DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment exd and pbx1

DIOPT Version :9

Sequence 1:	NP_001259592.1	Gene:	exd / 32567	FlyBaseID:	FBgn0000611	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_012816136.1	Gene:	pbx1 / 100216094	XenbaseID:	XB-GENE-1217592	Length:	454	Species:	Xenopus tropicalis

Alignment Length:	378	Identity:	270/378 - (71%)
Similarity:	296/378 - (78%)	Gaps:	27/378 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MED-PNRMLAHTGGMMAPQGYGLSGQDDGQNAGSENEVRKQKDIGEILQQIMSISEQSLDEAQAR 64
            |:| |..|.:|.|..||..........||..| :|.|..:::|||:||||||:|::|||||||||
Frog     1 MDDQPRLMHSHPGVGMAGHPSLSQHMQDGTGA-NEGEGGRKQDIGDILQQIMTITDQSLDEAQAR 64

  Fly    65 KHTLNCHRMKPALFSVLCEIKEKTVLSIRNTQEEEPPDPQLMRLDNMLIAEGVAGPEKGGGGAAA 129
            ||.|||||||||||:||||||||||||||..|||||.|||||||||||:||||||||||||.|||
Frog    65 KHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPADPQLMRLDNMLLAEGVAGPEKGGGSAAA 129

  Fly   130 ASAAAASQGGSLSIDGADNAIEHSDYRAKLAQIRQIYHQELEKYEQACNEFTTHVMNLLREQSRT 194
            |:|||||.|.     ||||:.|||||||||:|||||||.||||||||||||||||||||||||||
Frog   130 AAAAAASGGA-----GADNSAEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRT 189

  Fly   195 RPITPKEIERMVQIIHKKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFSKQASEILNEYFYS 259
            |||:||||||||.|||:||||||||||||||||||||||||||||||||||:|||:|||||||||
Frog   190 RPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYS 254

  Fly   260 HLSNPYPSEEAKEELARKCGITVSQVSNWFGNKRIRYKKNIGKAQEEANLYAAKKAAGASPYSMA 324
            ||||||||||||||||:||.|||||||||||||||||||||||.|||||:||||.|..|:..|:.
Frog   255 HLSNPYPSEEAKEELAKKCAITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVNATNVSVH 319

  Fly   325 GPPSGTTTPMMSPAPPQDSMGYPMGSGGYDQQQPYDNSMGGYDP-NLHQDLSP 376
            |..:.      ||:.|        .|.|..|.:     .|...| |..|.|||
Frog   320 GSQAN------SPSTP--------SSAGSKQTE-----RGAVQPQNKMQFLSP 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
exd	NP_001259592.1	PBC	41..237	CDD:397732	168/195 (86%)
exd	NP_001259592.1	homeodomain	239..299	CDD:238039	55/59 (93%)
pbx1	XP_012816136.1	PBC	40..232	CDD:367661	168/196 (86%)
pbx1	XP_012816136.1	homeodomain	234..294	CDD:238039	55/59 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1123
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20574
Inparanoid	1	1.050	500	1.000	Inparanoid score	I1330
OMA	1	1.010	-	-		QHG48762
OrthoDB	1	1.010	-	-		D348471at33208
OrthoFinder	1	1.000	-	-		FOG0000743
OrthoInspector	1	1.000	-	-		otm48344
Panther	1	1.100	-	-	O	PTHR11850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4561
SonicParanoid	1	1.000	-	-		X78
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110