DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc25A46a and slc25a46

DIOPT Version :9

Sequence 1:	NP_573096.1	Gene:	Slc25A46a / 32564	FlyBaseID:	FBgn0030717	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001002558.1	Gene:	slc25a46 / 436831	ZFINID:	ZDB-GENE-040718-296	Length:	405	Species:	Danio rerio

Alignment Length:	322	Identity:	125/322 - (38%)
Similarity:	193/322 - (59%)	Gaps:	18/322 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 GVQWVSLVTENLLSHPFVVLRRQCQVYNASRRYHLHPFQLLPSIVHLHRRQGLTTLWKGVGSCLL 126
            |:...||.|||:|:||.:|.||||||...:|.|||.|...:..:.::.:.||...||||:||..:
Zfish    88 GIGLASLFTENVLAHPCIVFRRQCQVNYHARCYHLSPMTAISVMYNVTKTQGPKALWKGMGSTFV 152

  Fly   127 VRGMTLAIDDFISKVTSWPKDVNSRTTLKRFGQHLLLKCISIGLVVPFYAASLVETVQSDIASEK 191
            |:|:||..:..||:.|..|::::.:...|:...||:||.::..:.:|||:|||:|||||:|..:.
Zfish   153 VQGVTLGTEGIISECTPLPRELSHKWNPKQVVGHLVLKGLTYVVAMPFYSASLIETVQSEIIRDN 217

  Fly   192 PGLFDVFREGSLRLFYWSSPQKGRMLPAWALIGPSVSFGITKYLFNLVIRGVSSRIMRLRI---- 252
            ||:.|..:||..|:.....|...|:||.|.|:.|:|..||..|:       :||.|.||.:
Zfish   218 PGILDCVKEGLGRVMGMGIPHSKRLLPLWNLVLPTVLHGILHYI-------ISSSIQRLVLYLLR 275

  Fly   253 -------KNSQDGQGGKYQDTTLEQQNADIYASLIAIITTEVMFFPFETILHRLQLQGTRTIIDN 310
                   |:|..|.|.....:.|:....::.||..|.:..:|:.||.||:||||.:|||||||||
Zfish   276 RRNNGSPKHSSPGSGMDTVQSMLDAYFPELMASFAASLCADVLLFPLETVLHRLHIQGTRTIIDN 340

  Fly   311 LDNGYDVVPILTNYQGVVDCYQTTIVSEGVSGLYKGFGAMILQFAAHVAVIKLTKWVVNQIV 372
            .|.|::|:||.|.|:|:.||.......||..|.|||||::::|::.|..|:::||.:.:.::
Zfish   341 TDLGFEVLPINTQYEGMRDCINAIRREEGTMGFYKGFGSIVVQYSLHATVLQITKMIYSTLL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc25A46a	NP_573096.1	Mito_carr	277..360	CDD:278578	41/82 (50%)
slc25a46	NP_001002558.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		Solcar 1	80..171		36/82 (44%)
		Solcar 2	299..401		44/101 (44%)
		Mito_carr	305..390	CDD:278578	41/84 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589812
Domainoid	1	1.000	149	1.000	Domainoid score	I4387
eggNOG	1	0.900	-	-		E1_KOG2954
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14518
Inparanoid	1	1.050	244	1.000	Inparanoid score	I3278
OMA	1	1.010	-	-		QHG48591
OrthoDB	1	1.010	-	-		D283554at33208
OrthoFinder	1	1.000	-	-		FOG0005765
OrthoInspector	1	1.000	-	-		otm26077
orthoMCL	1	0.900	-	-		OOG6_107935
Panther	1	1.100	-	-	LDO	PTHR21252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4376
SonicParanoid	1	1.000	-	-		X4154
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800