Protein Alignment eIF5 and tif5

DIOPT Version :10

• Sequence 1: NP_573098.1
• Gene: eIF5 / 32566
• FlyBaseID: FBgn0030719
• Length: 464
• Species: Drosophila melanogaster
• Sequence 2: NP_592976.1
• Gene: tif5 / 2541629
• PomBaseID: SPAC2F7.05C
• Length: 395
• Species: Schizosaccharomyces pombe
• Alignment Length: 432
• Identity: 172/432 - (39%)
• Similarity: 261/432 - (60%)
• Gaps: 44/432 - (10%)

  Fly     1 MATVNVNRSVTDIFYRYKMPRLQAKVEGKGNGIKTVLVNMAEVARAIGRPATYPTKYFGCELGAQ 65
            |||:|:.|.|.|.||||:||:||:|:||||||||||:.||:::|:|:|||..|.||:||.|||||
pombe     1 MATINIRRDVKDSFYRYRMPKLQSKIEGKGNGIKTVIPNMSDIAKALGRPPLYVTKFFGFELGAQ 65

  Fly    66 TLFDHKNERFVVNGSHDVNKLQDLLDGFIRKFVLCPECDNPETNLTVSAKNQTISQSCKACGFHG 130
            |......:|::|||:||..|||||||.|||:||||..|.||||.|:::.|:||||..|||||:.|
pombe    66 TTIIADMDRYIVNGAHDAGKLQDLLDVFIRRFVLCASCQNPETELSINKKDQTISYDCKACGYRG 130

  Fly   131 LLKVNHKVNTFIVKNPPSLNPAAQGSSLTEGKRSRKQKQKNDNADGSMTNNSLANNSGGESDGGN 195
            ::...||:...||||||:            .|:|.|.|:.:..|:              |.||..
pombe   131 VIDGRHKLTGVIVKNPPA------------KKKSHKHKRDSPVAE--------------EEDGAE 169

  Fly   196 G--TNQASQTEAEISAAIPEKTAKDDDDEGWSVDVSKEAIRARLQDLTDGAK-GMTISD---DYD 254
            .  |.:..|..||:      .||:..:||.|:||.|:||:|||:|:|....| .:|:||   |.:
pombe   170 DELTRRIRQEAAEL------PTAEVVNDEDWAVDTSEEAVRARVQELEGNMKDSLTLSDLRGDEE 228

  Fly   255 KTEKERIDIFYELVKDKRDKKQLDDVQTHKELVIEAERLDIINKAPLVLAELLFTENIIKDVQKN 319
            :.|..|.|.|.|.::|  :...:.||:.:|::  :.|.:...:||.:||.:.:.|...:.:.:|:
pombe   229 EAESSRYDQFGEWLED--NYPGVSDVEIYKKM--KEENIHHKSKAIVVLVQCIITSPYVGEFEKH 289

  Fly   320 RPLLLRFTLNNPKAQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKR 384
            ..|..:....: |.:|.|:||.|:.:|..:.:.:..|..:....|..|::.:.:..:|..|.||:
pombe   290 GALFKKLCTTD-KHERALLGGFERLMENTELVHIDVVPKVLLEIYQNDLVSDDMFEKWGAKASKK 353

  Fly   385 HVSKNIAAEIHEKAMPFVLWLKNAEEESSESEEEEDDESEED 426
            :||:..:.:|||.|.||:.||..|.:| ||||:||::|.::|
pombe   354 YVSRETSKKIHEAAEPFLTWLAEASDE-SESEDEEEEEEDDD 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF5	NP_573098.1	eIF-5_eIF-2B	10..129	CDD:426485	75/118 (64%)
		W2_eIF5	254..408	CDD:211399	41/153 (27%)
tif5	NP_592976.1	eIF-5_eIF-2B	9..129	CDD:426485	75/119 (63%)
		W2_eIF5	228..374	CDD:211399	39/150 (26%)