Protein Alignment eIF5 and Eif5

DIOPT Version :10

• Sequence 1: NP_573098.1
• Gene: eIF5 / 32566
• FlyBaseID: FBgn0030719
• Length: 464
• Species: Drosophila melanogaster
• Sequence 2: NP_001316808.1
• Gene: Eif5 / 108348073
• RGDID: 619861
• Length: 429
• Species: Rattus norvegicus
• Alignment Length: 469
• Identity: 232/469 - (49%)
• Similarity: 315/469 - (67%)
• Gaps: 48/469 - (10%)

  Fly     3 TVNVNRSVTDIFYRYKMPRLQAKVEGKGNGIKTVLVNMAEVARAIGRPATYPTKYFGCELGAQTL 67
            :|||||||:|.|||||||||.|||||||||||||:|||.:||:|:.||.|||||||||||||||.
  Rat     2 SVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQ 66

  Fly    68 FDHKNERFVVNGSHDVNKLQDLLDGFIRKFVLCPECDNPETNLTVSAKNQTISQSCKACGFHGLL 132
            ||.||:|::|||||:.|||||:|||||:||||||||:||||:|.|:.|.|||..||||||:.|:|
  Rat    67 FDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGML 131

  Fly   133 KVNHKVNTFIVKNPPSLNPAAQGSSLTEGKRSRKQKQKNDNADGSMTNNSLANNSGGESDGGNGT 197
            ..:||:.|||:||||      :.|.:..||:.:::|                |..|  .|..||:
  Rat   132 DTHHKLCTFILKNPP------ENSDIGTGKKEKEKK----------------NRKG--KDKENGS 172

  Fly   198 NQASQTEA-----EISAAIPEKTAKDDDDEGWSVDVSKEAIRARLQDLTDGAKGMTISDDYDKTE 257
            ...|:|..     |||   |....::::|:.|..|.::||.|.|:.:::|.|||:|:|||.::|.
  Rat   173 VSTSETPPPPPPNEIS---PPHAVEEEEDDDWGEDTTEEAQRRRMDEISDHAKGLTLSDDLERTV 234

  Fly   258 KERIDIFYELVKDKRDKKQLDDVQTHKELVIEAERLDIINKAPLVLAELLFTENIIKDVQKNRPL 322
            :||::|.::.||.|:::..:|  .:.|::|.||||||:....||||.|:||.|.|.:.::|.|..
  Rat   235 EERVNILFDFVKKKKEEGIID--SSDKDIVAEAERLDVKAMGPLVLTEVLFDEKIREQIKKYRRH 297

  Fly   323 LLRFTLNNPKAQRYLIGGVEQTVELHKGILMSKVAGIFKLFYDLDILDEAVILEWAQKVSKRHVS 387
            .|||..||.||||||:.|:|..|.:|:..|:||:..|.|..||.|:|:|.||:.|::|.||::||
  Rat   298 FLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVS 362

  Fly   388 KNIAAEIHEKAMPFVLWLKNAEEESSESEEEEDDESEEDNYVSSAGQRGGQRVVQRGIPR--AVA 450
            |.:|.||..||.||:.|||.||||||..|||::||:.|..|..:|           .:|:  .|.
  Rat   363 KELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKTA-----------SVPKVETVK 416

  Fly   451 GDEDDEDDVNIDDI 464
            .|..| ||::||.|
  Rat   417 SDNKD-DDIDIDAI 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF5	NP_573098.1	eIF-5_eIF-2B	10..129	CDD:426485	91/118 (77%)
		W2_eIF5	254..408	CDD:211399	71/153 (46%)
Eif5	NP_001316808.1	eIF-5_eIF-2B	9..128	CDD:426485	91/118 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	143..216		26/99 (26%)
		W2_eIF5	231..383	CDD:211399	71/153 (46%)