DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8939 and Ftsj3

DIOPT Version :9

Sequence 1:	NP_573099.1	Gene:	CG8939 / 32568	FlyBaseID:	FBgn0030720	Length:	817	Species:	Drosophila melanogaster
Sequence 2:	NP_001012014.1	Gene:	Ftsj3 / 303608	RGDID:	1307110	Length:	829	Species:	Rattus norvegicus

Alignment Length:	868	Identity:	349/868 - (40%)
Similarity:	509/868 - (58%)	Gaps:	95/868 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKKTKVGKTRKDKFYQLAKETGLRSRAAFKLIQLNRKFGFLQQSQVCLDLCAAPGGWMQVAKQN 65
            ||||.||||:|:||||.||||||.|||:|||||||||:|.|||:::..||||||||||:|||.:.
  Rat     1 MGKKGKVGKSRRDKFYHLAKETGYRSRSAFKLIQLNRRFQFLQKARALLDLCAAPGGWLQVAAKF 65

  Fly    66 MPVSSIVIGVDLFPIRPIAGCIGLVEDITTEKCRQSLTKELQSWKADVVLHDGAPNVGRNWLYDA 130
            |||||:::||||.||:|:...:.|.||||||:|||:|.|||::||.||||:|||||||.:|::||
  Rat    66 MPVSSLIVGVDLVPIKPLPNVVTLQEDITTERCRQALRKELKTWKVDVVLNDGAPNVGASWVHDA 130

  Fly   131 YQQICLTLNALKLSTQFLRNGGWFVTKVFRSKDYNALLWVLKQLFKKVHATKPSASRKESAEIFV 195
            |.|..|||.||:|:..||..||.|:||||||:||..|||:.:|||.:|.||||.|||.|||||||
  Rat   131 YSQAHLTLMALRLACDFLARGGCFITKVFRSRDYQPLLWIFQQLFHRVQATKPQASRHESAEIFV 195

  Fly   196 VCQGYLAPDHIDPRLLDSKYVFEELDLDAKKKSSLLHPEKQKRIKAEGYTAQDIALRNDLAATEF 260
            ||||:||||.:|.:..|.|:.|:|:::.||..:.|:   .:|:.|||||...|:.|.:..:.|:|
  Rat   196 VCQGFLAPDKVDAKFFDPKFAFKEVEVQAKTVTELV---TKKKPKAEGYAEGDLTLYHRTSVTDF 257

  Fly   261 LKAENALAALQGIGSIRIDDQRIANHKKTTPEILECCKDLKVLGRKDIKGLVQWWKDVRELFVEK 325
            |:|.|.:..|.....|.|||:.:|.|..||.:|..||:|:||||||:::.|:.|...:|....:|
  Rat   258 LRAANPVDFLSKASEISIDDKELAQHPATTEDIRACCQDIKVLGRKELRSLLNWRTKLRRYVAKK 322

  Fly   326 --------ETPLVVGNAADE-----KPKPLTQAEIEDMEDAELQTQIETIVEEEKKDLKRKRKKT 377
                    :..|......||     :.|..::.|.|..|:.:|...:..:..:|..:||||:||.
  Rat   323 LKEQAKALDISLSSEEEGDEEESAAETKQASEEEEEREEEEQLNRTLAEMKAQEVAELKRKKKKL 387

  Fly   378 LKTKAKLHEKMNLNMVIKG----DDGPVEEMEHEIFDLKNIRTSAELDEL----LDVQPDFAVDE 434
            |:.:.|..|::.|.|.:.|    |:|     |..:|.|:.||....|:|:    ::....|..|
  Rat   388 LREQRKQRERVELKMDLPGVSIADEG-----ETGMFSLRTIRGQQLLEEVTQGDMNAADTFLSD- 446

