DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment exd and pbx3b

DIOPT Version :9

Sequence 1:	NP_001259592.1	Gene:	exd / 32567	FlyBaseID:	FBgn0000611	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_009302358.1	Gene:	pbx3b / 58140	ZFINID:	ZDB-GENE-000405-3	Length:	471	Species:	Danio rerio

Alignment Length:	350	Identity:	261/350 - (74%)
Similarity:	281/350 - (80%)	Gaps:	34/350 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GGMMAPQGYGLSGQD-DGQNAGSENEVRKQKDIGEILQQIMSISEQSLDEAQA--RKHTLNCHRM 73
            |||..|..:|..|.| ||         ||| |||:||.|||:|::||||||||  |||.||||||
Zfish    23 GGMALPPPHGHDGTDGDG---------RKQ-DIGDILHQIMTITDQSLDEAQAKHRKHGLNCHRM 77

  Fly    74 KPALFSVLCEIKEKTVLSIRNTQEEEPPDPQLMRLDNMLIAEGVAGPEKGGGGAAAASAAAASQG 138
            |||||||||||||||.||||..|||:|||||||||||||:||||||||||||.||||:||||:
Zfish    78 KPALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAAA-- 140

  Fly   139 GSLSIDGADNAIEHSDYRAKLAQIRQIYHQELEKYEQACNEFTTHVMNLLREQSRTRPITPKEIE 203
            ||    ..||:||||||||||:|||||||.|||||||||||||||||||||||||||||:|||||
Zfish   141 GS----PTDNSIEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIE 201

  Fly   204 RMVQIIHKKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQASEILNEYFYSHLSNPYPSE 268
            |||.|||:||||||||||||||||||||||||||||||||||||||:||||||||||||||||||
Zfish   202 RMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYSHLSNPYPSE 266

  Fly   269 EAKEELARKCGITVS----------QVSNWFGNKRIRYKKNIGKAQEEANLYAAKKAAGASPYSM 323
            |||||||:||.||||          |||||||||||||||||||.||||||||||.|..|:..:.
Zfish   267 EAKEELAKKCSITVSQGVGTTITVAQVSNWFGNKRIRYKKNIGKFQEEANLYAAKTAVTAAHAAA 331

  Fly   324 AGPPSGTTTPMMSPAPPQDSMGYPM 348
            |...:..|.   ||..|  :.|:.|
Zfish   332 AAVQNSQTN---SPTTP--NSGFQM 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
exd	NP_001259592.1	PBC	41..237	CDD:397732	166/197 (84%)
exd	NP_001259592.1	homeodomain	239..299	CDD:238039	56/69 (81%)
pbx3b	XP_009302358.1	PBC	42..235	CDD:281746	168/199 (84%)
pbx3b	XP_009302358.1	homeodomain	237..307	CDD:238039	56/69 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587159
Domainoid	1	1.000	332	1.000	Domainoid score	I1115
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	490	1.000	Inparanoid score	I1376
OMA	1	1.010	-	-		QHG48762
OrthoDB	1	1.010	-	-		D348471at33208
OrthoFinder	1	1.000	-	-		FOG0000743
OrthoInspector	1	1.000	-	-		otm24544
orthoMCL	1	0.900	-	-		OOG6_104641
Panther	1	1.100	-	-	O	PTHR11850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910