DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF5 and EIF5

DIOPT Version :9

Sequence 1:	NP_573098.1	Gene:	eIF5 / 32566	FlyBaseID:	FBgn0030719	Length:	464	Species:	Drosophila melanogaster
Sequence 2:	NP_001960.2	Gene:	EIF5 / 1983	HGNCID:	3299	Length:	431	Species:	Homo sapiens

Alignment Length:	470	Identity:	232/470 - (49%)
Similarity:	314/470 - (66%)	Gaps:	48/470 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TVNVNRSVTDIFYRYKMPRLQAKVEGKGNGIKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTL 67
            :|||||||:|.|||||||||.|||||||||||||:|||.:||:|:.||.|||||||||||||||.
Human     2 SVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQ 66

  Fly    68 FDHKNERFVVNGSHDVNKLQDLLDGFIRKFVLCPECDNPETNLTVSAKNQTISQSCKACGFHGLL 132
            ||.||:|::|||||:.|||||:|||||:||||||||:||||:|.|:.|.|||..||||||:.|:|
Human    67 FDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131

  Fly   133 KVNHKVNTFIVKNPPSLNPAAQGSSLTEGKRSRKQKQKNDNADGSMTNNSLANNSGGESDGGNGT 197
            ..:||:.|||:||||..:.:..|....| |::||.|.|.                       ||:
Human   132 DTHHKLCTFILKNPPENSDSGTGKKEKE-KKNRKGKDKE-----------------------NGS 172

  Fly   198 NQASQTEA------EISAAIPEKTAKDDDDEGWSVDVSKEAIRARLQDLTDGAKGMTISDDYDKT 256
            ..:|:|..      ||:.  |..|.::::|:.|..|.::||.|.|:.:::|.||.:|:|||.::|
Human   173 VSSSETPPPPPPPNEINP--PPHTMEEEEDDDWGEDTTEEAQRRRMDEISDHAKVLTLSDDLERT 235

  Fly   257 EKERIDIFYELVKDKRDKKQLDDVQTHKELVIEAERLDIINKAPLVLAELLFTENIIKDVQKNRP 321
            .:||::|.::.||.|:::..:|  .:.||:|.||||||:....||||.|:||.|.|.:.::|.|.
Human   236 IEERVNILFDFVKKKKEEGVID--SSDKEIVAEAERLDVKAMGPLVLTEVLFNEKIREQIKKYRR 298

  Fly   322 LLLRFTLNNPKAQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKRHV 386
            ..|||..||.||||||:.|:|..|.:|:..|:||:..|.|..||.|:|:|.||:.|::|.||::|
Human   299 HFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYV 363

  Fly   387 SKNIAAEIHEKAMPFVLWLKNAEEESSESEEEEDDESEEDNYVSSAGQRGGQRVVQRGIPR--AV 449
            ||.:|.||..||.||:.|||.||||||..|||::||:.|..|..:|           .:|:  .|
Human   364 SKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKAA-----------SVPKVETV 417

  Fly   450 AGDEDDEDDVNIDDI 464
            ..|..| ||::||.|
Human   418 KSDNKD-DDIDIDAI 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF5	NP_573098.1	eIF-5_eIF-2B	10..127	CDD:280114	89/116 (77%)
eIF5	NP_573098.1	W2_eIF5	254..408	CDD:211399	72/153 (47%)
EIF5	NP_001960.2	eIF-5_eIF-2B	9..128	CDD:280114	91/118 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..216		25/98 (26%)
		W2_eIF5	233..385	CDD:211399	72/153 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160045
Domainoid	1	1.000	203	1.000	Domainoid score	I2977
eggNOG	1	0.900	-	-		E1_COG1601
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49610
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1711
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54429
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004050
OrthoInspector	1	1.000	-	-		oto89176
orthoMCL	1	0.900	-	-		OOG6_101859
Panther	1	1.100	-	-	LDO	PTHR23001
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R597
SonicParanoid	1	1.000	-	-		X2797
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790