Protein Alignment exd and MEIS2

DIOPT Version :10

• Sequence 1: NP_523360.1
• Gene: exd / 32567
• FlyBaseID: FBgn0000611
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_733775.1
• Gene: MEIS2 / 4212
• HGNCID: 7001
• Length: 477
• Species: Homo sapiens
• Alignment Length: 179
• Identity: 50/179 - (27%)
• Similarity: 74/179 - (41%)
• Gaps: 46/179 - (25%)

  Fly   239 RRKRRNFSKQASEILNEYFYSHLSNPYPSEEAKEELARKCGITVSQVSNWFGNKRIRYKKNIGKA 303
            ::||..|.|.|:.|:..:.:.||::||||||.|::||:..|:|:.||:|||.|.|.|..:.:...
Human   277 QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQ 341

  Fly   304 QEEANLYAAKKAAGASPYSMAGPPSGT-------------------------------------- 330
            ...|........:..:.||..|.|.|:
Human   342 SNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPS 406

  Fly   331 -TTPMMSPAPPQDSMGYPMGSGGYDQQQPYDNSM---GGYDPNLHQDLS 375
             |.|.|:|.|.|...|.||.|  |....|:..:|   ||  |..|..::
Human   407 YTPPQMTPHPTQLRHGPPMHS--YLPSHPHHPAMMMHGG--PPTHPGMT 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
exd	NP_523360.1	PBC	42..237	CDD:461052
		homeodomain	239..299	CDD:238039	27/59 (46%)
MEIS2	NP_733775.1	Required for interaction with PBX1. /evidence=ECO:0000250	71..191
		Meis_PKNOX_N	110..194	CDD:465140
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	193..283		2/5 (40%)
		Homeobox_KN	295..333	CDD:428673	20/37 (54%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|Ref.16	299..333		19/33 (58%)
		Transcriptional activation domain	340..477		23/116 (20%)