DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment exd and MEIS1

DIOPT Version :9

Sequence 1:	NP_001259592.1	Gene:	exd / 32567	FlyBaseID:	FBgn0000611	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_002389.1	Gene:	MEIS1 / 4211	HGNCID:	7000	Length:	390	Species:	Homo sapiens

Alignment Length:	435	Identity:	90/435 - (20%)
Similarity:	146/435 - (33%)	Gaps:	147/435 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAHTGGMMAPQGYGLSGQDDGQNAGSENEVRKQKDIGEILQQIMSISEQSLDEAQARKHTLNCHR 72
            |.|.|||   .|.|:.....|....:.:           :|.:..::......:....||.:.:.
Human     8 LPHYGGM---DGVGIPSTMYGDPHAARS-----------MQPVHHLNHGPPLHSHQYPHTAHTNA 58

  Fly    73 MKPA--------------------LFSVLCEIKEKTVLSIRNTQEEEPPDPQLMRLDNMLIAEGV 117
            |.|:                    ||.:|..|.||..|:...     |.:|            ||
Human    59 MAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCT-----PREP------------GV 106

  Fly   118 AGPEKGGGGAAAASAAAASQGGSLSIDGADNAIEHSDYRA----------------KLAQIRQIY 166
            |      ||...:|.:.          ..|.|:.....||                :..|:.:.:
Human   107 A------GGDVCSSESF----------NEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFH 155

  Fly   167 HQELEKYEQACNEFTTHVMNLLREQSRTRPI-------------TPKEIERMVQII--------- 209
            ..||||..:.|:.|....::.|:.:   .||             ..::|.|...:.
Human   156 LLELEKVHELCDNFCHRYISCLKGK---MPIDLVIDDREGGSKSDSEDITRSANLTDQPSWNRDH 217

  Fly   210 ------------------HKKFSSIQMQLKQSTCEAVMILRSRFLD-------ARRKRRN-FSKQ 248
                              |...|......:....:..:...|...|       .|.|:|. |.|.
Human   218 DDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKV 282

  Fly   249 ASEILNEYFYSHLSNPYPSEEAKEELARKCGITVSQVSNWFGNKRIRYKKNIGKAQEEANLYAAK 313
            |:.|:..:.:.||::||||||.|::||:..|:|:.||:|||.|.|   ::.:....:::|    :
Human   283 ATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINAR---RRIVQPMIDQSN----R 340

  Fly   314 KAAGASPYSMAGPPSG-----TTTPMMSPAP-PQDSMGYPMGSGG 352
            ..:..:||:..|.|.|     ....|...|| |...||..||..|
Human   341 AVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEG 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
exd	NP_001259592.1	PBC	41..237	CDD:397732	39/271 (14%)
exd	NP_001259592.1	homeodomain	239..299	CDD:238039	27/60 (45%)
MEIS1	NP_002389.1	Meis_PKNOX_N	108..192	CDD:406806	17/96 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..279		9/88 (10%)
		Homeobox_KN	290..329	CDD:399131	20/41 (49%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:26550823, ECO:0000305\|PubMed:28473536	299..329		17/32 (53%)
		Required for transcriptional activation. /evidence=ECO:0000250	335..390		15/55 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840