DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF5 and Eif5

DIOPT Version :9

Sequence 1:	NP_573098.1	Gene:	eIF5 / 32566	FlyBaseID:	FBgn0030719	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_775539.1	Gene:	Eif5 / 217869	MGIID:	95309	Length:	429	Species:	Mus musculus

Alignment Length:	469	Identity:	233/469 - (49%)
Similarity:	315/469 - (67%)	Gaps:	48/469 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TVNVNRSVTDIFYRYKMPRLQAKVEGKGNGIKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTL 67
            :|||||||:|.|||||||||.|||||||||||||:|||.:||:|:.||.|||||||||||||||.
Mouse     2 SVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQ 66

  Fly    68 FDHKNERFVVNGSHDVNKLQDLLDGFIRKFVLCPECDNPETNLTVSAKNQTISQSCKACGFHGLL 132
            ||.||:|::|||||:.|||||:|||||:||||||||:||||:|.|:.|.|||..||||||:.|:|
Mouse    67 FDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131

  Fly   133 KVNHKVNTFIVKNPPSLNPAAQGSSLTEGKRSRKQKQKNDNADGSMTNNSLANNSGGESDGGNGT 197
            ..:||:.|||:||||      :.|.:..||:.:::|                |..|  .|..||:
Mouse   132 DTHHKLCTFILKNPP------ENSDIGTGKKEKEKK----------------NRKG--KDKENGS 172

  Fly   198 NQASQTEA-----EISAAIPEKTAKDDDDEGWSVDVSKEAIRARLQDLTDGAKGMTISDDYDKTE 257
            ...|:|..     |||   |....::::|:.|..|.::||.|.|:.:::|.|||:|:|||.::|.
Mouse   173 VSTSETPPPPPPNEIS---PPHAVEEEEDDDWGEDTTEEAQRRRMDEISDHAKGLTLSDDLERTV 234

  Fly   258 KERIDIFYELVKDKRDKKQLDDVQTHKELVIEAERLDIINKAPLVLAELLFTENIIKDVQKNRPL 322
            :||::|.::.||.|:::..:|  .:.||:|.||||||:....||||.|:||.|.|.:.::|.|..
Mouse   235 EERVNILFDFVKKKKEEGIID--SSDKEIVAEAERLDVKAMGPLVLTEVLFDEKIREQIKKYRRH 297

  Fly   323 LLRFTLNNPKAQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKRHVS 387
            .|||..||.||||||:.|:|..|.:|:..|:||:..|.|..||.|:|:|.||:.|::|.||::||
Mouse   298 FLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVS 362

  Fly   388 KNIAAEIHEKAMPFVLWLKNAEEESSESEEEEDDESEEDNYVSSAGQRGGQRVVQRGIPR--AVA 450
            |.:|.||..||.||:.|||.||||||..|||::||:.|..|..:|           .:|:  .|.
Mouse   363 KELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKTA-----------SVPKVETVK 416

  Fly   451 GDEDDEDDVNIDDI 464
            .|..| ||::||.|
Mouse   417 SDNKD-DDIDIDAI 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF5	NP_573098.1	eIF-5_eIF-2B	10..127	CDD:280114	89/116 (77%)
eIF5	NP_573098.1	W2_eIF5	254..408	CDD:211399	72/153 (47%)
Eif5	NP_775539.1	eIF-5_eIF-2B	9..128	CDD:396445	91/118 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..216		26/99 (26%)
		W2_eIF5	231..383	CDD:211399	72/153 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850414
Domainoid	1	1.000	203	1.000	Domainoid score	I2969
eggNOG	1	0.900	-	-		E1_COG1601
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49610
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1669
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54429
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004050
OrthoInspector	1	1.000	-	-		oto92740
orthoMCL	1	0.900	-	-		OOG6_101859
Panther	1	1.100	-	-	LDO	PTHR23001
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R597
SonicParanoid	1	1.000	-	-		X2797
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790