DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8939 and ftsj3

DIOPT Version :9

Sequence 1:	NP_573099.1	Gene:	CG8939 / 32568	FlyBaseID:	FBgn0030720	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001292397.1	Gene:	ftsj3 / 321247	ZFINID:	ZDB-GENE-030131-9828	Length:	838	Species:	Danio rerio

Alignment Length:	877	Identity:	373/877 - (42%)
Similarity:	519/877 - (59%)	Gaps:	106/877 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKKTKVGKTRKDKFYQLAKETGLRSRAAFKLIQLNRKFGFLQQSQVCLDLCAAPGGWMQVAKQN 65
            ||||.|||||||||||.||||||.|||::||||||||||.|||:::..:|||||||||:|||.:.
Zfish     1 MGKKLKVGKTRKDKFYHLAKETGYRSRSSFKLIQLNRKFQFLQKARALVDLCAAPGGWLQVASKF 65

  Fly    66 MPVSSIVIGVDLFPIRPIAGCIGLVEDITTEKCRQSLTKELQSWKADVVLHDGAPNVGRNWLYDA 130
            |||||:||||||.||:||...:.|.||||||||||:|.||||:||.||||:|||||||.||.:||
Zfish    66 MPVSSLVIGVDLVPIKPIPNVVTLQEDITTEKCRQALRKELQTWKVDVVLNDGAPNVGANWQHDA 130

  Fly   131 YQQICLTLNALKLSTQFLRNGGWFVTKVFRSKDYNALLWVLKQLFKKVHATKPSASRKESAEIFV 195
            :.|..|||.||||:.:||..||.|:|||||||||..|:|:.:|.||||.||||.|||.|||||||
Zfish   131 FSQANLTLMALKLACEFLAKGGTFITKVFRSKDYQPLMWIFQQFFKKVQATKPQASRNESAEIFV 195

  Fly   196 VCQGYLAPDHIDPRLLDSKYVFEELDLDAKKKSSLLHPEKQKRIKAEGYTAQDIALRNDLAATEF 260
            ||||:||||.||.:..|.|:.|:|:|:..|....|::   :|:.|||||:..|:.|.:....|||
Zfish   196 VCQGFLAPDKIDNKFFDPKHAFKEVDVQVKTVKELVN---KKKPKAEGYSDGDLTLYHKFTITEF 257

  Fly   261 LKAENALAALQGIGSIRIDDQRIANHKKTTPEILECCKDLKVLGRKDIKGLVQWWKDVRELFVEK 325
            |||||.:..|.....|..||..:.:|..|:.||.|||.|:||||||:::.|:.|...:|:...:|
Zfish   258 LKAENPVDFLSKANEITFDDPLLESHPLTSAEIRECCSDVKVLGRKELRLLLSWRSKLRKFLAKK 322

  Fly   326 ---ETPLVVGNAA-----------DEKPKPLTQAEIEDMEDAELQTQIETIVEEEKKDLKRKRKK 376
               |...:...|:           :.|.|...:.:.|:.||..::.::..:..||..:||||:||
Zfish   323 LRQEAKQLDQEASSDDEQSDTDEKESKKKKSEEKKEEEDEDEAMEKKLTELKAEEFAELKRKKKK 387

  Fly   377 TLKTKAKLHEKMNLNMVIKG----DDGPVEEMEHEIFDLKNIRTSAELDELLDVQPDFAVDESQP 437
            .||.:.|..|::.|.|.:.|    |.|     :..:|.|.:||.|..|.:|  .|.|.:..::..
Zfish   388 LLKERRKQRERVELKMDLPGVSIADAG-----DSSMFSLGSIRKSQGLHQL--AQGDMSAADALL 445

  Fly   438 EETKLPKYKYFDKDEGNINDDLNYDDDNDEEQSEASD-DEDQINDKQGLGLSDDDNDEGNAKGKN 501
            |:.        ::::.:::|    ::..||..|.||| |.|.:.:.|       ..:|...|.|.
Zfish   446 EDD--------EQEDVHLSD----EEQEDERMSLASDLDSDDLQEIQ-------QKEEQMLKNKP 491

  Fly   502 KRKKR------------SENPLIKSNDFRDKNTKREQRVQLWYEKDVLQNIQSDDDEETYDLNNL 554
            |:||:            ::|.|:.  :...|:.::|:...:|:.||:...:..:||.:..:
Zfish   492 KKKKKVSFEQQDDGDEDNKNELLV--ELEGKDERKERETSMWFSKDIFAELDLNDDTDAMN---- 550

  Fly   555 AKEFKAKGVAVLGESTLTPDANEEVVQGKKAKRRARHETATKDSSSESSESED-DANEDSDGEQ- 617
              |.|...:...|.........||..:.||.:::    .||  .|.|..|:|| |:::.||.|:
Zfish   551 --ELKQTQILQTGRGKKRKAQQEEEAEPKKPEQK----VAT--PSQEVKEAEDSDSDDSSDDERE 607

  Fly   618 --------PAAGTNA----------------KKVRLSENE-MALGALLTRSKKTRRDLIDAAWNR 657
                    .|.|||.                |:.|:.:.| :||||.:..|||..|||||.:::|
Zfish   608 IAQMKQASAAVGTNGAEENDNIQVIPVEKTNKRARVLDAEGLALGAQIATSKKRERDLIDGSFHR 672

  Fly   658 YAFNDE--NVPVWFKLDEDEHMTKPTPVPKELTAEYQRKLQEVNVRPIKKVMEAKARKHRRATKR 720
            :|.:::  .||.||..||.:|..:|.||.|::..||::|.:|:|.|||::|.||||||.||..|:
Zfish   673 FANSEDMTEVPAWFVDDEKKHRKRPVPVTKDMVEEYKQKWKEINARPIRRVAEAKARKKRRTLKK 737

  Fly   721 LAKAKKMAEKIMENSDATNHEKSKQLKKVYKKA--QEKKKEVTYVVAKKQTAARRARRPAGVKGR 783
            :.:|||.||.::...|.:..||..|||.:||||  .::|:||||||||| ...||.||||||||.
Zfish   738 MEQAKKKAEAVVNTVDISEREKMAQLKSIYKKAGVGKEKREVTYVVAKK-GVGRRVRRPAGVKGA 801

  Fly   784 YKVVDPREKKDKRSMDAKKRREKGSKGRKGKG 815
            :||||.|.|||.|:...|..|.:|..||..||
Zfish   802 FKVVDGRMKKDTRAAQRKDERGRGKGGRGSKG 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8939	NP_573099.1	RlmE	8..203	CDD:223370	139/194 (72%)
		DUF3381	233..366	CDD:288694	45/146 (31%)
		Spb1_C	611..803	CDD:285075	98/221 (44%)
ftsj3	NP_001292397.1	RlmE	4..203	CDD:223370	142/198 (72%)
		DUF3381	233..377	CDD:288694	45/143 (31%)
		Spb1_C	624..819	CDD:285075	90/195 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579435
Domainoid	1	1.000	257	1.000	Domainoid score	I1988
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5451
Inparanoid	1	1.050	623	1.000	Inparanoid score	I845
OMA	1	1.010	-	-		QHG53535
OrthoDB	1	1.010	-	-		D1362679at2759
OrthoFinder	1	1.000	-	-		FOG0005092
OrthoInspector	1	1.000	-	-		oto39136
orthoMCL	1	0.900	-	-		OOG6_101655
Panther	1	1.100	-	-	LDO	PTHR10920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3614
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910