DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment exd and PKNOX1

DIOPT Version :9

Sequence 1:	NP_001259592.1	Gene:	exd / 32567	FlyBaseID:	FBgn0000611	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_004562.2	Gene:	PKNOX1 / 5316	HGNCID:	9022	Length:	436	Species:	Homo sapiens

Alignment Length:	426	Identity:	76/426 - (17%)
Similarity:	138/426 - (32%)	Gaps:	162/426 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MMAPQGYGLSGQDDGQNAGSENEVRKQKD--------IGEILQQIMSISEQSLDEAQARKHTLNC 70
            |||.|...:....|||......|::.::|        .|.....:.|.:...:|:....:|
Human     1 MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYRH---- 61

  Fly    71 HRMKPALFSVLCEIKEKTVLS-------------------IRNTQEEEPP----DPQLMRLDNML 112
                 .||.:|..:.||...|                   :|..::|..|    ||:   .||::
Human    62 -----PLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPE---TDNLM 118

  Fly   113 IAEGVAGPEKGGGGAAAASAAAASQGGSLSIDGADNAIEHSDYRAKLAQIRQIYHQELEKYEQAC 177
            :                                            |..|:.:|:..||||..:.|
Human   119 V--------------------------------------------KAIQVLRIHLLELEKVNELC 139

  Fly   178 NEFTTHVMNLLREQSRTR------------PITPKEIERMV------------------------ 206
            .:|.:..:..|:.:..:.            |:..::|:..:
Human   140 KDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTISPQGIVVPASALQQGNVAMA 204

  Fly   207 ------------------QIIHKKF---------SSIQMQLKQSTCEAVMILRSRFLDARRKRRN 244
                              |::.:..         |.:|:||.|.    :.||......::.||..
Human   205 TVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQD----LSILHQDDGSSKNKRGV 265

  Fly   245 FSKQASEILNEYFYSHLSNPYPSEEAKEELARKCGITVSQVSNWFGNKRIRYKKNIGKAQEEANL 309
            ..|.|:.::..:.:.|:.:|||:|:.|:::|.:..:|:.||:|||.|.|.|..:.:..:......
Human   266 LPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETP 330

  Fly   310 YAAKKAAGASPYSMAGP---PSGTTTPMMSPAPPQD 342
            ...||.|...|.....|   .||...|     ||.:
Human   331 KTKKKTAQNRPVQRFWPDSIASGVAQP-----PPSE 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
exd	NP_001259592.1	PBC	41..237	CDD:397732	38/289 (13%)
exd	NP_001259592.1	homeodomain	239..299	CDD:238039	20/59 (34%)
PKNOX1	NP_004562.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		11/47 (23%)
		Meis_PKNOX_N	80..165	CDD:406806	17/131 (13%)
		Homeobox_KN	277..316	CDD:399131	15/38 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152675
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840