DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mmd and ADAM9

DIOPT Version :9

Sequence 1:	NP_001285311.1	Gene:	mmd / 32561	FlyBaseID:	FBgn0259110	Length:	1484	Species:	Drosophila melanogaster
Sequence 2:	XP_016869431.1	Gene:	ADAM9 / 8754	HGNCID:	216	Length:	821	Species:	Homo sapiens

Alignment Length:	890	Identity:	272/890 - (30%)
Similarity:	382/890 - (42%)	Gaps:	201/890 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GEVERL-LKEYRQNQELVRRIGGHYYQIIYPVQLRHHEKMGISTREVSLPKPGQRPRPHDDSGFN 104
            |||:.. ...::|...|      ..|:||.|.:|         |||     ..:.|||:.
Human    26 GEVKHTNCSSFQQTSHL------SSYEIITPWRL---------TRE-----RREAPRPYS----- 65

  Fly   105 RGRTKKHFHRTSLLIKAFNHKFRLDLELNSQLLSPNIQQKHYHVGGYLVDGNRHDIEHCYYHGTV 169
                    .:.|.:|:|...:..:.||.|..||..:.....|:..|.|:..:.:...||:|.|.|
Human    66 --------KQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYV 122

  Fly   170 KDYPGASAAFHTCNGVSGVIHIGNETFVIHPFYGGDLSKHPHVIFEARTKANKGCANSGNLDSWR 234
            :....:|.|...|.|:.|::|:.|.::.|.|....  |...|:|:              .:|.
Human   123 EGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNS--SHFEHIIY--------------RMDD-- 169

  Fly   235 LSRRTKHLSAGVAGVVEEILQAGVG-----------------------RNKRDVREATKYIETAI 276
                          |.:|.|:.||.                       |.:|.|...|:|:|..|
Human   170 --------------VYKEPLKCGVSNKDIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFI 220

  Fly   277 IVDKAMFDKRNGSTRAEVIHDAIQVANIADLYFRTLNTRVSVVYIETW--GKNQAVIDGSKDISK 339
            :|||..:|.. |..:..|..:.|.:||..|..:..||.|:.:|.:|.|  |....::.|:.|:
Human   221 VVDKERYDMM-GRNQTAVREEMILLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDV-- 282

  Fly   340 AISNFNDYTSRNLFQIER---DTTQLLTGETFAGGEAGMAVPETVCTPRAVGISVDVNVY---EP 398
             :.||..:  |..|.|.|   |:.||:..:.| ||.||||...|||:....|   .:||:   ..
Human   283 -LGNFVQW--REKFLITRRRHDSAQLVLKKGF-GGTAGMAFVGTVCSRSHAG---GINVFGQITV 340

  Fly   399 HLLAGTMAHMIGHNIGMGHDDGREECFCRDWHGCIMAQSIVGQENVQPYKFSECSKKDYIDALRT 463
            ...|..:||.:|||:||.||||| :|.| ....|||.....|..|     ||.||.:|:......
Human   341 ETFASIVAHELGHNLGMNHDDGR-DCSC-GAKSCIMNSGASGSRN-----FSSCSAEDFEKLTLN 398

  Fly   464 GHGLCLLN--KPNEIELRRNCGNKVVEEDEECDCGTFEECALDQCCDGITCKLKSEAQCASGACC 526
            ..|.||||  ||:|.....:||||:|:..|||||||.:||.||.||:|.||||||.|:||.|.||
Human   399 KGGNCLLNIPKPDEAYSAPSCGNKLVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCC 463

  Fly   527 DQCRLRPKDYICRDSNNECDLPEYCDGEIGQCPSDVFKKNGSPCGLSKTGISGYCFQGYCPTLSL 591
            ..||..|...:||...:|||:||||:|....|..|||.:||.||..:|    .||:.|.|.....
Human   464 KDCRFLPGGTLCRGKTSECDVPEYCNGSSQFCQPDVFIQNGYPCQNNK----AYCYNGMCQYYDA 524

  Fly   592 QCEAIWGYGGSAADRQCYEQFNSKGSINGHCGRDANEHYIKCEPENVQCGTLQCKDGERQPVNDG 656
            ||:.|:|....||.:.|:.:.||||...|:||...|| |.||...|..||.|||::.:..||...
Human   525 QCQVIFGSKAKAAPKDCFIEVNSKGDRFGNCGFSGNE-YKKCATGNALCGKLQCENVQEIPVFGI 588

  Fly   657 IDQLYSRTIISIKGQEFECKATSGQVGSNSYPEHGLVKDGTPCGDNLICLNQTCVSLFPHVDQTK 721
            :.     .||....:..:|.....|:||: .|:.|:|.:||.||...||.|..||.  ..|....
Human   589 VP-----AIIQTPSRGTKCWGVDFQLGSD-VPDPGMVNEGTKCGAGKICRNFQCVD--ASVLNYD 645

  Fly   722 CPANSQGLECSEHGVCTNTNRCFCDMGWGGNDCSSVVLLTTALPTEALPTPENTIKMEKKETP-Y 785
            |....   :|..||||.:...|.|:.||...:|                           ||. |
Human   646 CDVQK---KCHGHGVCNSNKNCHCENGWAPPNC---------------------------ETKGY 680

  Fly   786 GTS-----DQNRIST------LTMVIILTVIVKC---VFISFATLAVCYRRKTTTLKYDP----- 831
            |.|     ..|.::|      |....::..::.|   :||....|...|.||..:..|:.
Human   681 GGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKRDQLWRSYFRKKRSQTYESDGKNQ 745

  Fly   832 --PYSKKPIAKSYGGAATAPNHHS----VEEVSLDGSSKLVYANQ 870
              | |::|        .:.|.|.|    ..||.       :|||:
Human   746 ANP-SRQP--------GSVPRHVSPVTPPREVP-------IYANR 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mmd	NP_001285311.1	Pep_M12B_propep	106..213	CDD:279848	27/106 (25%)
		Reprolysin	270..473	CDD:279729	74/212 (35%)
		ZnMc_adamalysin_II_like	270..471	CDD:239797	72/208 (35%)
		Disintegrin	488..562	CDD:278623	40/73 (55%)
		ACR	566..713	CDD:214743	54/146 (37%)
ADAM9	XP_016869431.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5934
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.870