DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment exd and TGIF2LX

DIOPT Version :9

Sequence 1:	NP_001259592.1	Gene:	exd / 32567	FlyBaseID:	FBgn0000611	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_620410.3	Gene:	TGIF2LX / 90316	HGNCID:	18570	Length:	241	Species:	Homo sapiens

Alignment Length:	136	Identity:	31/136 - (22%)
Similarity:	63/136 - (46%)	Gaps:	26/136 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 RRKRRNFSKQASEILNEYFYSHLSNPYPSEEAKEELARKCGITVSQVSNWFGNKR-------IRY 296
            ::::.|...::.:||.::.|.|....|||||.|:.|:.|..:::.|:||||.|.|       ::.
Human    51 KKRKGNLPAESVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLSLLQISNWFINARRRILPDMLQQ 115

  Fly   297 KKN-------IGKAQEEANLYAAKKAAGASPYSMAGPPSGTTTPMMSPAPPQDSMGYPMGSGGYD 354
            ::|       .||.....:|.:.:.:..|.. ..:||.:..:.|:           :|:..|...
Human   116 RRNDPIIGHKTGKDAHATHLQSTEASVPAKS-GPSGPDNVQSLPL-----------WPLPKGQMS 168

  Fly   355 QQQPYD 360
            :::..|
Human   169 REKQPD 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
exd	NP_001259592.1	PBC	41..237	CDD:397732
exd	NP_001259592.1	homeodomain	239..299	CDD:238039	20/66 (30%)
TGIF2LX	NP_620410.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		1/6 (17%)
		Homeobox_KN	68..107	CDD:283551	17/38 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..210		10/61 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840