Protein Alignment Cep164 and CEP164

DIOPT Version :10

• Sequence 1: NP_573095.1
• Gene: Cep164 / 32563
• FlyBaseID: FBgn0030716
• Length: 1246
• Species: Drosophila melanogaster
• Sequence 2: XP_011540976.1
• Gene: CEP164 / 22897
• HGNCID: 29182
• Length: 2042
• Species: Homo sapiens
• Alignment Length: 1469
• Identity: 288/1469 - (19%)
• Similarity: 495/1469 - (33%)
• Gaps: 478/1469 - (32%)

  Fly    21 KSLPATPSSSSQGSSSVICEEVFDEACFPSSEEINEYASLIGIDPQKEPHLLYLAKEGLMAALPT 85
            :.|..||.|:.:||.||......:     |..::.|               |.|..:||..:
Human   713 RGLVDTPPSALRGSQSVSLGSSVE-----SGRQLGE---------------LMLPSQGLKTS--- 754

  Fly    86 DWKICYSEEKNGHYYHN----------TRTKESQWDHPLDAIYRDLVNQARQKPLDTGSVGDNDD 140
                .|::...|..|.:          ..|.|...:...:..........|...||.|::|.:
Human   755 ----AYTKGLLGSIYEDKTALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNLHLDIGALGGD-- 813

  Fly   141 LSQLDSGIRSMQ-------GIDDIPSPGPLPLNSLARKWSVASKASLFSSAKSRFLESGSKDMGR 198
             .:.:..:|:.|       .:|...:..|.|    .:..|..:.:||.|:.......||::.
Human   814 -FEYEESLRTSQPEEKKDVSLDSDAAGPPTP----CKPSSPGADSSLSSAVGKGRQGSGARP--- 870

  Fly   199 LHQLGF----EVTKSKPQI-------------------ANKPAPTSQMNGKTDRSEENEGGTKPS 240
                |.    |..||:|:|                   :.|.||...::...:.|...|...:|.
Human   871 ----GLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPK 931

  Fly   241 GTVSMFQK----AHRQFE-SDGYTSPSGVKGILRDSSITD--------------ISRRL---DRL 283
            ...|..::    |.::.| |:....|.     |.||..:|              ||..|   |.|
Human   932 KKASALEEGSSDASQELEISEHMKEPQ-----LSDSIASDPKSFHGLDFGFRSRISEHLLDVDVL 991

  Fly   284 EPTVEG-----------EDKKSVRFNLDQGQRGKSSPEETQSI-----------------KMTQA 320
            .|.:.|           |||...:.:.|:.|..:|...|..|:                 :::..
Human   992 SPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEESSLPALQMEGPDSAALPGLTRLSPP 1056

  Fly   321 YKQNEHSQSEDDD---EDVVVQGDDDDEDDDEDNDVIEDEDVDKD-----DREGALNP------- 370
            ....|.:||....   |:...||.:...:..|..::.||......     .||.|.:|
Human  1057 LPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKG 1121

  Fly   371 ----------WPDNDEAIYNRNPFLSDANKTIPKTIPEVVKISGSGDTVSDKTKDTDAPKLFYDD 425
                      .|..:||   .:|....|....|...|||            ::.:..||    .:
Human  1122 KEQHSQAEELGPGQEEA---EDPEEKVAVSPTPPVSPEV------------RSTEPVAP----PE 1167

  Fly   426 TDSDSKGSSVRSFIINKSEQDSSLLVGNNAFDLEELGRKHSYELEQLQLKSAQAPASDKSICS-T 489
            ..|::...::...:....|||...|:.:....:::|..|...|.|:..|:..|  ..::|:.| .
Human  1168 QLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQ--QKEQSLSSLR 1230

  Fly   490 SAFRANIADKEAQL-------------------QTDFEAIRRDHEAKLKRFRHEYDLRLTSHQHK 535
            ...:..|.::||::                   |.|.:.||.:.||.|::.|.|.:.:..:.:..
Human  1231 ERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERAS 1295

  Fly   536 LEE----------------------AFELQMEKYRVQLERQLQSKR----TLMATEHKSRMD--- 571
            ||:                      |.....||...||..||:.:|    ..:..||.:.::
Human  1296 LEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLC 1360

  Fly   572 -ALQANHEEILRDLEREL---------------------------------HGEEELLRR----- 597
             :|:|.|.|::..|::::                                 |....|||.
Human  1361 SSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEV 1425

