEAYNLLLTVGQVCSFLVRPSDNTPGDYSLFFRTNENIQRFKISPTPNNQYMMGGRYYN 363

  Fly   318 CLDAVINRYRKEQIVEGHSLNHPVVNGIQPEFNQQYVVEKAAE--KIYATL-RECRDQIGLKKIK 379
            .:|.:|.||||||||||::|..||     |...::.|:....:  :||.|: |:.:|..    .|
Zfish   364 SVDDIIERYRKEQIVEGYTLKDPV-----PVQQKEQVLSDLVDGREIYNTIRRKTKDAF----YK 419

  Fly   380 GIKHHGHLNKKSDKTTKWKQLYFALINDGSETQLCFYDNPKK-TKPKGLIDLSCAYLYQCHDSLW 443
            .|...|:|.....|..:||.|||.|  :|::..|.::::.|: ||||||||||...:|..||||:
Zfish   420 NIVKKGYLLFNKGKGKRWKHLYFIL--EGNDAHLIYFESEKRATKPKGLIDLSVCSVYGVHDSLF 482

  Fly   444 ERPYCFQIVERALPCLATVTYLCAPSQESYVEWINSLKAQCDSQLSRAQKKVS-RLRELRCLNLH 507
            .||.|||||.:.......:.|....:.|...:|:..|:..|::.....|...: |||::..|.|:
Zfish   483 GRPNCFQIVVQHFSEEQYIFYFAGETPEQAQDWMKCLQTFCNNLRKPLQTTYNKRLRQVSSLVLY 547

  Fly   508 VLEAHRLPFKLVPHPYCSISLNQVKVGKTRVKIAPEPVWEEEFVLDDVPPDVVSLTITLISRGKR 572
            |.|||:||.|...:|||.||||.|:|.:|..:....||:.|||:.||:..|:....|:|.::.|:
Zfish   548 VEEAHKLPIKHFTNPYCIISLNSVQVARTHPREGQNPVFTEEFIFDDLSCDINRFEISLSNKSKK 612

  Fly   573 GKDSEVAELTIDLSSLKNGQETEGWYQLTGMTPMG--EWGSLRLRMRYLDDLIMPCEEYSPLQQL 635
            .|:|::..:...||.|:.||..:.|:.|:...|:.  |.||||:|:||..:.|||.||||..::|
Zfish   613 SKESDILFMRCQLSKLQRGQMIDEWFPLSSYVPLKGIEPGSLRVRVRYSMEKIMPEEEYSEFKEL 677

  Fly   636 LLESELYAVKALAELCHNDRVPLATALLRVFRQEKRETELIRMLCQAEVTRENETTTLFRGASLA 700
            :|:.:.:.:.|||.:|..||..||:.|||:.|.|:.|..|:|.|...|:..|:|.|||||..:||
Zfish   678 ILQRDYHVIYALAHVCGQDRTLLASILLRILRHERAEALLLRTLNDREINMEDEATTLFRATTLA 742

  Fly   701 TTLMDLYMRTECSGFLQSAVSETVQRILESKQSAELNPTKMDVNDDACTNAEFLLQILDLVTQSI 765
            :|||:.||:...:.|:..|:.:|:.:|:|||||.||||:|::.|:|...|...||.||..:.:.|
Zfish   743 STLMEQYMKATATPFVHHALKDTILKIMESKQSCELNPSKLEKNEDVNLNLAHLLNILSELVEKI 807

  Fly   766 FTSPDACPRNVRFICSCLQKAVMAKWPTERLVRTRVVSGFIFLRLLCPALLNPRQFGLVSETPPM 830
            |.:.:..|..:|:|..||||:|..||||...:||||||||:||||:|||:||||.|.::::.|..
Zfish   808 FMAAEILPPTLRYIYGCLQKSVQQKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIIADPPSS 872

  Fly   831 AATRSLVMVAKCLQNLANLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLSSVNDPNQPLGMFVE 895
            .|.|:|.:|||.:||||||:|||.||.|||.|||||..||:|||:|||:|.:|.|        :.
Zfish   873 TAGRTLTLVAKSVQNLANLVEFGAKEPYMEGVNPFIKNNKQRMIMFLDELGNVPD--------LP 929

  Fly   896 QSTNLNSQDTGRELATLHHICVSHSQELHELSNIL-----SIKKLVTVTDMLTKHKLKY 949
            :||.....|..|:||.||.||.:||.||..|||..     ::|||:.:|::|.:.:::|
Zfish   930 ESTEHFRTDLSRDLAALHEICATHSDELRTLSNERGAQQHALKKLLAITELLQQKQVQY 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vap	NP_001285314.1	SH2_Nterm_RasGAP	64..166	CDD:198216	60/106 (57%)
		SH3_RasGAP	183..241	CDD:212722	37/57 (65%)
		SH2_Cterm_RasGAP	252..326	CDD:198217	37/75 (49%)
		PH_RASA1	379..484	CDD:270080	40/105 (38%)
		C2_Ras_p21A1	499..622	CDD:176045	49/124 (40%)
		RasGAP	620..954	CDD:413381	156/335 (47%)
rasa1a	XP_009300041.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587273
Domainoid	1	1.000	111	1.000	Domainoid score	I6195
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2168
Inparanoid	1	1.050	780	1.000	Inparanoid score	I509
OMA	1	1.010	-	-		QHG48483
OrthoDB	1	1.010	-	-		D145372at2759
OrthoFinder	1	1.000	-	-		FOG0006956
OrthoInspector	1	1.000	-	-		otm25384
orthoMCL	1	0.900	-	-		OOG6_105831
Panther	1	1.100	-	-	LDO	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5207
SonicParanoid	1	1.000	-	-		X5047
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940