DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF5 and AT1G36730

DIOPT Version :9

Sequence 1:	NP_573098.1	Gene:	eIF5 / 32566	FlyBaseID:	FBgn0030719	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_174877.1	Gene:	AT1G36730 / 840582	AraportID:	AT1G36730	Length:	439	Species:	Arabidopsis thaliana

Alignment Length:	465	Identity:	159/465 - (34%)
Similarity:	231/465 - (49%)	Gaps:	73/465 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATVNV---NRSVTDIFYRYKMPRLQAKVEGKGNGIKTVLVNMAEVARAIGRPATYPTKYFGCEL 62
            ||..|:   ||.  |.||||||||:..|:||:||||||.:|||.|:|:|:||||.|.||||||||
plant     1 MALQNIGASNRD--DAFYRYKMPRMMTKIEGRGNGIKTNVVNMVEIAKALGRPAAYTTKYFGCEL 63

  Fly    63 GAQTLFDHKNERFVVNGSHDVNKLQDLLDGFIRKFVLCPECDNPETNLTVSAKNQTISQSCKACG 127
            |||:.||.||...:|||:||.:||..||:.||:|:|.|..|.||||.:.:: |.|.:...|.|||
plant    64 GAQSKFDEKNGTSLVNGAHDTSKLAGLLENFIKKYVQCYGCGNPETEILIT-KTQMLQLKCAACG 127

  Fly   128 FHGLLKVNHKVNTFIVKNPPSLNPA---------AQGSSLTEG-------KRSRKQKQKNDNADG 176
            |...:.:..|:.:||:||||....:         |:...|.||       ::.:|:......|..
plant   128 FLSDVDMRDKLTSFILKNPPEQKKSSKDKKSMRRAEKERLREGEAADEEMRKLKKEAASKKKAAT 192

  Fly   177 SMTNNSLANNSGGESDGGNGTNQASQTEAEISAAIPEKTAKDDDDEGWSVDVSKEAIRARLQDLT 241
            :.|:....:.....|...:.:::..|.::|          :||||..|..|.|:||...|:::..
plant   193 TGTSKDKVSKKKDHSPPRSLSDENDQADSE----------EDDDDVQWQTDTSREAAEKRMKEQL 247

  Fly   242 DG--AKGMTISDDYDKTEKERIDIFYELVKDKRDKKQLDDVQTHKELVIEAERLDIINKAPLVL- 303
            ..  |:.:.:|...:|.....:....|.|.:..:.|..::  .|::||.|.:.|.....:|..|
plant   248 SAVTAEMVMLSTVEEKKPVAEVKKAPEQVHENGNSKIPEN--AHEKLVNEIKELLSSGSSPTQLK 310

  Fly   304 -------------AELLFT-------ENIIKDVQKNRPLLLRFTLNNPK----AQRYLIGGVEQT 344
                         .:.||:       :...|:|.|.:..||...:...:    ||..|:.|:|..
plant   311 TALASNSANPQEKMDALFSALFGGTGKGFAKEVIKKKKYLLALMMMQEEAGAPAQMGLLNGIESF 375

  Fly   345 VELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQK-VSKRHVSKNIAAEIHEKAMPFVLWLKNA 408
            ..........:||.:.|..||.|||||.||:||..| |....|.||:.        ||:.||:||
plant   376 CMKASAEAAKEVALVIKGLYDEDILDEDVIVEWYNKGVKSSPVLKNVT--------PFIEWLQNA 432

  Fly   409 EEESSESEEE 418
            |   ||||||
plant   433 E---SESEEE 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF5	NP_573098.1	eIF-5_eIF-2B	10..127	CDD:280114	67/116 (58%)
eIF5	NP_573098.1	W2_eIF5	254..408	CDD:211399	46/179 (26%)
AT1G36730	NP_174877.1	eIF2B_5	15..128	CDD:214764	67/113 (59%)
AT1G36730	NP_174877.1	W2_eIF5	286..437	CDD:211399	47/163 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	152	1.000	Domainoid score	I1380
eggNOG	1	0.900	-	-		E1_COG1601
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	222	1.000	Inparanoid score	I1196
OMA	1	1.010	-	-		QHG54429
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004050
OrthoInspector	1	1.000	-	-		otm3079
orthoMCL	1	0.900	-	-		OOG6_101859
Panther	1	1.100	-	-	LDO	PTHR23001
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2797
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830