Protein Alignment eIF5 and C37C3.2

DIOPT Version :9

• Sequence 1: NP_573098.1
• Gene: eIF5 / 32566
• FlyBaseID: FBgn0030719
• Length: 464
• Species: Drosophila melanogaster
• Sequence 2: NP_001370553.1
• Gene: C37C3.2 / 179165
• WormBaseID: WBGene00016496
• Length: 436
• Species: Caenorhabditis elegans
• Alignment Length: 475
• Identity: 201/475 - (42%)
• Similarity: 283/475 - (59%)
• Gaps: 55/475 - (11%)

  Fly     4 VNVNRSVTDIFYRYKMPRLQAKVEGKGNGIKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTLF 68
            :||||:|.|.|||||||:|.|||||||||||||:.||:|:|:|:.||..||||||||||||||.|
 Worm     3 LNVNRAVADPFYRYKMPKLSAKVEGKGNGIKTVISNMSEIAKALERPPMYPTKYFGCELGAQTNF 67

  Fly    69 DHKNERFVVNGSHDVNKLQDLLDGFIRKFVLCPECDNPETNLTVSAKNQTISQSCKACGFHGLLK 133
            |.||||::|||.||.|||||:|||||:|||||..|:||||.|.|...|  |...|||||....:.
 Worm    68 DAKNERYIVNGEHDANKLQDILDGFIKKFVLCKSCENPETQLFVRKNN--IKSKCKACGCSFDID 130

  Fly   134 VNHKVNTFIVKNPPSLNPAAQGSSLTEGKRSRKQKQKNDNADGSMTNNSLANNSGGESDGGNGTN 198
            :.||::|||:||||.::....           |.:|||    |..|               :|.:
 Worm   131 LKHKLSTFIMKNPPKIDVDFS-----------KAEQKN----GKKT---------------SGAD 165

  Fly   199 QASQTEAEISAAIPEKTAKDDDDEGWSVD-VSKEAIRARLQDLTDGAKGMTISDDYDKTEKERID 262
            .|:...|:|.....:.::.||||:.|..: |....:      |:.|...:.:..|.:|:|::|:|
 Worm   166 AAAAVAADIIHNSDKGSSNDDDDDDWEPEPVEPNGM------LSAGMGKLVLDKDLEKSEEQRLD 224

  Fly   263 IFYELVKDKRDKKQLDDVQTHKELVIEAERLDIINKAPLVLAELLFTENII--KDVQKNRPLLLR 325
            :.:......:::.::.|.:....|..|||||::..||.|:||.:...|.:|  |.:.|:|.||||
 Worm   225 MLHTFFLKAKEEDRISDAKGQTALRDEAERLELKQKASLLLANVFLDEKVITDKQISKHRNLLLR 289

  Fly   326 FTLNNPKAQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKRHVSKNI 390
            ||||:.||||||:|||||.:..|:..|:||.|.|.|..||.|:.:|..::.|.:|.|.::|||:.
 Worm   290 FTLNDKKAQRYLLGGVEQVIHKHEAELLSKSAHIIKSLYDEDVCEEDSLISWGEKPSSKYVSKSF 354

  Fly   391 AAEIHEKAMPFVLWLKNAEEESSESEEEEDDE------SEEDNYVSSAGQRGGQRVVQRGIP--- 446
            |.:|.|.:.|.:.|||.|||   |:|||.|||      .:|..::....::..:...|:...
 Worm   355 AKKIIENSQPVLNWLKEAEE---ETEEESDDEIAFGGDVKESEFLRQQKEKAAREAQQKSAKATN 416

  Fly   447 --RAVAGDEDDEDDVNIDDI 464
              .|.|...:||:|::||||
 Worm   417 GNAAAASGANDEEDLDIDDI 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF5	NP_573098.1	eIF-5_eIF-2B	10..127	CDD:280114	82/116 (71%)
		W2_eIF5	254..408	CDD:211399	64/155 (41%)
C37C3.2	NP_001370553.1	eIF-5_eIF-2B	9..126	CDD:396445	84/118 (71%)
		W2_eIF5	216..370	CDD:211399	62/153 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167556
Domainoid	1	1.000	181	1.000	Domainoid score	I2075
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49610
Inparanoid	1	1.050	355	1.000	Inparanoid score	I1310
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54429
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004050
OrthoInspector	1	1.000	-	-		oto19933
orthoMCL	1	0.900	-	-		OOG6_101859
Panther	1	1.100	-	-	LDO	PTHR23001
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R597
SonicParanoid	1	1.000	-	-		X2797
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.930