  Fly   598 --EHSSRLSQMREKF------ARE-LDAEKQRFR--------------EKGEERLYEKVRCEK-R 638
              ||..||.:|:|:.      ||| .:||:::.|              ::..||..|.||.|: :
Human  1426 EGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHK 1490

  Fly   639 LLEDKYRCLKEKYVRLKTDVKLSLERRNRRREAQMAPQHNHTNSTKSTNSGTEMERSMERYYKPQ 703
            .|||..|..:|:..:|: |::|.||.|.:..:|::|.              .|::....|..|.|
Human  1491 RLEDLRRRHREQERKLQ-DLELDLETRAKDVKARLAL--------------LEVQEETARREKQQ 1540

  Fly   704 SGNSDNRSLSYSDQAIAGEAIVKPCPVPHKSQLTKSYNIRQL--QLQDDNTSI-SQSDTTLSNTY 765
            ..:...:....|::|.|....::.....|...|..:..:|::  :||.....: ||.|
Human  1541 LLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVD------- 1598

  Fly   766 NNGRYGPFLKSASGVLSARTASDNGNSSRDGVVAAVATQSNLERNNNS---------NQIKESTG 821
                   .|::.|..|....:|....:.:...:....|   :|.||.|         ..:::|.|
Human  1599 -------LLQAQSQQLQKHFSSLEAEAQKKQHLLREVT---VEENNASPHFEPDLHIEDLRKSLG 1653

  Fly   822 INRIVFSRTKSASTSRLNSDTSYKGERPCTPVENLRHQLQKLEALEDQFPENTLDAPYHLRYPFT 886
            .|     :||..|:|...|.                         ||.:    ||
Human  1654 TN-----QTKEVSSSLSQSK-------------------------EDLY----LD---------- 1674

  Fly   887 DISIKPNGVGSELEFFKHRIHLERDSVRRAKESLRTQRTNFRLRQ-----------REIGQQRKI 940
              |:..:.|.       |.:..|..::|.|||.|..|..:.|.||           .|:...:::
Human  1675 --SLSSHNVW-------HLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEV 1730

  Fly   941 TALSP-----KHSIDQLIQEEKELTEMEVNLHRTRSLLGEKIIRLRHLEQSLLRIYEKEKSILDL 1000
            ....|     :.....|.:|.:.|.||:..:.:..:||.:|..:|..||.||.    :|.|  |.
Human  1731 AKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLW----EEAS--DE 1789

  Fly  1001 GTMDDAAT-------LSD---LSSHSSSGFSSTDLASAADFHKKKDYYQQESNECI--------- 1046
            ||:..:.|       |||   |||.||..||.          ..:::::|:..:..
Human  1790 GTLGGSPTKKAVTFDLSDMDSLSSESSESFSP----------PHREWWRQQRIDSTPSLTSRKIH 1844

  Fly  1047 ---ENLEILNAEIREILDIFGQKQYQQQHDQTASGIPILSPRDLGWSQVLKHQHSGTQNFSLSDD 1108
               .:|..:::::..:|.|......|......||....|.|||...:....:..|..:..:||..
Human  1845 GLSHSLRQISSQLSSVLSILDSLNPQSPPPLLASMPAQLPPRDPKSTPTPTYYGSLARFSALSSA 1909

  Fly  1109 I--------EGGGAVHIPHSIPTLAD--RLETYR-----------------QLAAGRMQSSMGAA 1146
            .        :.|....:|.|:....|  .||.:|                 :...|.|.:|....
Human  1910 TPTSTQWAWDSGQGPRLPSSVAQTVDDFLLEKWRKYFPSGIPLLSNSPTPLESRLGYMSASEQLR 1974

  Fly  1147 ILTANTIVSQSPRAVNYT-TCLVERTRDLRNWLRQAKNE 1184
            :|..:.  ||.|.|.:.| ..::|..   |.||.:.||:
Human  1975 LLQHSH--SQVPEAGSTTFQGIIEAN---RRWLERVKND 2008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cep164	NP_573095.1	WW	83..113	CDD:459800	5/39 (13%)
		DUF5401	<498..>678	CDD:375164	63/290 (22%)
CEP164	XP_011540976.1	WW	59..89	CDD:238122
		PHA03307	823..>1190	CDD:223039	74/401 (18%)
		Smc	<1167..>1652	CDD:440809	101/518 (19%)