DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF5 and TIF5

DIOPT Version :9

Sequence 1:	NP_573098.1	Gene:	eIF5 / 32566	FlyBaseID:	FBgn0030719	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_015366.1	Gene:	TIF5 / 856154	SGDID:	S000006245	Length:	405	Species:	Saccharomyces cerevisiae

Alignment Length:	432	Identity:	158/432 - (36%)
Similarity:	251/432 - (58%)	Gaps:	40/432 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TVNVNRSVTDIFYRYKMPRLQAKVEGKGNGIKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTL 67
            ::|:.|...|.|||||||.:||||||:||||||.::|:|:::.|:.|||.|..||||.||||||.
Yeast     2 SINICRDNHDPFYRYKMPPIQAKVEGRGNGIKTAVLNVADISHALNRPAPYIVKYFGFELGAQTS 66

  Fly    68 FDHKNERFVVNGSHDVNKLQDLLDGFIRKFVLCPECDNPETNLTVSAKNQTISQSCKACGFHGLL 132
            .....:|::|||.|:..||||:|||||.|||||..|.||||.:.::..|..: :.|||||....:
Yeast    67 ISVDKDRYLVNGVHEPAKLQDVLDGFINKFVLCGSCKNPETEIIITKDNDLV-RDCKACGKRTPM 130

  Fly   133 KVNHKVNTFIVKNPPSLNPAAQGSSLTEGKRSRKQKQKNDNADG---SMTNNSLANNSGGESDG- 193
            .:.||:::||:||||        .|::..|:.:|....:.|..|   |:::.:...:....|||
Yeast   131 DLRHKLSSFILKNPP--------DSVSGSKKKKKAATASANVRGGGLSISDIAQGKSQNAPSDGT 187

  Fly   194 GNGTNQ-ASQTEAEISAAIPEKTAKDDD----DEGWSVDVSKEAIRARLQDLTDGAKGMTISDDY 253
            |:.|.| ..:.|.|:|..|....:..:|    |:.|:||:|:||||||.::|...:: :|..|:|
Yeast   188 GSSTPQHHDEDEDELSRQIKAAASTLEDIEVKDDEWAVDMSEEAIRARAKELEVNSE-LTQLDEY 251

  Fly   254 DKTEKERIDIFYELVKDKRDKKQL-DDVQTHKELVIEAERLDIIN--KAPLVLAELLFTENIIKD 315
            .:         :.|.:...||:.| .||:.:|    :|..||::|  |...|||:.||.|:|:.:
Yeast   252 GE---------WILEQAGEDKENLPSDVELYK----KAAELDVLNDPKIGCVLAQCLFDEDIVNE 303

  Fly   316 VQKNRPLLLRFTLNNPKAQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQK 380
            :.::.....:. |..|:.::..:||:|:.:.|....|:..:..|....|:.||:.|..|:.:..|
Yeast   304 IAEHNAFFTKI-LVTPEYEKNFMGGIERFLGLEHKDLIPLLPKILVQLYNNDIISEEEIMRFGTK 367

  Fly   381 VSKRHVSKNIAAEIHEKAMPFVLWLKNAEEESSESEEEEDDE 422
            .||:.|.|.::.::...|.||:.||:.||.:    ::|||||
Yeast   368 SSKKFVPKEVSKKVRRAAKPFITWLETAESD----DDEEDDE 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF5	NP_573098.1	eIF-5_eIF-2B	10..127	CDD:280114	65/116 (56%)
eIF5	NP_573098.1	W2_eIF5	254..408	CDD:211399	42/156 (27%)
TIF5	NP_015366.1	eIF-5_eIF-2B	8..127	CDD:396445	67/119 (56%)
TIF5	NP_015366.1	W2_eIF5	242..392	CDD:211399	43/164 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346653
Domainoid	1	1.000	145	1.000	Domainoid score	I983
eggNOG	1	0.900	-	-		E1_COG1601
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49610
Inparanoid	1	1.050	258	1.000	Inparanoid score	I638
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54429
OrthoFinder	1	1.000	-	-		FOG0004050
OrthoInspector	1	1.000	-	-		oto99280
orthoMCL	1	0.900	-	-		OOG6_101859
Panther	1	1.100	-	-	LDO	PTHR23001
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R597
SonicParanoid	1	1.000	-	-		X2797
TreeFam	1	0.960	-	-
	15	14.790