DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF5 and SPAC2F7.05c

DIOPT Version :9

Sequence 1:	NP_573098.1	Gene:	eIF5 / 32566	FlyBaseID:	FBgn0030719	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_592976.1	Gene:	SPAC2F7.05c / 2541629	PomBaseID:	SPAC2F7.05c	Length:	395	Species:	Schizosaccharomyces pombe

Alignment Length:	432	Identity:	172/432 - (39%)
Similarity:	261/432 - (60%)	Gaps:	44/432 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATVNVNRSVTDIFYRYKMPRLQAKVEGKGNGIKTVLVNMAEVARAIGRPATYPTKYFGCELGAQ 65
            |||:|:.|.|.|.||||:||:||:|:||||||||||:.||:::|:|:|||..|.||:||.|||||
pombe     1 MATINIRRDVKDSFYRYRMPKLQSKIEGKGNGIKTVIPNMSDIAKALGRPPLYVTKFFGFELGAQ 65

  Fly    66 TLFDHKNERFVVNGSHDVNKLQDLLDGFIRKFVLCPECDNPETNLTVSAKNQTISQSCKACGFHG 130
            |......:|::|||:||..|||||||.|||:||||..|.||||.|:::.|:||||..|||||:.|
pombe    66 TTIIADMDRYIVNGAHDAGKLQDLLDVFIRRFVLCASCQNPETELSINKKDQTISYDCKACGYRG 130

  Fly   131 LLKVNHKVNTFIVKNPPSLNPAAQGSSLTEGKRSRKQKQKNDNADGSMTNNSLANNSGGESDGGN 195
            ::...||:...||||||:            .|:|.|.|:.:..|:              |.||..
pombe   131 VIDGRHKLTGVIVKNPPA------------KKKSHKHKRDSPVAE--------------EEDGAE 169

  Fly   196 G--TNQASQTEAEISAAIPEKTAKDDDDEGWSVDVSKEAIRARLQDLTDGAK-GMTISD---DYD 254
            .  |.:..|..||:      .||:..:||.|:||.|:||:|||:|:|....| .:|:||   |.:
pombe   170 DELTRRIRQEAAEL------PTAEVVNDEDWAVDTSEEAVRARVQELEGNMKDSLTLSDLRGDEE 228

  Fly   255 KTEKERIDIFYELVKDKRDKKQLDDVQTHKELVIEAERLDIINKAPLVLAELLFTENIIKDVQKN 319
            :.|..|.|.|.|.::|  :...:.||:.:|::  :.|.:...:||.:||.:.:.|...:.:.:|:
pombe   229 EAESSRYDQFGEWLED--NYPGVSDVEIYKKM--KEENIHHKSKAIVVLVQCIITSPYVGEFEKH 289

  Fly   320 RPLLLRFTLNNPKAQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKR 384
            ..|..:....: |.:|.|:||.|:.:|..:.:.:..|..:....|..|::.:.:..:|..|.||:
pombe   290 GALFKKLCTTD-KHERALLGGFERLMENTELVHIDVVPKVLLEIYQNDLVSDDMFEKWGAKASKK 353

  Fly   385 HVSKNIAAEIHEKAMPFVLWLKNAEEESSESEEEEDDESEED 426
            :||:..:.:|||.|.||:.||..|.:| ||||:||::|.::|
pombe   354 YVSRETSKKIHEAAEPFLTWLAEASDE-SESEDEEEEEEDDD 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF5	NP_573098.1	eIF-5_eIF-2B	10..127	CDD:280114	73/116 (63%)
eIF5	NP_573098.1	W2_eIF5	254..408	CDD:211399	41/153 (27%)
SPAC2F7.05c	NP_592976.1	eIF-5_eIF-2B	9..129	CDD:280114	75/119 (63%)
SPAC2F7.05c	NP_592976.1	W2_eIF5	228..374	CDD:211399	39/150 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	168	1.000	Domainoid score	I919
eggNOG	1	0.900	-	-		E1_COG1601
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49610
Inparanoid	1	1.050	300	1.000	Inparanoid score	I604
OMA	1	1.010	-	-		QHG54429
OrthoFinder	1	1.000	-	-		FOG0004050
OrthoInspector	1	1.000	-	-		oto100850
orthoMCL	1	0.900	-	-		OOG6_101859
Panther	1	1.100	-	-	LDO	PTHR23001
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R597
SonicParanoid	1	1.000	-	-		X2797
TreeFam	1	0.960	-	-
	14	13.860