Protein Alignment mmd and ADAM7

DIOPT Version :10

• Sequence 1: NP_001285311.1
• Gene: mmd / 32561
• FlyBaseID: FBgn0259110
• Length: 1484
• Species: Drosophila melanogaster
• Sequence 2: NP_003808.2
• Gene: ADAM7 / 8756
• HGNCID: 214
• Length: 754
• Species: Homo sapiens
• Alignment Length: 844
• Identity: 217/844 - (25%)
• Similarity: 367/844 - (43%)
• Gaps: 157/844 - (18%)

  Fly    64 YYQIIYPVQLRHHEKMGISTREVSLPK--PGQRPRPHDDSGFNRGRTKKHFHRTSLLIKAFNHKF 126
            :..|:...|::....:|:..:::..||  |..:.|   |:|        |.|...:| |.:..:.
Human     7 FLMILLIPQVKEKFILGVEGQQLVRPKKLPLIQKR---DTG--------HTHDDDIL-KTYEEEL 59

  Fly   127 RLDLELN-----------SQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTVKDYPGASAAFH 180
            ..:::||           .:.|..|..:..|.:.|.....:...::||:|.|::.....::|:..
Human    60 LYEIKLNRKTLVLHLLRSREFLGSNYSETFYSMKGEAFTRHPQIMDHCFYQGSIVHEYDSAASIS 124

  Fly   181 TCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTK----ANKGCANSGNLDSWRLSRRT-- 239
            ||||:.|...|.::.::|.|....|  :..|::|:...:    ||..|.      ....:|:|
Human   125 TCNGLRGFFRINDQRYLIEPVKYSD--EGEHLVFKYNLRVPYGANYSCT------ELNFTRKTVP 181

  Fly   240 ----KHLSAGVAGVVEEILQAGVGRNKRDVREATKYIETAIIVDKAMFDKRNGSTRAEVIHDAIQ 300
                ....:.:.|:.:|                 ||:|..|:.|..:: :|||....::.:....
Human   182 GDNESEEDSKIKGIHDE-----------------KYVELFIVADDTVY-RRNGHPHNKLRNRIWG 228

  Fly   301 VANIADLYFRTLNTRVSVVYIETWGKNQAVIDGSKDISKAISNFNDYTSRNL-FQIERDTTQLLT 364
            :.|..::.::|||..|::|.||.| .::..|:...:|...:..|:.:..:.| .:.:.|...||:
Human   229 MVNFVNMIYKTLNIHVTLVGIEIW-THEDKIELYSNIETTLLRFSFWQEKILKTRKDFDHVVLLS 292

  Fly   365 GETFAGGEAGMAVPETVCTP-RAVGISVDVNVYEPHLLAGTMAHMIGHNIGMGHDDGREECFCRD 428
            |:.......|::.|..:|.| .:..|..|: :.:.:::|..|||.:|||:||.||:  ..|.|..
Human   293 GKWLYSHVQGISYPGGMCLPYYSTSIIKDL-LPDTNIIANRMAHQLGHNLGMQHDE--FPCTCPS 354

  Fly   429 WHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRTGHGLCLLNKPNEIELR--RNCGNKVVEEDE 491
            .. |:|.    ...::...|||:||:..|...|:.....|:||.|......  :.||||.::|.|
Human   355 GK-CVMD----SDGSIPALKFSKCSQNQYHQYLKDYKPTCMLNIPFPYNFHDFQFCGNKKLDEGE 414

  Fly   492 ECDCGTFEECALDQCCDGITCKLKSEAQCASGACCDQCRLRPKDYICRDSNNECDLPEYCDGEIG 556
            |||||..:||. :.|||..||.||....||.|.||:.|:::....|||.:.:|||.||.|.|...
Human   415 ECDCGPAQECT-NPCCDAHTCVLKPGFTCAEGECCESCQIKKAGSICRPAKDECDFPEMCTGHSP 478

  Fly   557 QCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSLQCEAIWGYGGSAADRQCYEQFNSKGSINGH 621
            .||.|.|:.||.||..|:    ||||.|.|||...||..::......:...|| :.|:||:..|:
Human   479 ACPKDQFRVNGFPCKNSE----GYCFMGKCPTREDQCSELFDDEAIESHDICY-KMNTKGNKFGY 538

  Fly   622 CGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDGIDQLYSRTIISIKGQEFECKATSGQVGSNS 686
            | ::....::.||.::|:||.:.|..||...:. |.|:.|...... |....:||.......|.
Human   539 C-KNKENRFLPCEEKDVRCGKIYCTGGELSSLL-GEDKTYHLKDPQ-KNATVKCKTIFLYHDST- 599

  Fly   687 YPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTKCPANSQGLECSEHGVCTNTNRCFCDMGWGG 751
              :.|||..||.||:.::|.|..|:::......|.||:     :|:|:.|..:..:|.|:.|
Human   600 --DIGLVASGTKCGEGMVCNNGECLNMEKVYISTNCPS-----QCNENPVDGHGLQCHCEEG--- 654

  Fly   752 NDCSSVVLLTTALPTEALPTPENTIKMEKKETPYGTSDQNRISTLTMVIILTVIVKCVFISFATL 816
                                          :.|....:...::.:|:::::.|:| .|.|....|
Human   655 ------------------------------QAPVACEETLHVTNITILVVVLVLV-IVGIGVLIL 688

  Fly   817 AVCYRRKTTTLK--YDPP----------------------------YSKKPIAKSYGGAATAPN 850
            .|.| ||...||  ..||                            :..||.:|...|.|. ||
Human   689 LVRY-RKCIKLKQVQSPPTETLGVENKGYFGDEQQIRTEPILPEIHFLNKPASKDSRGIAD-PN 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	104..214	CDD:460254	25/120 (21%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	54/202 (27%)
		Disintegrin	488..561	CDD:459709	34/72 (47%)
		ACR	566..713	CDD:214743	47/146 (32%)
ADAM7	NP_003808.2	Pep_M12B_propep	28..153	CDD:460254	30/138 (22%)
		Reprolysin	199..394	CDD:426256	56/204 (27%)
		DISIN	411..485	CDD:214490	35/74 (47%)
		ACR	488..624	CDD:214743	47/146 (32%)