  Fly   435 SQPEETKLPKYKYFDKDEGNINDDLNYDDDNDEEQSEASDDEDQINDKQGLGLSDDDNDEGN--- 496
                   ||:            ||:...|..|::.:....|.|. .:..|:....|..::.:
  Rat   447 -------LPR------------DDIYVSDAEDDDDTSLESDLDP-EELAGVRTHSDQKEQKSLQF 491

  Fly   497 AKGKNKRKKRSENPLIKSNDFRDKNTKREQRVQLWYEKDVLQNIQSDDDEETYDLNNLAKEFKAK 561
            |:..:.:::..||||:.  ...:|...:|::..||:.||....| .||.:|..:::.....:|::
  Rat   492 AQVDDSKEEEGENPLLV--PLEEKAVLQEEQASLWFSKDGFSGI-DDDADEALEISQAQLLYKSR 553

  Fly   562 GVAVLGESTLTPDANEEVVQGKKAKRRARHETA---------------TKDSSSESSESEDD--- 608
            ...........|..|   ::.:|...:.::|..               :.||.|.|||.|||
  Rat   554 QKEQQPTDPPPPPTN---LKTEKKSSQCQNEVPKETEAITDTGGEDRDSSDSDSSSSEDEDDWKV 615

  Fly   609 ---------ANEDSDGEQPAAGTNAKKVRLSENE-MALGALLTRSKKTRRDLIDAAWNRYAFN-- 661
                     :..|.||.:.....:..|.|:.:.| :||||::..|||.:|||||.::||||||
  Rat   616 SRGKKRSRGSKADEDGFEVVPIEDPVKYRILDPEGLALGAVIASSKKAKRDLIDNSFNRYAFNEE 680

  Fly   662 DENVPVWFKLDEDEHMTKPTPVPKELTAEYQRKLQEVNVRPIKKVMEAKARKHRRATKRLAKAKK 726
            :|.:|.||..:|.:|..:..|:.|:....|:::.:|:|.||||||.||||||.||..|:|.:.||
  Rat   681 EEELPEWFVQEEKQHRIRQLPLDKKEVEHYRKRWREINARPIKKVAEAKARKKRRMLKKLEQTKK 745

  Fly   727 MAEKIMENSDATNHEKSKQLKKVYKKA--QEKKKEVTYVVAKKQTAARRARRPAGVKGRYKVVDP 789
            .||.::...|.:..||..||:.:||||  .::|::|||||||| ...|:.||||||:|.:||||.
  Rat   746 KAEAVVNTVDISEREKVAQLRSLYKKAGLGKEKRQVTYVVAKK-GVGRKVRRPAGVRGHFKVVDS 809

  Fly   790 REKKDKRSMDAKKRREKGSKGRK 812
            |.|||:|   |:::.:|.:..||
  Rat   810 RMKKDQR---AQRKEQKRNHRRK 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8939	NP_573099.1	RlmE	8..203	CDD:223370	131/194 (68%)
		DUF3381	233..366	CDD:288694	44/145 (30%)
		Spb1_C	611..803	CDD:285075	91/196 (46%)
Ftsj3	NP_001012014.1	RlmE	8..203	CDD:223370	131/194 (68%)
		DUF3381	232..>329	CDD:403157	36/96 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..367		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..508		17/85 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..634		22/109 (20%)
		Spb1_C	628..823	CDD:400230	91/198 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..829		18/37 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339675
Domainoid	1	1.000	250	1.000	Domainoid score	I2048
eggNOG	1	0.900	-	-		E1_COG0293
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5451
Inparanoid	1	1.050	590	1.000	Inparanoid score	I954
OMA	1	1.010	-	-		QHG53535
OrthoDB	1	1.010	-	-		D1362679at2759
OrthoFinder	1	1.000	-	-		FOG0005092
OrthoInspector	1	1.000	-	-		oto97471
orthoMCL	1	0.900	-	-		OOG6_101655
Panther	1	1.100	-	-	LDO	PTHR10920
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3614
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770