DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc25A46a and Slc25A46b

DIOPT Version :9

Sequence 1:	NP_573096.1	Gene:	Slc25A46a / 32564	FlyBaseID:	FBgn0030717	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_609864.1	Gene:	Slc25A46b / 35081	FlyBaseID:	FBgn0032664	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	455	Identity:	263/455 - (57%)
Similarity:	319/455 - (70%)	Gaps:	46/455 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EYSSLKFQAEYETHDDHLGKEHRTGDRDQHLPVTYGPSKHLGSSLEEREKAIVD----------- 59
            |...||...:.|..|.:|.||.:|    .:|...:.|...|.:|::.|||:||:
  Fly     2 ECQELKLVTDKELIDKNLEKEEQT----CNLVPAWSPRNPLENSIDCREKSIVENINADQDAIAK 62

  Fly    60 ----------------------------VVGVQWVSLVTENLLSHPFVVLRRQCQVYNASRRYHL 96
                                        ||||.||||:||::|||||:|||.||||||||:.|||
  Fly    63 IQYLSSEHAKLDKYLDNQEQDESLRKYLVVGVHWVSLLTEHVLSHPFLVLRWQCQVYNASKCYHL 127

  Fly    97 HPFQLLPSIVHLHRRQGLTTLWKGVGSCLLVRGMTLAIDDFISKVTSWPKDVNSRTTLKRFGQHL 161
            |||.|||.||||||||||||||||:|||||||||:.||||.|||::||||:::|||||||||||:
  Fly   128 HPFTLLPCIVHLHRRQGLTTLWKGMGSCLLVRGMSCAIDDVISKLSSWPKELDSRTTLKRFGQHV 192

  Fly   162 LLKCISIGLVVPFYAASLVETVQSDIASEKPGLFDVFREGSLRLFYWSSPQKGRMLPAWALIGPS 226
            |||.:||.||:||:..|||:||||.|||:|.|||||.|||..|:|.|.|||..||||.|||||||
  Fly   193 LLKSVSIALVLPFHTVSLVKTVQSGIASDKTGLFDVLREGGARIFSWRSPQNTRMLPTWALIGPS 257

  Fly   227 VSFGITKYLFNLVIRGVSSRIMRLRIKNSQDGQGGKYQDTTLEQQNADIYASLIAIITTEVMFFP 291
            :|.|||||||||:|.|||:|:|:.|:   .:.:..|..|..||.|||..||.|||::||||:|||
  Fly   258 ISIGITKYLFNLLIHGVSTRMMQRRM---LENRCEKNPDNKLENQNAKTYAGLIAMLTTEVVFFP 319

  Fly   292 FETILHRLQLQGTRTIIDNLDNGYDVVPILTNYQGVVDCYQTTIVSEGVSGLYKGFGAMILQFAA 356
            .|||||||:||||||||||||.||.|||:||:|:|:.|||:.|::|||.:|||||||||||||.|
  Fly   320 LETILHRLELQGTRTIIDNLDTGYSVVPVLTDYRGLFDCYRVTVISEGAAGLYKGFGAMILQFVA 384

  Fly   357 HVAVIKLTKWVVNQIVEVISNRPPQRIVNYYNLDENACNSRSTTLSPSLSSTEMGEISLGQNSQD 421
            .||:|||.||..:||...|.|||..|.|..||.|..:||..|||.|||:||.::...|||:.|.|
  Fly   385 QVAIIKLAKWTADQIAAGILNRPTSRTVQPYNFDSLSCNKSSTTKSPSISSIDVELTSLGKYSLD 449

Fly 422 421
Fly 450 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc25A46a	NP_573096.1	Mito_carr	277..360	CDD:278578	61/82 (74%)
Slc25A46b	NP_609864.1	Mito_carr	305..388	CDD:278578	61/82 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460438
Domainoid	1	1.000	149	1.000	Domainoid score	I4387
eggNOG	1	0.900	-	-		E1_KOG2954
Homologene	1	1.000	-	-		H14518
Inparanoid	1	1.050	244	1.000	Inparanoid score	I3278
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D283554at33208
OrthoFinder	1	1.000	-	-		FOG0005765
OrthoInspector	1	1.000	-	-		otm26077
orthoMCL	1	0.900	-	-		OOG6_107935
Panther	1	1.100	-	-	P	PTHR21252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4376
SonicParanoid	1	1.000	-	-		X4154
	13	12.830