DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc25A46a and slc-25A46

DIOPT Version :9

Sequence 1:	NP_573096.1	Gene:	Slc25A46a / 32564	FlyBaseID:	FBgn0030717	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_493364.1	Gene:	slc-25A46 / 173212	WormBaseID:	WBGene00012740	Length:	500	Species:	Caenorhabditis elegans

Alignment Length:	371	Identity:	108/371 - (29%)
Similarity:	182/371 - (49%)	Gaps:	34/371 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NEYSSLKFQ-----AEYETHDDHLGKEHRTGDRDQHLPVTYGPSKHLGSSLEEREKAIVDVVGVQ 64
            |::||...|     :.|..|..|...::       |.|   .|.|.....|......:.||
Worm    27 NDFSSSSHQLPSTASGYSEHSSHQNFQN-------HSP---PPGKATTDPLAGALLGLSDV---- 77

  Fly    65 WVSLVTENLLSHPFVVLRRQCQVYNASRRYHLHPFQLLPSIVHLHRRQGLTTLWKG-VGSCLLVR 128
                :|::|:|||..||||||||:..:...||.|..|:|.|.:...:||:.|.||| :||.:| .
Worm    78 ----ITKSLISHPCGVLRRQCQVHQFAGSLHLTPVTLIPVICNSVAKQGIQTFWKGAIGSSVL-W 137

  Fly   129 GMTLAIDDFISKVTSWPKDVNSRTTLKRFGQHLLLKCISIGLVVPFYAASLVETVQSD--IASEK 191
            |:|...:..:..:...|:......:.:::.:|::||.::...:.|||.:|.:|||:|:  |..|.
Worm   138 GLTNVTEIVLGDLMGLPRTFVVNGSAEKYWKHIVLKGVTFVTMTPFYISSFIETVRSESGIGGED 202

  Fly   192 PGLFDVFREG--SLRLFYWSSPQKGRMLPAWALIGPSVSFGITKYLFNLVIRGVSSRIMRLRIKN 254
            ..:.||..:|  .:|.|..|.....|......|..|:..|.:..|:....:.....|:.:..:..
Worm   203 NKILDVLVKGVDRMRYFLTSGRDPSRRFSIIHLAIPTAGFQVGHYMLQTALYHQFFRMAKRYVNR 267

  Fly   255 SQDGQGGKYQDTTLEQQNADIYASLIAIITTEVMFFPFETILHRLQLQGTRTIIDNLDNGYDVVP 319
            ....:...|.| .|.|    ::|...:::.|:::.:|||||:||:.:|||||:|||:|.|...|.
Worm   268 KSPAEKTTYHD-FLPQ----MFAQTSSMVLTDLILYPFETIVHRMYIQGTRTLIDNMDTGLSAVS 327

  Fly   320 ILTNYQGVVDCYQTTIVSEGVSGLYKGFGAMILQFAAHVAVIKLTK 365
            :...|.|..||.:..:.:||...||.|.||::|:::.|..:.:|.:
Worm   328 MTVKYSGYFDCVRQVLETEGFWALYAGVGAVLLEYSLHQGLQQLVR 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc25A46a	NP_573096.1	Mito_carr	277..360	CDD:278578	33/82 (40%)
slc-25A46	NP_493364.1	Mito_carr	291..385	CDD:278578	33/83 (40%)
slc-25A46	NP_493364.1	L-asparaginase_like	<351..424	CDD:294148	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163477
Domainoid	1	1.000	93	1.000	Domainoid score	I4765
eggNOG	1	0.900	-	-		E1_KOG2954
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14518
Inparanoid	1	1.050	165	1.000	Inparanoid score	I2809
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48591
OrthoDB	1	1.010	-	-		D283554at33208
OrthoFinder	1	1.000	-	-		FOG0005765
OrthoInspector	1	1.000	-	-		otm14105
orthoMCL	1	0.900	-	-		OOG6_107935
Panther	1	1.100	-	-	LDO	PTHR21252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4376
SonicParanoid	1	1.000	-	-		X4154
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840