DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment exd and pbx3a

DIOPT Version :9

Sequence 1:	NP_001259592.1	Gene:	exd / 32567	FlyBaseID:	FBgn0000611	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_005171793.1	Gene:	pbx3a / 387532	ZFINID:	ZDB-GENE-031218-1	Length:	457	Species:	Danio rerio

Alignment Length:	359	Identity:	255/359 - (71%)
Similarity:	283/359 - (78%)	Gaps:	32/359 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDPNRMLAHTGGM-MAPQGYGLSGQDDGQNAGSENEVRKQKDIGEILQQIMSISEQSLDEAQAR 64
            |||...::...||: :|.....|....||          ||:|||:||||||:|::||||||||:
Zfish     1 MEDQTHLMQTLGGVTLAGHPLSLPAPHDG----------KQQDIGDILQQIMTITDQSLDEAQAK 55

  Fly    65 KHTLNCHRMKPALFSVLCEIKEKTVLSIRNTQEEEPPDPQLMRLDNMLIAEGVAGPEKGGGGAAA 129
            ||.|||||||||||||||||||||.||:|::|:|||.|||||||||||:||||:|||||.|.||.
Zfish    56 KHGLNCHRMKPALFSVLCEIKEKTGLSMRSSQDEEPTDPQLMRLDNMLLAEGVSGPEKGSGAAAV 120

  Fly   130 ASAAAASQGGSLSIDGADNAIEHSDYRAKLAQIRQIYHQELEKYEQACNEFTTHVMNLLREQSRT 194
            |:|.||     :.: ||||:||||||||||:|||||||.||||||||||||||||||||||||||
Zfish   121 AAATAA-----VGV-GADNSIEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRT 179

  Fly   195 RPITPKEIERMVQIIHKKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQASEILNEYFYS 259
            |||:||||||||.|||:||||||||||||||||||||||||||||||||||||||:|||||||||
Zfish   180 RPISPKEIERMVNIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQATEILNEYFYS 244

  Fly   260 HLSNPYPSEEAKEELARKCG----------ITVSQVSNWFGNKRIRYKKNIGKAQEEANLYAAKK 314
            ||||||||||||||||:||.          |||||||||||||||||||||||.||||||||||.
Zfish   245 HLSNPYPSEEAKEELAKKCAITVSQGKGSTITVSQVSNWFGNKRIRYKKNIGKFQEEANLYAAKT 309

  Fly   315 AAGASPYSMAGPPSGTTTPMMSPAPPQDSMGYPM 348
            |..|:....|...:....   |||.|  |.|:.|
Zfish   310 AVTAAQAVAAAVQNSQNN---SPATP--SSGFQM 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
exd	NP_001259592.1	PBC	41..237	CDD:397732	160/195 (82%)
exd	NP_001259592.1	homeodomain	239..299	CDD:238039	56/69 (81%)
pbx3a	XP_005171793.1	PBC	32..222	CDD:281746	160/195 (82%)
pbx3a	XP_005171793.1	homeodomain	224..294	CDD:238039	56/69 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587162
Domainoid	1	1.000	332	1.000	Domainoid score	I1115
eggNOG	1	0.900	-	-		E1_KOG0774
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	490	1.000	Inparanoid score	I1376
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D348471at33208
OrthoFinder	1	1.000	-	-		FOG0000743
OrthoInspector	1	1.000	-	-		otm24544
orthoMCL	1	0.900	-	-		OOG6_104641
Panther	1	1.100	-	-	O	PTHR11850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760